Cannabigerol
| Internal ID | 9629ad8f-df5c-49ff-b213-3de416ae01dc |
| Taxonomy | Lipids and lipid-like molecules > Prenol lipids > Monoterpenoids > Aromatic monoterpenoids |
| IUPAC Name | 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol |
| SMILES (Canonical) | CCCCCC1=CC(=C(C(=C1)O)CC=C(C)CCC=C(C)C)O |
| SMILES (Isomeric) | CCCCCC1=CC(=C(C(=C1)O)C/C=C(\C)/CCC=C(C)C)O |
| InChI | InChI=1S/C21H32O2/c1-5-6-7-11-18-14-20(22)19(21(23)15-18)13-12-17(4)10-8-9-16(2)3/h9,12,14-15,22-23H,5-8,10-11,13H2,1-4H3/b17-12+ |
| InChI Key | QXACEHWTBCFNSA-SFQUDFHCSA-N |
| Popularity | 141 references in papers |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.50 g/mol |
| Exact Mass | 316.240230259 g/mol |
| Topological Polar Surface Area (TPSA) | 40.50 Ų |
| XlogP | 7.40 |
| Atomic LogP (AlogP) | 6.07 |
| H-Bond Acceptor | 2 |
| H-Bond Donor | 2 |
| Rotatable Bonds | 9 |
| 25654-31-3 |
| Cannabigerol (CBG) |
| 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol |
| CHEMBL497318 |
| CBG |
| UNII-J1K406072N |
| CHEBI:69477 |
| 1,3-Benzenediol, 2-(3,7-dimethyl-2,6-octadienyl)-5-pentyl-, (E)- |
| J1K406072N |
| 2808-33-5 |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9949 | 99.49% |
| Caco-2 | + | 0.9238 | 92.38% |
| Blood Brain Barrier | + | 0.5750 | 57.50% |
| Human oral bioavailability | - | 0.6571 | 65.71% |
| Subcellular localzation | Mitochondria | 0.7468 | 74.68% |
| OATP2B1 inhibitior | - | 0.7101 | 71.01% |
| OATP1B1 inhibitior | + | 0.7986 | 79.86% |
| OATP1B3 inhibitior | + | 0.9393 | 93.93% |
| MATE1 inhibitior | - | 1.0000 | 100.00% |
| OCT2 inhibitior | - | 0.6750 | 67.50% |
| BSEP inhibitior | + | 0.7664 | 76.64% |
| P-glycoprotein inhibitior | - | 0.4918 | 49.18% |
| P-glycoprotein substrate | - | 0.7736 | 77.36% |
| CYP3A4 substrate | - | 0.5078 | 50.78% |
| CYP2C9 substrate | - | 0.7887 | 78.87% |
| CYP2D6 substrate | + | 0.3876 | 38.76% |
| CYP3A4 inhibition | + | 0.8050 | 80.50% |
| CYP2C9 inhibition | + | 0.6027 | 60.27% |
| CYP2C19 inhibition | + | 0.6829 | 68.29% |
| CYP2D6 inhibition | - | 0.7048 | 70.48% |
| CYP1A2 inhibition | + | 0.7980 | 79.80% |
| CYP2C8 inhibition | - | 0.5759 | 57.59% |
| CYP inhibitory promiscuity | + | 0.8924 | 89.24% |
| UGT catelyzed | + | 0.7000 | 70.00% |
| Carcinogenicity (binary) | - | 0.7811 | 78.11% |
| Carcinogenicity (trinary) | Non-required | 0.6930 | 69.30% |
| Eye corrosion | - | 0.9337 | 93.37% |
| Eye irritation | + | 0.6191 | 61.91% |
| Skin irritation | - | 0.6251 | 62.51% |
| Skin corrosion | - | 0.7548 | 75.48% |
| Ames mutagenesis | - | 0.7200 | 72.00% |
| Human Ether-a-go-go-Related Gene inhibition | + | 0.8028 | 80.28% |
| Micronuclear | - | 0.9500 | 95.00% |
| Hepatotoxicity | - | 0.7625 | 76.25% |
| skin sensitisation | + | 0.7100 | 71.00% |
| Respiratory toxicity | - | 0.6000 | 60.00% |
| Reproductive toxicity | - | 0.5222 | 52.22% |
| Mitochondrial toxicity | - | 0.6000 | 60.00% |
| Nephrotoxicity | - | 0.7223 | 72.23% |
| Acute Oral Toxicity (c) | III | 0.6062 | 60.62% |
| Estrogen receptor binding | + | 0.7068 | 70.68% |
| Androgen receptor binding | + | 0.7091 | 70.91% |
| Thyroid receptor binding | + | 0.7203 | 72.03% |
| Glucocorticoid receptor binding | + | 0.5923 | 59.23% |
| Aromatase binding | + | 0.6735 | 67.35% |
| PPAR gamma | + | 0.9173 | 91.73% |
| Honey bee toxicity | - | 0.9457 | 94.57% |
| Biodegradation | - | 0.7750 | 77.50% |
| Crustacea aquatic toxicity | + | 0.7442 | 74.42% |
| Fish aquatic toxicity | + | 1.0000 | 100.00% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL218 | P21554 | Cannabinoid CB1 receptor |
3310 nM 760 nM |
IC50 Ki |
PMID: 21902175
via Super-PRED |
| CHEMBL253 | P34972 | Cannabinoid CB2 receptor |
3460 nM 153 nM |
IC50 Ki |
PMID: 21902175
via Super-PRED |
| CHEMBL4794 | Q8NER1 | Vanilloid receptor |
2600 nM |
IC50 |
PMID: 21902175
|
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL4769 | O95749 | Geranylgeranyl pyrophosphate synthetase | 99.71% | 92.08% |
| CHEMBL2581 | P07339 | Cathepsin D | 97.83% | 98.95% |
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 96.48% | 91.11% |
| CHEMBL3401 | O75469 | Pregnane X receptor | 94.33% | 94.73% |
| CHEMBL3060 | Q9Y345 | Glycine transporter 2 | 93.14% | 99.17% |
| CHEMBL1951 | P21397 | Monoamine oxidase A | 92.93% | 91.49% |
| CHEMBL215 | P09917 | Arachidonate 5-lipoxygenase | 89.61% | 92.68% |
| CHEMBL4203 | Q9HAZ1 | Dual specificity protein kinase CLK4 | 87.53% | 94.45% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 86.72% | 96.09% |
| CHEMBL1293249 | Q13887 | Kruppel-like factor 5 | 85.59% | 86.33% |
| CHEMBL2955 | O95136 | Sphingosine 1-phosphate receptor Edg-5 | 84.96% | 92.86% |
| CHEMBL4793 | Q86TI2 | Dipeptidyl peptidase IX | 84.86% | 96.95% |
| CHEMBL2274 | Q9H228 | Sphingosine 1-phosphate receptor Edg-8 | 83.46% | 100.00% |
| CHEMBL4657 | Q6V1X1 | Dipeptidyl peptidase VIII | 82.25% | 97.21% |
| CHEMBL5805 | Q9NR97 | Toll-like receptor 8 | 80.77% | 96.25% |
| CHEMBL5845 | P23415 | Glycine receptor subunit alpha-1 | 80.75% | 90.71% |
| CHEMBL3892 | Q99500 | Sphingosine 1-phosphate receptor Edg-3 | 80.52% | 97.29% |
| CHEMBL5163 | Q9NY46 | Sodium channel protein type III alpha subunit | 80.21% | 96.90% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| Cannabis sativa |
| Helichrysum umbraculigerum |
| PubChem | 5315659 |
| NPASS | NPC201662 |
| ChEMBL | CHEMBL497318 |
| LOTUS | LTS0069129 |
| wikiData | Q412122 |