Benzyl Isothiocyanate
| Internal ID | b536fbdb-46ae-45f8-a515-c93df36378a5 |
| Taxonomy | Benzenoids > Benzene and substituted derivatives |
| IUPAC Name | isothiocyanatomethylbenzene |
| SMILES (Canonical) | C1=CC=C(C=C1)CN=C=S |
| SMILES (Isomeric) | C1=CC=C(C=C1)CN=C=S |
| InChI | InChI=1S/C8H7NS/c10-7-9-6-8-4-2-1-3-5-8/h1-5H,6H2 |
| InChI Key | MDKCFLQDBWCQCV-UHFFFAOYSA-N |
| Popularity | 1,010 references in papers |
| Molecular Formula | C8H7NS |
| Molecular Weight | 149.21 g/mol |
| Exact Mass | 149.02992040 g/mol |
| Topological Polar Surface Area (TPSA) | 44.40 Ų |
| XlogP | 3.20 |
| Atomic LogP (AlogP) | 2.29 |
| H-Bond Acceptor | 2 |
| H-Bond Donor | 0 |
| Rotatable Bonds | 2 |
| 622-78-6 |
| Benzylisothiocyanate |
| (Isothiocyanatomethyl)benzene |
| Benzylsenfoel |
| Tromacaps |
| Tromalyt |
| Urogran |
| Isothiocyanic acid, benzyl ester |
| Benzene, (isothiocyanatomethyl)- |
| Benzyl-isothiocyanate |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9748 | 97.48% |
| Caco-2 | + | 0.9231 | 92.31% |
| Blood Brain Barrier | + | 0.9750 | 97.50% |
| Human oral bioavailability | + | 0.8429 | 84.29% |
| Subcellular localzation | Lysosomes | 0.5012 | 50.12% |
| OATP2B1 inhibitior | - | 1.0000 | 100.00% |
| OATP1B1 inhibitior | + | 0.9507 | 95.07% |
| OATP1B3 inhibitior | + | 0.9532 | 95.32% |
| MATE1 inhibitior | - | 1.0000 | 100.00% |
| OCT2 inhibitior | - | 0.6750 | 67.50% |
| BSEP inhibitior | - | 0.9234 | 92.34% |
| P-glycoprotein inhibitior | - | 0.9847 | 98.47% |
| P-glycoprotein substrate | - | 0.9707 | 97.07% |
| CYP3A4 substrate | - | 0.7423 | 74.23% |
| CYP2C9 substrate | - | 1.0000 | 100.00% |
| CYP2D6 substrate | - | 0.6593 | 65.93% |
| CYP3A4 inhibition | - | 0.7009 | 70.09% |
| CYP2C9 inhibition | - | 0.8474 | 84.74% |
| CYP2C19 inhibition | - | 0.6514 | 65.14% |
| CYP2D6 inhibition | - | 0.7218 | 72.18% |
| CYP1A2 inhibition | + | 0.8543 | 85.43% |
| CYP2C8 inhibition | - | 0.7882 | 78.82% |
| CYP inhibitory promiscuity | + | 0.6066 | 60.66% |
| UGT catelyzed | - | 0.0000 | 0.00% |
| Carcinogenicity (binary) | - | 0.5000 | 50.00% |
| Carcinogenicity (trinary) | Non-required | 0.7455 | 74.55% |
| Eye corrosion | + | 0.9798 | 97.98% |
| Eye irritation | + | 0.9664 | 96.64% |
| Skin irritation | + | 0.9121 | 91.21% |
| Skin corrosion | + | 0.9603 | 96.03% |
| Ames mutagenesis | + | 0.5900 | 59.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.7388 | 73.88% |
| Micronuclear | - | 0.7200 | 72.00% |
| Hepatotoxicity | + | 0.7626 | 76.26% |
| skin sensitisation | + | 0.8216 | 82.16% |
| Respiratory toxicity | - | 0.5444 | 54.44% |
| Reproductive toxicity | - | 0.8000 | 80.00% |
| Mitochondrial toxicity | + | 0.8000 | 80.00% |
| Nephrotoxicity | - | 0.6142 | 61.42% |
| Acute Oral Toxicity (c) | II | 0.6499 | 64.99% |
| Estrogen receptor binding | - | 0.6374 | 63.74% |
| Androgen receptor binding | - | 0.8590 | 85.90% |
| Thyroid receptor binding | - | 0.8353 | 83.53% |
| Glucocorticoid receptor binding | - | 0.6682 | 66.82% |
| Aromatase binding | - | 0.6246 | 62.46% |
| PPAR gamma | - | 0.5668 | 56.68% |
| Honey bee toxicity | - | 0.7870 | 78.70% |
| Biodegradation | - | 0.5000 | 50.00% |
| Crustacea aquatic toxicity | + | 0.7900 | 79.00% |
| Fish aquatic toxicity | + | 0.7614 | 76.14% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL1293255 | P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD+] |
31622.8 nM |
Potency |
via CMAUP
|
| CHEMBL3577 | P00352 | Aldehyde dehydrogenase 1A1 |
2818.4 nM |
Potency |
via CMAUP
|
| CHEMBL340 | P08684 | Cytochrome P450 3A4 |
25118.9 nM 25118.9 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL2085 | P14174 | Macrophage migration inhibitory factor |
530 nM 540 nM 530 nM |
IC50 IC50 IC50 |
PMID: 25743213
PMID: 25743213 via Super-PRED |
| CHEMBL6007 | O75762 | Transient receptor potential cation channel subfamily A member 1 |
250 nM 319 nM 250 nM 10964.78 nM 23988.33 nM 15488.17 nM 27542.29 nM |
EC50 EC50 EC50 EC50 EC50 EC50 EC50 |
via Super-PRED
PMID: 20356305 PMID: 26263397 PMID: 20806939 PMID: 20806939 PMID: 20806939 PMID: 20806939 |
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL221 | P23219 | Cyclooxygenase-1 | 91.97% | 90.17% |
| CHEMBL2035 | P08912 | Muscarinic acetylcholine receptor M5 | 91.12% | 94.62% |
| CHEMBL2581 | P07339 | Cathepsin D | 89.59% | 98.95% |
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 83.58% | 91.11% |
| CHEMBL3227 | P41594 | Metabotropic glutamate receptor 5 | 82.11% | 96.42% |
| CHEMBL240 | Q12809 | HERG | 81.76% | 89.76% |
| CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 81.24% | 95.56% |
| CHEMBL216 | P11229 | Muscarinic acetylcholine receptor M1 | 81.20% | 94.23% |
| CHEMBL3902 | P09211 | Glutathione S-transferase Pi | 81.10% | 93.81% |
| CHEMBL1293249 | Q13887 | Kruppel-like factor 5 | 80.79% | 86.33% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| PubChem | 2346 |
| NPASS | NPC299134 |
| ChEMBL | CHEMBL55285 |
| LOTUS | LTS0228692 |
| wikiData | Q18341725 |