Linoleoyl ethanolamide
| Internal ID | 02bbe16c-b09f-4ff4-b346-f6eb4d178f44 |
| Taxonomy | Organic nitrogen compounds > Organonitrogen compounds > Amines > Alkanolamines > 1,2-aminoalcohols > N-acylethanolamines |
| IUPAC Name | (9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide |
| SMILES (Canonical) | CCCCCC=CCC=CCCCCCCCC(=O)NCCO |
| SMILES (Isomeric) | CCCCC/C=C\C/C=C\CCCCCCCC(=O)NCCO |
| InChI | InChI=1S/C20H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h6-7,9-10,22H,2-5,8,11-19H2,1H3,(H,21,23)/b7-6-,10-9- |
| InChI Key | KQXDGUVSAAQARU-HZJYTTRNSA-N |
| Popularity | 59 references in papers |
| Molecular Formula | C20H37NO2 |
| Molecular Weight | 323.50 g/mol |
| Exact Mass | 323.282429423 g/mol |
| Topological Polar Surface Area (TPSA) | 49.30 Ų |
| XlogP | 5.60 |
| Atomic LogP (AlogP) | 4.91 |
| H-Bond Acceptor | 2 |
| H-Bond Donor | 2 |
| Rotatable Bonds | 16 |
| 68171-52-8 |
| Linoleamide MEA |
| Linoleylethanolamide |
| Linoleoylethanolamide |
| Linoleic ethanolamide |
| n-linoleoylethanolamine |
| (9Z,12Z)-N-(2-hydroxyethyl)octadeca-9,12-dienamide |
| Linoleoyl monoethanolamide |
| Linoleyl ethanolamide |
| N-(2-Hydroxyethyl)linoleamide |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9777 | 97.77% |
| Caco-2 | - | 0.5808 | 58.08% |
| Blood Brain Barrier | + | 0.8250 | 82.50% |
| Human oral bioavailability | - | 0.7286 | 72.86% |
| Subcellular localzation | Mitochondria | 0.4551 | 45.51% |
| OATP2B1 inhibitior | - | 0.8548 | 85.48% |
| OATP1B1 inhibitior | - | 0.3431 | 34.31% |
| OATP1B3 inhibitior | + | 0.9292 | 92.92% |
| MATE1 inhibitior | - | 0.9800 | 98.00% |
| OCT2 inhibitior | - | 0.9500 | 95.00% |
| BSEP inhibitior | - | 0.6095 | 60.95% |
| P-glycoprotein inhibitior | - | 0.7643 | 76.43% |
| P-glycoprotein substrate | - | 0.6696 | 66.96% |
| CYP3A4 substrate | - | 0.5647 | 56.47% |
| CYP2C9 substrate | - | 0.6108 | 61.08% |
| CYP2D6 substrate | - | 0.8517 | 85.17% |
| CYP3A4 inhibition | - | 0.8383 | 83.83% |
| CYP2C9 inhibition | - | 0.9071 | 90.71% |
| CYP2C19 inhibition | - | 0.9025 | 90.25% |
| CYP2D6 inhibition | - | 0.9231 | 92.31% |
| CYP1A2 inhibition | + | 0.9107 | 91.07% |
| CYP2C8 inhibition | - | 0.8417 | 84.17% |
| CYP inhibitory promiscuity | - | 0.9112 | 91.12% |
| UGT catelyzed | + | 0.8000 | 80.00% |
| Carcinogenicity (binary) | - | 0.7500 | 75.00% |
| Carcinogenicity (trinary) | Non-required | 0.5881 | 58.81% |
| Eye corrosion | - | 0.8106 | 81.06% |
| Eye irritation | - | 0.6700 | 67.00% |
| Skin irritation | - | 0.6866 | 68.66% |
| Skin corrosion | - | 0.9455 | 94.55% |
| Ames mutagenesis | - | 0.9400 | 94.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.4935 | 49.35% |
| Micronuclear | - | 0.7700 | 77.00% |
| Hepatotoxicity | - | 0.5355 | 53.55% |
| skin sensitisation | - | 0.9386 | 93.86% |
| Respiratory toxicity | - | 0.8333 | 83.33% |
| Reproductive toxicity | - | 0.5764 | 57.64% |
| Mitochondrial toxicity | - | 0.8750 | 87.50% |
| Nephrotoxicity | + | 0.4871 | 48.71% |
| Acute Oral Toxicity (c) | III | 0.5354 | 53.54% |
| Estrogen receptor binding | + | 0.7007 | 70.07% |
| Androgen receptor binding | - | 0.8230 | 82.30% |
| Thyroid receptor binding | + | 0.7086 | 70.86% |
| Glucocorticoid receptor binding | - | 0.7306 | 73.06% |
| Aromatase binding | - | 0.6247 | 62.47% |
| PPAR gamma | + | 0.7811 | 78.11% |
| Honey bee toxicity | - | 0.9880 | 98.80% |
| Biodegradation | + | 0.6000 | 60.00% |
| Crustacea aquatic toxicity | + | 0.7183 | 71.83% |
| Fish aquatic toxicity | - | 0.5000 | 50.00% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL4794 | Q8NER1 | Vanilloid receptor |
630 nM |
EC50 |
via Super-PRED
|
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL3060 | Q9Y345 | Glycine transporter 2 | 98.70% | 99.17% |
| CHEMBL230 | P35354 | Cyclooxygenase-2 | 98.26% | 89.63% |
| CHEMBL2581 | P07339 | Cathepsin D | 97.47% | 98.95% |
| CHEMBL3892 | Q99500 | Sphingosine 1-phosphate receptor Edg-3 | 94.74% | 97.29% |
| CHEMBL4769 | O95749 | Geranylgeranyl pyrophosphate synthetase | 93.49% | 92.08% |
| CHEMBL2664 | P23526 | Adenosylhomocysteinase | 91.42% | 86.67% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 90.63% | 96.09% |
| CHEMBL1781 | P11387 | DNA topoisomerase I | 86.38% | 97.00% |
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 86.10% | 91.11% |
| CHEMBL1293267 | Q9HC97 | G-protein coupled receptor 35 | 85.18% | 89.34% |
| CHEMBL2885 | P07451 | Carbonic anhydrase III | 84.62% | 87.45% |
| CHEMBL5701 | Q9H2K8 | Serine/threonine-protein kinase TAO3 | 84.20% | 96.67% |
| CHEMBL221 | P23219 | Cyclooxygenase-1 | 84.03% | 90.17% |
| CHEMBL2111367 | P27986 | PI3-kinase p110-alpha/p85-alpha | 83.82% | 94.33% |
| CHEMBL1907602 | P06493 | Cyclin-dependent kinase 1/cyclin B1 | 83.71% | 91.24% |
| CHEMBL3038477 | P67870 | Casein kinase II alpha/beta | 83.42% | 99.23% |
| CHEMBL5043 | Q6P179 | Endoplasmic reticulum aminopeptidase 2 | 82.50% | 91.81% |
| CHEMBL4793 | Q86TI2 | Dipeptidyl peptidase IX | 82.46% | 96.95% |
| CHEMBL2955 | O95136 | Sphingosine 1-phosphate receptor Edg-5 | 81.74% | 92.86% |
| CHEMBL4179 | P45984 | c-Jun N-terminal kinase 2 | 81.66% | 90.75% |
| CHEMBL1907591 | P30926 | Neuronal acetylcholine receptor; alpha4/beta4 | 81.60% | 100.00% |
| CHEMBL5261 | Q7L7X3 | Serine/threonine-protein kinase TAO1 | 81.17% | 89.33% |
| CHEMBL2265 | P23141 | Acyl coenzyme A:cholesterol acyltransferase | 80.10% | 85.94% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| Ricinus communis |
| PubChem | 5283446 |
| LOTUS | LTS0115325 |
| wikiData | Q27132980 |