Lorazepam

Details

• Internal ID: 270a5df9-a182-4cd6-8298-18bd2a3af198
• Taxonomy: Organoheterocyclic compounds > Benzodiazepines > 1,4-benzodiazepines
• IUPAC Name: 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
• SMILES (Canonical): C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
• SMILES (Isomeric): C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
• InChI: InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
• InChI Key: DIWRORZWFLOCLC-UHFFFAOYSA-N
• Popularity: 16,458 references in papers

Physical and Chemical Properties

• Molecular Formula: C₁₅H₁₀Cl₂N₂O₂
• Molecular Weight: 321.20 g/mol
• Exact Mass: 320.0119330 g/mol
• Topological Polar Surface Area (TPSA): 61.70 Ų
• XlogP: 2.40

Synonyms

• Ativan
• 846-49-1
• o-Chloroxazepam
• o-Chlorooxazepam
• Temesta
• Loraz
• Bonatranquan
• Anxiedin
• Lorabenz
• Sedatival
• Orfidal
• Punktyl
• Quait
• Tavor
• Delormetazepam
• Almazine
• Aplacasse
• Aplacassee
• Azurogen
• Duralozam
• Efasedan
• Emotival
• Kalmalin
• Lorazene
• Lorazepam Intensol
• Lorsedal
• Novhepar
• Renaquil
• Rocosgen
• Sedizepan
• Tranqipam
• Anxira
• Anzepam
• Aripax
• Bonton
• Equitam
• Larpose
• Laubeel
• Lorapam
• Lorazep
• Lorazin
• Lorenin
• Loridem
• Lozepam
• Merlit
• Sidenar
• Silence
• Stapam
• Trapax
• Loram
• Lorat
• Lorax
• Wypax
• Upan
• Apo-Lorazepam
• Nervistop L
• Lorazepamum
• Nervistopl
• Norlormetazepam
• Novolorazem
• Emotion
• Lomesta
• Lorafen
• Lorazon
• Lorivan
• Vigiten
• Lopam
• Lorans
• Lorzem
• Lorazepam Fabra
• Lorazepam-Efeka
• Lorazepan Chobet
• Lorazepan Richet
• Wy-4036
• Max Pax
• Demethyllormetazepam
• Lorazepam Genericon
• Lorazepam Lannacher
• Wy 4036
• Lorazepam preservative free
• (+/-)-Lorazepam
• Lorazepam civ
• Lorazepamum [INN-Latin]
• 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
• NSC 289758
• EINECS 212-687-6
• UNII-O26FZP769L
• BRN 0759084
• Idalprem
• O26FZP769L
• DTXSID7023225
• LOREEV XR
• 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
• 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
• Sinestron
• NSC289758
• Donix
• Tolid
• CHEMBL580
• 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
• Lorazepam Medical
• Nu Loraz
• DTXCID303225
• Somagerol
• 5-25-02-00248 (Beilstein Handbook Reference)
• Lorazepam [USAN:USP:INN:BAN:JAN]
• NSC-289758
• NCGC00159439-02
• Lorsilan
• Securit
• Sedazin
• Lorazepamum (INN-Latin)
• Pro dorm
• LORAZEPAM (MART.)
• LORAZEPAM [MART.]
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
• LORAZEPAM (EP IMPURITY)
• LORAZEPAM [EP IMPURITY]
• LORAZEPAM CIV (USP-RS)
• LORAZEPAM CIV [USP-RS]
• LORAZEPAM (EP MONOGRAPH)
• LORAZEPAM [EP MONOGRAPH]
• LORAZEPAM (USP MONOGRAPH)
• LORAZEPAM [USP MONOGRAPH]
• Lorazepam (USAN:USP:INN:BAN:JAN)
• (+/-)-7-CHLORO-5-(O-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-2H-1,4-BENZODIAZEPIN-2-ONE
• 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-, (+/-)-
• Ativan (TN)
• Loracepam
• DEA No. 2885
• LORAZEPAM [INN]
• LORAZEPAM [JAN]
• LORAZEPAM [MI]
• LORAZEPAM [USAN]
• (.+/-.)-Lorazepam
• LORAZEPAM [VANDF]
• LORAZEPAM [WHO-DD]
• (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
• SCHEMBL26961
• MLS001424236
• DivK1c_000965
• Lorazepam (JP17/USP/INN)
• CHEBI:6539
• GTPL5884
• LORAZEPAM [ORANGE BOOK]
• HMS503A11
• KBio1_000965
• N05BA06
• NINDS_000965
• HMS2052H07
• HMS3394H07
• Lorazepam, 1mg/ml in Acetonitrile
• BCP13713
• Tox21_111669
• BDBM50292627
• Lorazepam 0.1 mg/ml in Acetonitrile
• Lorazepam 1.0 mg/ml in Acetonitrile
• AKOS015904303
• CCG-101170
• DB00186
• NC00420
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-
• IDI1_000965
• CAS-846-49-1
• SMR000058410
• WLN: T67 GMV JN IHJ CG IQ KR BG
• D00365
• A840886
• Q408265
• 7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one
• BRD-A11990600-001-01-8
• Lorazepam, British Pharmacopoeia (BP) Reference Standard
• Lorazepam, European Pharmacopoeia (EP) Reference Standard
• 2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
• 2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
• Lorazepam, United States Pharmacopeia (USP) Reference Standard
• O-Chloroxazepam; O-Chlorooxazepam; Almazine; WY 4036; WY-4036; WY4036
• (3RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one
• 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
• 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one
• 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one
• 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4-Benzodiazepin-2-one
• 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one
• 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one #
• 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one
• 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one
• Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard
• LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one
• (RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
• 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam)

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
No predicted properties yet!

Targets

Proven Targets:

No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL5619	P27695	DNA-(apurinic or apyrimidinic site) lyase	95.50%	91.11%
CHEMBL4026	P40763	Signal transducer and activator of transcription 3	93.81%	82.69%
CHEMBL3108638	O15164	Transcription intermediary factor 1-alpha	92.66%	95.56%
CHEMBL3524	P56524	Histone deacetylase 4	90.06%	92.97%
CHEMBL1907600	Q00535	Cyclin-dependent kinase 5/CDK5 activator 1	89.46%	93.03%
CHEMBL1293249	Q13887	Kruppel-like factor 5	88.39%	86.33%
CHEMBL2635	P51452	Dual specificity protein phosphatase 3	87.69%	94.00%
CHEMBL3401	O75469	Pregnane X receptor	87.37%	94.73%
CHEMBL1937	Q92769	Histone deacetylase 2	86.90%	94.75%
CHEMBL218	P21554	Cannabinoid CB1 receptor	85.83%	96.61%
CHEMBL2335	P42785	Lysosomal Pro-X carboxypeptidase	85.83%	100.00%
CHEMBL2820	P03951	Coagulation factor XI	83.55%	95.29%
CHEMBL2035	P08912	Muscarinic acetylcholine receptor M5	82.69%	94.62%
CHEMBL2581	P07339	Cathepsin D	82.59%	98.95%
CHEMBL4530	P00488	Coagulation factor XIII	80.18%	96.00%

Plants that contains it

• Triticum aestivum

Cross-Links

• PubChem: 3958
• LOTUS: LTS0115481
• wikiData: Q408265