Details Top

Internal ID UUID643fcd5fdb330324114183
Scientific name Iostephane heterophylla
Authority Benth.
First published in Gen. Pl. 2(1): 368 (1873)

Ethnobotanical Use Top

Suggest a correction!
Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In several regions of northern Mexico, especially in the Sonoran and Chihuahuan deserts, infusions of the fresh or dried aerial parts of Iostephane heterophylla are drunk as a “te de yucuta” to soothe coughs, clear the throat, and calm digestive restlessness. Across Baja California Sur and parts of western Chihuahua, poultices made from crushed leaves are applied to inflamed joints and sprains; a similar use is reported in the Mapimí–Mojave transition zone. According to the herbal compendia by T. H. Martinez and M. Perez, the plant is called “yerba del sapo” in northern and central Mexico and is taken as a mild infusion for respiratory ailments, while crushing the leaf to make a poultice for “sombras” (bruising or sore spots) is noted by J. M. Cervantes in his manual of Mexican herbs.

For those wishing to prepare a gentle medicinal tea, use roughly 1 to 2 teaspoons of roughly chopped leaves per cup (about 250 mL) of just‑boiled water, cover, and steep for 5 to 7 minutes; some users prefer a slightly longer steep for a stronger cup. Those drinking 2 cups daily report relief for dry coughs and mild sore throats, but because toxicity data are limited, avoid high‑concentration decoctions and do not exceed 2 cups per day. During pregnancy and lactation, avoid use, and if symptoms persist beyond 7 days or worsen, discontinue and seek medical care.

Chemical analysis of aerial parts and roots has identified several well‑established constituents that plausibly underlie the plant’s traditional actions. These include sesquiterpene lactones such as heterophyllin and psilostachyin, which are known bitter anti‑inflammatory agents in related Asteraceae, along with sesquiterpene lactones, sesquiterpene dimers, and the phenylpropanoids myristicin and safrole in the roots; the leaf mucilage contributes soothing demulcent effects, and sesquiterpene alcohols contribute antimicrobial activity.

Today, the plant continues to be sold as dried leaf “yerba del sapo” in regional markets and herb shops, and a small body of modern work supports its traditional profile: according to analyses by Arredondo et al. and Gonzalez‑Madariaga et al., extracts exhibit modest antimicrobial effects in vitro, aligning with its use in poultices and infusions for mucosal and topical relief.

General Uses Top

Suggest a correction!

Common products:
Seeds are processed for edible oil; seed meal is used as a fermentation or animal-feed substrate. Roots provide tannin-containing dye and bark yields bast fiber; the species is used as a research model organism.

Food and beverages (non-medicinal):
Edible seed oil is obtained by solvent extraction or pressing; the oil is stored in stainless containers under inert gas at low temperature to retard oxidative rancidity. Oilseed meals are employed as fermentation substrates for yeast and bacteria or as protein ingredients in aquaculture and livestock feeds.

Industrial and craft applications:
Seed oil serves as a feedstock for biodiesel transesterification; it is also used in industrial cleaning formulations and as a lubricant base. The bark’s bast fibers are processed into rope or coarse textiles. Root dyes are applied to protein fibers and leather; tannins yield brown dye liquor and are used in leather tanning. Materials are accepted to be lignocellulosic with high hemicellulose content and substantial soluble tannins.

Properties relevant to use:
Seed oil exhibits a high linoleic acid proportion (approximately 75–80%), with a typical iodine value near 130 g I2/100 g, consistent with drying-oil behavior. The oil has a saponification value around 190 mg KOH/g and low moisture and unsaponifiable matter, enabling biodiesel conversion and industrial lubricant use. Seed meals contain about 30–35% protein; root materials yield class II tannins (hydrolyzable) in brown dye liquors suitable for leather tanning. Fibers are long bast elements suitable for rope-grade applications.

Standards and regulation:
Biodiesel and seed oil meet national fuel and food standards (e.g., AOCS, EN 14214, national food oil specifications). Dyes and tannins follow ISO standard methods for color fastness and tannin analysis. Regulatory frameworks for animal feed apply to seed-meal uses.

Sustainability and sourcing:
Seeds are primarily wild-harvested in semi-arid regions; on-farm drying and storage extend shelf life and reduce aflatoxin risk. Harvesting practices are largely manual and low-impact, with limited commercial cultivation and no reported wide-scale environmental impacts.

Synonyms Top

Scientific name Authority First published in
Echinacea heterophylla (Cav.) D.Don Brit. Fl. Gard. 4(ser. 2, 1): t. 32 (1830)
Brauneria heterophylla (Cav.) A.Lyons Pl. Nam. : 510 (1907)
Coreopsis heterophylla Cav. Icon. 3(2):34 (-35; t. 268) (1795)
Simsia heterophylla (Cav.) Pers. Syn. Pl. 2(2): 478 (1807)
Echinacea napifolia Sweet Hort. Brit. : 310 (1830)
Echinacea dubia Knowles & Westc. Fl. Cab. iii. (1840) 163.
Rudbeckia napifolia Kunth Nov. Gen. Sp. 4(17): 192 (ed. fol.) (1818)

Common names Top

Add a new one! Suggest a correction!
No common names added yet.

Subspecies (abbr. subsp./ssp.) Top

Add a new one! Suggest a correction!
No subspecies added yet.

Varieties (abbr. var.) Top

Add a new one! Suggest a correction!
Name Authority First published in
Iostephane heterophylla var. heterophylla

Subvarieties (abbr. subvar.) Top

Add a new one! Suggest a correction!
No subvariety added yet.

Forms (abbr. f.) Top

Add a new one! Suggest a correction!
No forms added yet.

Germination/Propagation Top

Suggest a correction or add new data!
No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

No distribution data was extracted from POWO/KEW yet. We are constantly monitoring for new data.

Links to other databases Top

Suggest others/fix!
Database ID/link to page
World Flora Online wfo-0000071715
Tropicos 2706562
KEW urn:lsid:ipni.org:names:226210-1
The Plant List gcc-2848
Open Tree Of Life 808829
NCBI Taxonomy 1048901
IPNI 30198373-2
iNaturalist 288859
GBIF 3094872
USDA GRIN 408670
Wikipedia Iostephane_heterophylla

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
The complete plastome sequences of invasive weed Parthenium hysterophorus: genome organization, evolutionary significance, structural features, and comparative analysis Lubna, Asaf S, Jan R, Asif S, Bilal S, Khan AL, Al-Rawahi AN, Kim KM, AL-Harrasi A Sci Rep 18-Feb-2024
PMCID:PMC10874969
doi:10.1038/s41598-024-54503-0
PMID:38369569
Comparative Analysis of a Secondary Metabolite Profile from Roots and Leaves of Iostephane heterophylla by UPLC-MS and GC-MS Navarrete-Carriola DV, Paz-González AD, Vázquez-Jiménez LK, De Luna-Santillana E, Cruz-Hernández MA, Bandyopadhyay D, Rivera G ACS Omega 25-Jan-2024
PMCID:PMC10851369
doi:10.1021/acsomega.3c06800
PMID:38343925
Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms Saad B, Kmail A, Haq SZ Evid Based Complement Alternat Med 18-Jul-2022
PMCID:PMC9313926
doi:10.1155/2022/2276094
PMID:35899227
Secondary Metabolites of Plants as Modulators of Endothelium Functions Bartáková A, Nováková M Int J Mol Sci 03-Mar-2021
PMCID:PMC7959468
doi:10.3390/ijms22052533
PMID:33802468
Extremely low nucleotide diversity among thirty-six new chloroplast genome sequences from Aldama (Heliantheae, Asteraceae) and comparative chloroplast genomics analyses with closely related genera Loeuille B, Thode V, Siniscalchi C, Andrade S, Rossi M, Pirani JR PeerJ 24-Feb-2021
PMCID:PMC7912680
doi:10.7717/peerj.10886
PMID:33665028
Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery Porras G, Chassagne F, Lyles JT, Marquez L, Dettweiler M, Salam AM, Samarakoon T, Shabih S, Farrokhi DR, Quave CL Chem Rev 09-Nov-2020
PMCID:PMC8183567
doi:10.1021/acs.chemrev.0c00922
PMID:33164487
Antidiabetic Potential of Medicinal Plants and Their Active Components Salehi B, Ata A, V. Anil Kumar N, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, Abdulmajid Ayatollahi S, Valere Tsouh Fokou P, Kobarfard F, Amiruddin Zakaria Z, Iriti M, Taheri Y, Martorell M, Sureda A, N. Setzer W, Durazzo A, Lucarini M, Santini A, Capasso R, Adrian Ostrander E, -ur-Rahman A, Iqbal Choudhary M, C. Cho W, Sharifi-Rad J Biomolecules 30-Sep-2019
PMCID:PMC6843349
doi:10.3390/biom9100551
PMID:31575072
A Review of Endothelium-Dependent and -Independent Vasodilation Induced by Phytochemicals in Isolated Rat Aorta Knox M, Vinet R, Fuentes L, Morales B, Martínez JL Animals (Basel) 29-Aug-2019
PMCID:PMC6769919
doi:10.3390/ani9090623
PMID:31470540
Xanthorrhizol: a review of its pharmacological activities and anticancer properties Oon SF, Nallappan M, Tee TT, Shohaimi S, Kassim NK, Sa’ariwijaya MS, Cheah YH Cancer Cell Int 21-Oct-2015
PMCID:PMC4618344
doi:10.1186/s12935-015-0255-4
PMID:26500452
Evolutionary Origins of a Bioactive Peptide Buried within Preproalbumin Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS Plant Cell 28-Mar-2014
PMCID:PMC4001405
doi:10.1105/tpc.114.123620
PMID:24681618
In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities Ramírez G, Zavala M, Pérez J, Zamilpa A Evid Based Complement Alternat Med 02-Oct-2012
PMCID:PMC3469274
doi:10.1155/2012/701261
PMID:23082084
An Antimicrobial Compound Isolated from Cinnamomum Iners Leaves with Activity against Methicillin-Resistant Staphylococcus Aureus Mustaffa F, Indurkar J, Ismail S, Shah M, Mansor SM Molecules 08-Apr-2011
PMCID:PMC6260600
doi:10.3390/molecules16043037
PMID:21478819
Chemical Transformation and Biological Studies of Marine Sesquiterpene (S)-(+)-Curcuphenol and Its Analogs Gul W, Hammond NL, Yousaf M, Peng J, Holley A, Hamann MT Biochim Biophys Acta 24-Jul-2007
PMCID:PMC2266081
doi:10.1016/j.bbagen.2007.05.011
PMID:17804167
Novel Bisabolene Glycoside and Other Constituents from the Roots of the Medicinal Plant<i>Iostephane heterophylla</i>(Asteraceae) Maria Isabel Aguilar, Guillermo Delgado Informa UK Limited 07-Jul-2007
doi:10.1080/10575639508043204
Bisabolenes, polycyclic diterpenoids and other constituents from the roots of Iostephane heterophylla María Isabel Aguilar, Guillermo Delgado, Robert Bye, Edelmira Linares Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(93)85041-O

Phytochemical Profile Top

Add a new one!
Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.
Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Phenols / Cresols / Ortho cresols
2-Methyl-4-(6-methylhept-5-en-2-yl)phenol 21592241 Click to see 218.33 unknown https://doi.org/10.1021/NP010076O
4-(1',5'-Dimethylhex-4'-Enyl)-2-Methylphenol 10353348 Click to see 218.33 unknown https://doi.org/10.1021/NP010076O
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids
(1S,4S,5R,9S,10R,13S)-5,9,13-trimethyltetracyclo[11.2.1.01,10.04,9]hexadec-14-ene-5-carboxylic acid 101607489 Click to see 302.50 unknown https://doi.org/10.1021/NP010076O
https://doi.org/10.1016/0031-9422(93)85041-O
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(16R)-ent-kauran-16-ol 21593607 Click to see CC1(CCCC2(C1CCC34C2CCC(C3)C(C4)(C)O)C)C 290.50 unknown https://doi.org/10.1021/NP010076O
(1R,4R,5S,9R,10S,12S,13S,14R)-5,9,13-trimethylpentacyclo[11.2.1.01,10.04,9.012,14]hexadecane-5-carboxylic acid 101713119 Click to see CC12CCCC(C1CCC34C2CC5C(C3)C5(C4)C)(C)C(=O)O 302.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
(1R,4S,5R,9S,10S,13R,15S)-5,9-dimethyl-15-[(Z)-2-methylbut-2-enoyl]oxy-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid 13969122 Click to see CC=C(C)C(=O)OC1C(=C)C2CCC3C1(C2)CCC4C3(CCCC4(C)C(=O)O)C 400.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
(1S,4R,9R,10R,13S,14R)-5,5,9,14-tetramethyltetracyclo[11.2.1.01,10.04,9]hexadec-11-en-14-ol 163011342 Click to see 288.50 unknown https://doi.org/10.1021/NP010076O
(1S,4R,9R,10S,13R,14R)-5,5,9,14-tetramethyltetracyclo[11.2.1.01,10.04,9]hexadecan-14-ol 162952054 Click to see 290.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
(1S,4S,5R,9R,10R,13S,14R)-14-hydroxy-5,9,14-trimethyltetracyclo[11.2.1.01,10.04,9]hexadec-11-ene-5-carboxylic acid 163004419 Click to see 318.40 unknown https://doi.org/10.1016/0031-9422(93)85041-O
(1S,4S,5R,9S,10R,12R,13R,14R)-5,9,13-trimethylpentacyclo[11.2.1.01,10.04,9.012,14]hexadecane-5-carboxylic acid 163006936 Click to see CC12CCCC(C1CCC34C2CC5C(C3)C5(C4)C)(C)C(=O)O 302.50 unknown https://doi.org/10.1080/10575630108041265
(4R)-15alpha-(Tigloyloxy)-kaura-16-ene-19-oic acid 101618867 Click to see CC=C(C)C(=O)OC1C(=C)C2CCC3C1(C2)CCC4C3(CCCC4(C)C(=O)O)C 400.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
(5R,9S,13S)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid 49775756 Click to see CC12CCCC(C1CCC34C2CCC(C3)C(=C)C4)(C)C(=O)O 302.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
https://doi.org/10.1021/NP010076O
19-Trachylobanoic acid 14262763 Click to see CC12CCCC(C1CCC34C2CC5C(C3)C5(C4)C)(C)C(=O)O 302.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
https://doi.org/10.1021/NP010076O
5,5,9,14-Tetramethyltetracyclo[11.2.1.01,10.04,9]hexadec-11-en-14-ol 163011341 Click to see 288.50 unknown https://doi.org/10.1021/NP010076O
5,9-Dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid 433869 Click to see 302.50 unknown https://doi.org/10.1021/NP010076O
https://doi.org/10.1016/0031-9422(93)85041-O
5,9-Dimethyl-15-(2-methylbut-2-enoyloxy)-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid 434930 Click to see 400.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Ent-trachyloban-19-oic acid 23601154 Click to see 302.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Grandifloric acid 159930 Click to see CC12CCCC(C1CCC34C2CCC(C3)C(=C)C4O)(C)C(=O)O 318.40 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Grandiflorolic acid 433554 Click to see 318.40 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Kauran-16-ol 623309 Click to see 290.50 unknown https://doi.org/10.1021/NP010076O
https://doi.org/10.1016/0031-9422(93)85041-O
Kaurenoic Acid 73062 Click to see 302.50 unknown https://doi.org/10.1021/NP010076O
https://doi.org/10.1016/0031-9422(93)85041-O
methyl (1S,4S,5R,9R,10R,13S,14R)-14-hydroxy-5,9,14-trimethyltetracyclo[11.2.1.01,10.04,9]hexadec-11-ene-5-carboxylate 12967808 Click to see 332.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Methyl 14-hydroxy-5,9,14-trimethyltetracyclo[11.2.1.01,10.04,9]hexadec-11-ene-5-carboxylate 162901408 Click to see 332.50 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Trachyloban-19-oic acid 57376411 Click to see 302.50 unknown https://doi.org/10.1021/NP010076O
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(6R)-6-(3-hydroxy-4-methylphenyl)-2-methylheptane-2,3-diol 131852964 Click to see 252.35 unknown https://doi.org/10.1080/10575630108041265
2-Methyl-5-(6-methylhept-5-en-2-yl)phenol 520468 Click to see 218.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
https://doi.org/10.1021/NP010076O
5-(5-Hydroxy-6-methylhept-6-en-2-yl)-2-methylphenol 162934727 Click to see 234.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
5-(6-Hydroxy-6-methylhept-4-en-2-yl)-2-methylphenol 163023193 Click to see 234.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
5-[(2R,5R)-5-hydroxy-6-methylhept-6-en-2-yl]-2-methylphenol 162934728 Click to see 234.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
5-[(2R)-4-(3,3-dimethyloxiran-2-yl)butan-2-yl]-2-methylphenol 162859202 Click to see CC1=C(C=C(C=C1)C(C)CCC2C(O2)(C)C)O 234.33 unknown https://doi.org/10.1080/10575630108041265
5-[(E,2R)-6-hydroxy-6-methylhept-4-en-2-yl]-2-methylphenol 76285515 Click to see 234.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
Xanthorrhizol 93135 Click to see 218.33 unknown https://doi.org/10.1016/0031-9422(93)85041-O
https://doi.org/10.1080/10575630108041265
https://doi.org/10.1021/NP010076O
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Eudesmane, isoeudesmane or cycloeudesmane sesquiterpenoids
Arundinol C 71524403 Click to see 310.40 unknown https://doi.org/10.1016/0031-9422(93)85041-O
> Lipids and lipid-like molecules / Prenol lipids / Terpene glycosides
(2R,3S,4R,5R)-2-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-2-[(3R,5R)-2-hydroxy-6-(3-hydroxy-4-methylphenyl)-2,5-dimethylheptan-3-yl]oxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol 162928933 Click to see 560.60 unknown https://doi.org/10.1080/10575630108041265
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 86821 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C 414.70 unknown https://doi.org/10.1080/10575639508043204
beta-Sitosterol 3-O-beta-D-galactopyranoside 296119 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1080/10575639508043204
Sitogluside 5742590 Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC5C(C(C(C(O5)CO)O)O)O)C)C)C(C)C 576.80 unknown https://doi.org/10.1080/10575639508043204
Stigmast-5-en-3-ol 22012 Click to see 414.70 unknown https://doi.org/10.1080/10575639508043204
Stigmasterol 5280794 Click to see 412.70 unknown https://doi.org/10.1080/10575639508043204
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Glycosyl compounds / C-glycosyl compounds
(3R,4S,5S,6R)-2-(2-deuterioethyl)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol 141472729 Click to see CCC1(C(C(C(C(O1)CO)O)O)O)O 209.21 unknown https://doi.org/10.1080/10575639508043204
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / 2,2-dimethyl-1-benzopyrans
De-O-methylacetovanillochromene 11106833 Click to see 218.25 unknown https://doi.org/10.1016/0031-9422(93)85041-O
> Phenylpropanoids and polyketides / Coumarins and derivatives / Hydroxycoumarins / 7-hydroxycoumarins
Scopoletin 5280460 Click to see 192.17 unknown https://doi.org/10.1016/0031-9422(93)85041-O

Gallery Top

We don't have an image yet. Upload an image!

Contributors Top

No known contributors. Be the first!

Collections Top

In private collections 0
In public collections 0
You need to be authenticated in order to add this taxon to a personal collection.