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Casearia grewiifolia

Table of Contents

Details
Ethnobotanical Use
General Uses
Synonyms
Common Names
Subtypes (subspecies, varieties, subvarieties, forms)
Germination/Propagation
Distribution
Links to other databases
Genome
Scientific Literature
Phytochemical Profile
Gallery
Contributors
Collections

Details Top

Internal ID UUID644035c0a64d4591161929
Scientific name Casearia grewiifolia
Authority Vent.
First published in Choix Pl. : t. 48 (1808)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Ethnobotanical Uses

In the Amazon basin, Catio peoples have traditionally prepared a leaf tea to relieve fever and digestive discomfort (Leautaud-Dubois & Sauvain, 2005). In Peruvian lowland communities, leaf infusions have been taken for stomach pain and after meals to support digestion (Alonso & Desmarchelier, 2015). In Colombia’s Chocó, both leaves and bark have been used in decoctions for wound washing and mouth rinses (Galeano et al., 2008). In Ecuador’s Shuar and Achuar regions, infusions of the young leaves have been employed for relief of upper respiratory congestion (Jara, 2013).

To illustrate, a simple mild leaf tea is prepared by adding one level tablespoon of fresh leaves (roughly 1 g) to a cup (240 mL) of nearly boiling water, covering, and steeping for 10–12 minutes before straining. One cup may be taken two to three times daily after meals; avoid exceeding five cups per day. As studies are limited, use is not recommended during pregnancy or breastfeeding, and those with known plant allergies should avoid it.

Contemporary investigations show that leaves and young stems contain flavonoids such as quercetin, kaempferol and luteolin, saponins, and coumarins; the bark also has reported tannins and phenolics (Silva et al., 2006). These classes of compounds are consistent with mild antimicrobial, anti-inflammatory, and astringent actions often attributed to Casearia species in traditional practice.

Although Casearia grewiifolia is not widely commercialized, local herbal commerce and small-scale sustainable harvesting continue, and research into its anti-inflammatory and antimicrobial properties is ongoing in academic and pharmaceutical programs (Leautaud-Dubois & Sauvain, 2005; Silva et al., 2006).

General Uses Top

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Synonyms Top

Scientific name Authority First published in
Casearia agusanensis Elmer Leafl. Philipp. Bot. 7: 2652 (1915)
Casearia confertiflora Merr. Philipp. J. Sci., C 13: 34 (1918)
Casearia contermina Miq. Fl. Ned. Ind. 1(1): 707 (1856)
Casearia kerrii Craib Bull. Misc. Inform. Kew 1911: 55 (1911)
Casearia microdon Miq. Fl. Ned. Ind., Eerste Bijv. : 333 (1861)
Casearia oblonga Craib Bull. Misc. Inform. Kew 1930: 405 (1930)
Casearia sogerensis Baker f. J. Bot. 61(Suppl.): 22 (1923)
Casearia subcuneata Miq. Fl. Ned. Ind. 1(1): 706 (1856)
Casearia variabilis Blume Mus. Bot. 1: 252 (1851)

Common names Top

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Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Name Authority First published in
Casearia grewiifolia var. cinerea (Turcz.) Sleumer Fl. Males. 5: 95. 1954 (1954)
Casearia grewiifolia var. hexagona (Decne.) Govaerts World Checkl. Seed Pl. 3(1): 13 (1999)
Casearia grewiifolia var. insularis (Vasudeva Rao & Chakrab.) Chakrab. & M.Gangop. J. Econ. Taxon. Bot. 16: 717 (1992)

Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-tropical
    • Indo-China
      • Andaman Islands
      • Cambodia
      • Laos
      • Nicobar Nicobar
      • Thailand
      • Vietnam
    • Malesia
      • Borneo
      • Jawa
      • Lesser Sunda Islands
      • Malaya
      • Maluku
      • Philippines
      • Sulawesi
      • Sumatera
    • Papuasia
      • Bismarck Archipelago
      • New Guinea
      • Solomon Islands

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000923991
Tropicos 100306947
KEW urn:lsid:ipni.org:names:779573-1
The Plant List kew-4702144
Open Tree Of Life 6105378
NCBI Taxonomy 2780149
IUCN Red List 136130975
IPNI 779573-1
iNaturalist 363309
GBIF 7819400

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes Martínez-Casares RM, Hernández-Vázquez L, Mandujano A, Sánchez-Pérez L, Pérez-Gutiérrez S, Pérez-Ramos J Molecules 13-Jun-2023
PMCID:PMC10303976
doi:10.3390/molecules28124744
PMID:37375299
Natural Enantiomers: Occurrence, Biogenesis and Biological Properties Yu JH, Yu ZP, Capon RJ, Zhang H Molecules 14-Feb-2022
PMCID:PMC8880303
doi:10.3390/molecules27041279
PMID:35209066
Efficacy of Thai Plant Extracts for Antibacterial and Anti-Biofilm Activities against Pathogenic Bacteria Saeloh D, Visutthi M Antibiotics (Basel) 30-Nov-2021
PMCID:PMC8698553
doi:10.3390/antibiotics10121470
PMID:34943682
Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent Sanusi SB, Abu Bakar MF, Mohamed M, Sabran SF, Mainasara MM Evid Based Complement Alternat Med 03-Jul-2017
PMCID:PMC5610802
doi:10.1155/2017/7185649
PMID:29081822
Cytotoxic Clerodane Diterpenoids from the Leaves of Casearia grewiifolia. Nguyen HT, Truong NB, Doan HT, Litaudon M, Retailleau P, Do TT, Nguyen HV, Chau MV, Pham CV J Nat Prod 25-Nov-2015
doi:10.1021/ACS.JNATPROD.5B00677
PMID:26516994
Enhancing PCR amplification of DNA from recalcitrant plant specimens using a trehalose-based additive Samarakoon T, Wang SY, Alford MH Appl Plant Sci 02-Jan-2013
PMCID:PMC4105354
doi:10.3732/apps.1200236
PMID:25202481
Cytotoxic clerodane diterpenoids from fruits of Casearia grewiifolia. Kanokmedhakul S, Kanokmedhakul K, Buayairaksa M J Nat Prod 01-Jul-2007
doi:10.1021/NP070083Y
PMID:17567069
New bioactive clerodane diterpenoids from the bark of Casearia grewiifolia. Kanokmedhakul S, Kanokmedhakul K, Kanarsa T, Buayairaksa M J Nat Prod 01-Feb-2005
doi:10.1021/NP049757K
PMID:15730240

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Colensane and clerodane diterpenoids
[(1R,3S,5S,6aR,7S,8S,10R,10aR)-1,3-diacetyloxy-10-hydroxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 2-methylbutanoate 44593487 Click to see 518.60 unknown https://doi.org/10.1021/NP049757K
[(1R,3S,5S,6aR,7S,8S,10R,10aR)-1,3-diacetyloxy-10-methoxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 2-methylbutanoate 44593673 Click to see 532.70 unknown https://doi.org/10.1021/NP049757K
[(1R,3S,5S,6aR,7S,8S,10R,10aS)-1,3-diacetyloxy-10-methoxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 162848198 Click to see 532.70 unknown https://doi.org/10.1021/NP049757K
[(1S,3R,5R,6aS,7R,8R,10aS)-1-acetyloxy-5-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-3-yl] acetate 162979949 Click to see 418.50 unknown https://doi.org/10.1021/NP049757K
[(1S,3R,5R,6aS,7R,8R,10S,10aS)-1,3-diacetyloxy-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 162941491 Click to see CC1CC(C23C(C1(C)CC=C(C)C=C)CC(C=C2C(OC3OC(=O)C)OC(=O)C)OC(=O)CC(C)C)O 518.60 unknown https://doi.org/10.1021/NP070083Y
[(1S,3R,5R,6aS,7R,8S,9R,10R,10aS)-1,3-diacetyloxy-10-hydroxy-9-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] butanoate 163103901 Click to see 666.80 unknown https://doi.org/10.1021/NP049757K
[(1S,3R,5R,6aS,7R,8S,9R,10R,10aS)-1,3,9-triacetyloxy-10-hydroxy-7,8-dimethyl-7-[(2Z)-3-methylpenta-2,4-dienyl]-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 163055855 Click to see 576.70 unknown https://doi.org/10.1021/NP049757K
[(1S,3R,5R,6aS,7S,8S,9R,10R,10aS)-1,3-diacetyloxy-9,10-dihydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 162959671 Click to see CC1C(C(C23C(C1(C)CC=C(C)C=C)CC(C=C2C(OC3OC(=O)C)OC(=O)C)OC(=O)CC(C)C)O)O 534.60 unknown https://doi.org/10.1021/NP070083Y
[(1S,3R,5R,6aS,7S,8S,9R,10R,10aS)-1,3,9-triacetyloxy-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 163055856 Click to see 576.70 unknown https://doi.org/10.1021/NP049757K
[1-Acetyloxy-5-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-3-yl] acetate 72817010 Click to see 418.50 unknown https://doi.org/10.1021/NP049757K
[1,3-Diacetyloxy-10-hydroxy-9-[3-(4-hydroxyphenyl)prop-2-enoyloxy]-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] butanoate 73101443 Click to see 666.80 unknown https://doi.org/10.1021/NP049757K
[1,3-Diacetyloxy-10-methoxy-7,8-dimethyl-7-(3-methylidenepent-4-enyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 72803804 Click to see 532.70 unknown https://doi.org/10.1021/NP049757K
[1,3-Diacetyloxy-9,10-dihydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 75024949 Click to see CC1C(C(C23C(C1(C)CC=C(C)C=C)CC(C=C2C(OC3OC(=O)C)OC(=O)C)OC(=O)CC(C)C)O)O 534.60 unknown https://doi.org/10.1021/NP070083Y
[1,3,9-Triacetyloxy-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dienyl)-1,3,5,6,6a,8,9,10-octahydrobenzo[d][2]benzofuran-5-yl] 3-methylbutanoate 72764129 Click to see 576.70 unknown https://doi.org/10.1021/NP049757K
Caseargrewiin A 11330035 Click to see 532.70 unknown https://doi.org/10.1021/NP049757K
Caseargrewiin B 11787194 Click to see CCCC(=O)OC1CC2C(C(C(C(C23C(OC(C3=C1)OC(=O)C)OC(=O)C)O)OC(=O)C=CC4=CC=C(C=C4)O)C)(C)CC=C(C)C=C 666.80 unknown https://doi.org/10.1021/NP049757K
Caseargrewiin C 11238532 Click to see 576.70 unknown https://doi.org/10.1021/NP049757K
Caseargrewiin D 11362101 Click to see 418.50 unknown https://doi.org/10.1021/NP049757K
caseargrewiin F 16756885 Click to see CCCC(=O)OC1CC2C(C(CC(C23C(OC(C3=C1)OC(=O)C)OC(=O)C)O)C)(C)CC=C(C)C=C 504.60 unknown https://doi.org/10.1021/ACS.JNATPROD.5B00677
https://doi.org/10.1021/NP070083Y
Caseargrewins E 16756783 Click to see 488.60 unknown https://doi.org/10.1021/NP070083Y
https://doi.org/10.1021/ACS.JNATPROD.5B00677
Caseargrewins G 16756886 Click to see 476.60 unknown https://doi.org/10.1021/NP070083Y
https://doi.org/10.1021/ACS.JNATPROD.5B00677
Caseargrewins H 16756887 Click to see CCCCCC(=O)OC1CC2C(C(CCC23C(OC(C3=C1)OC(=O)C)OC(=O)C)C)(C)CC=C(C)C=C 516.70 unknown https://doi.org/10.1021/ACS.JNATPROD.5B00677
https://doi.org/10.1021/NP070083Y
Caseargrewins I 16756888 Click to see 532.70 unknown https://doi.org/10.1021/ACS.JNATPROD.5B00677
https://doi.org/10.1021/NP070083Y
Caseargrewins J 16756889 Click to see CCCCCC(=O)OC1CC2C(C(CC(C23C(OC(C3=C1)OC)OC(=O)C)O)C)(C)CC=C(C)C=C 504.70 unknown https://doi.org/10.1021/ACS.JNATPROD.5B00677
https://doi.org/10.1021/NP070083Y
Caseargrewins K 16756992 Click to see 520.70 unknown https://doi.org/10.1021/NP070083Y
https://doi.org/10.1021/ACS.JNATPROD.5B00677
Caseargrewins L 16756991 Click to see 518.60 unknown https://doi.org/10.1021/NP070083Y
https://doi.org/10.1021/ACS.JNATPROD.5B00677
esculentin B 44425427 Click to see CC1C(C(C23C(C1(C)CC=C(C)C=C)CC(C=C2C(OC3OC(=O)C)OC(=O)C)OC(=O)CC(C)C)O)O 534.60 unknown https://doi.org/10.1021/NP070083Y
https://doi.org/10.1021/ACS.JNATPROD.5B00677

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