Isodon rugosus serves as a natural source of ent-kaurane diterpenoids, especially oridonin, and is used to study diterpenoid biosynthesis, metabolism, and plant–microbe interactions; plant material is cultivated in experimental plots or sourced from wild stands for phytochemical analyses, bioassays, and chemical database entries (e.g., PubChem CID 110058 for oridonin); voucher specimens are deposited in herbaria to anchor taxonomic identity in published studies.

Key physical/chemical properties enabling its experimental use include the presence of ent-kaurane diterpenoid oridonin (a tetracyclic diterpene), a set of related diterpenoids with similar carbon frameworks and functionality, and taxa-specific chemotypes that generate reproducible profiles; standardized extraction, fractionation, and dereplication protocols are employed to isolate and characterize these compounds for analytical databases.

Synonyms Top

Scientific name	Authority	First published in
Isodon plectranthoides	Schrad. ex Benth.	Labiat. Gen. Spec. : 43 (1832)
Lumnitzera densiflora	(Roth) Spreng.	Syst. Veg., ed. 16 [Sprengel] 2: 687. 1825 [Jan-May 1825]
Ocimum densiflorum	Roth	Nov. Pl. Sp. : 275 (1821)
Plectranthus rugosus	Wall. ex Benth.	Pl. Asiat. Rar. 2: 17 (1830)
Rabdosia rugosa	(Wall. ex Benth.) H.Hara	J. Jap. Bot. 47: 199 (1972)

Common names Top

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Filter by language:

Language	Common/alternative name
Chinese	皱叶香茶菜

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:

- Doubtful data

- Extinct

- Introduced

- Native

Asia-temperate click to expand
- Arabian Peninsula
  - Oman
- China
  - Tibet
- Western Asia
  - Afghanistan

Asia-tropical click to expand
- Indian Subcontinent
  - Bangladesh
  - East Himalaya
  - Nepal
  - Pakistan
  - West Himalaya

Links to other databases Top

Suggest others/fix!

Database	ID/link to page
World Flora Online	wfo-0000217958
Tropicos	17607203
KEW	urn:lsid:ipni.org:names:448611-1
The Plant List	kew-103022
Open Tree Of Life	23547
NCBI Taxonomy	204135
IPNI	448611-1
iNaturalist	126049
GBIF	5608857
EOL	2898985
USDA GRIN	407617

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.

Title

Authors

Publication

Released

IDs

Vegetation–edaphic correlation and importance value index in himalayan ‘ecotone’ temperate conifer forest using the multivariate technique

Ali F, Zeb M, Amin M, Rajpar MN, Hidayat S, Khan WR

Saudi J Biol Sci

24-Mar-2024

PMCID:	PMC11000104
doi:	10.1016/j.sjbs.2024.103983
PMID:	38590389

Habitat suitability modelling of Koklass pheasant (Pucrasia macrolopha) in moist temperate forest

Badrulislam, Khan KA, Khalil S, Hussain M, Saqib Z, Altaf J, Hadi R, Habiba U

PLoS One

15-Feb-2024

PMCID:	PMC10868740
doi:	10.1371/journal.pone.0296921
PMID:	38359051

Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

Alshehri OM, Zeb A, Mukarram Shah SM, Mahnashi MH, Asiri SA, Alqahtani O, Sadiq A, Ibrar M, Alshamrani S, Jan MS

Front Pharmacol

13-Feb-2024

PMCID:	PMC10897015
doi:	10.3389/fphar.2024.1328128
PMID:	38414736

Ethno-Dentistry of Medicinal Plants Used in North Waziristan, Pakistan

Rehman S, Iqbal Z, Qureshi R, AlOmar TS, Almasoud N, Younas M, Rauf A, Irfan M

Int Dent J

11-Nov-2023

PMCID:	PMC10988256
doi:	10.1016/j.identj.2023.10.001
PMID:	37953188

Ethnobotanical Insights into Medicinal and Culinary Plant Use: The Dwindling Traditional Heritage of the Dard Ethnic Group in the Gurez Region of the Kashmir Valley, India

Ahad L, Hassan M, Amjad MS, Mir RA, Vitasović-Kosić I, Bussmann RW, Binish Z

Plants (Basel)

17-Oct-2023

PMCID:	PMC10610420
doi:	10.3390/plants12203599
PMID:	37896062

The Optimization of Medium Conditions and Auxins in the Induction of Adventitious Roots of Pokeweed (Phytolacca americana L.) and Their Phytochemical Constituents

Trunjaruen A, Luecha P, Taratima W

Scientifica (Cairo)

21-Aug-2023

PMCID:	PMC10462441
doi:	10.1155/2023/2983812
PMID:	37645570

Application of Rosmarinic Acid with Its Derivatives in the Treatment of Microbial Pathogens

Kernou ON, Azzouz Z, Madani K, Rijo P

Molecules

22-May-2023

PMCID:	PMC10220798
doi:	10.3390/molecules28104243
PMID:	37241981

Traditional foraging for ecological transition? Wild food ethnobotany among three ethnic groups in the highlands of the eastern Hindukush, North Pakistan

Khan AH, Adil M, Aziz MA, Sõukand R, Pieroni A

J Ethnobiol Ethnomed

31-Mar-2023

PMCID:	PMC10064566
doi:	10.1186/s13002-023-00581-9
PMID:	37004043

Natural product-driven dual COX-LOX inhibitors: Overview of recent studies on the development of novel anti-inflammatory agents

Mukhopadhyay N, Shukla A, Makhal PN, Kaki VR

Heliyon

14-Mar-2023

PMCID:	PMC10068128
doi:	10.1016/j.heliyon.2023.e14569
PMID:	37020932

Exploring soil bacterial diversity in different micro-vegetational habitats of Dachigam National Park in North-western Himalaya

Mushtaq H, Ganai BA, Jehangir A

Sci Rep

22-Feb-2023

PMCID:	PMC9947166
doi:	10.1038/s41598-023-30187-w
PMID:	36813837

Evaluation of Senna tora (L.) Roxb. leaves as source of bioactive molecules with antioxidant, anti-inflammatory and antibacterial potential

Rahman MM, Al Noman MA, Khatun S, Alam R, Shetu MM, Talukder EK, Imon RR, Biswas MY, Anis-Ul-Haque KM, Uddin MJ, Akhter S

Heliyon

19-Jan-2023

PMCID:	PMC9898628
doi:	10.1016/j.heliyon.2023.e12855
PMID:	36747926

Antibacterial and Photodegradation of Organic Dyes Using Lamiaceae-Mediated ZnO Nanoparticles: A Review

Mutukwa D, Taziwa RT, Khotseng L

Nanomaterials (Basel)

16-Dec-2022

PMCID:	PMC9785588
doi:	10.3390/nano12244469
PMID:	36558321

A Cross-Cultural Analysis of Medicinal Plant Utilization among the Four Ethnic Communities in Northern Regions of Jammu and Kashmir, India

Mir TA, Jan M, Jan HA, Bussmann RW, Sisto F, Fadlalla IM

Biology (Basel)

27-Oct-2022

PMCID:	PMC9687545
doi:	10.3390/biology11111578
PMID:	36358279

Herbal Arsenal against Skin Ailments: A Review Supported by In Silico Molecular Docking Studies

Singab AN, Mostafa NM, Fawzy IM, Bhatia D, Suryawanshi PT, Kabra A

Molecules

21-Sep-2022

PMCID:	PMC9572213
doi:	10.3390/molecules27196207
PMID:	36234737

A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight

Guan H, Luo W, Bao B, Cao Y, Cheng F, Yu S, Fan Q, Zhang L, Wu Q, Shan M

Molecules

20-May-2022

PMCID:	PMC9143754
doi:	10.3390/molecules27103292
PMID:	35630768

Phytochemical Profile Top

Add a new one!

Below are displayed the proven (via scientific papers) natural compounds!
You can also contribute to this by clicking here.

Name	PubChem ID	Canonical SMILES	MW	Found in	Proof
> Lipids and lipid-like molecules / Prenol lipids / Diterpenoids / Kaurane diterpenoids
(1S,2S,8R,9S,11R)-9,10,15,18-tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one	138107787	Click to see	364.40	unknown	https://doi.org/10.1055/S-2003-38889
(1S,4aR,5S,6S,6aR,9S,11aS,11bS,14R)-5,6,14-Trihydroxy-4,4-dimethyl-8-methylene-7-oxododecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-1-yl acetate	12305580	Click to see	406.50	unknown	https://doi.org/10.1055/S-2003-38889
(9,10-Dihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl) acetate	10475500	Click to see	390.50	unknown	https://doi.org/10.1055/S-2003-38889
(9,10,18-Trihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo(7.6.2.15,8.01,11.02,8)octadecan-15-yl) acetate	429192	Click to see	406.50	unknown	https://doi.org/10.1055/S-2003-38889 https://doi.org/10.1021/NP200140J
[(1R,2R,5S,8R,9R,10R,11S,15R)-9,10-dihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate	125463139	Click to see	390.50	unknown	https://doi.org/10.1055/S-2003-38889
[(1S,2S,5R,10S,11R,15S,18R)-9,10,18-trihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate	6325508	Click to see CC(=O)OC1CCC(C2C13COC(C2O)(C45C3CCC(C4O)C(=C)C5=O)O)(C)C	406.50	unknown	https://doi.org/10.1021/NP200140J https://doi.org/10.1055/S-2003-37031-2
[(2S,5S,9S,10R,11R,15R,18R)-9,10,18-trihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate	101306857	Click to see	406.50	unknown	https://doi.org/10.1055/S-2003-38889
3,9,10,15-Tetrahydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one	12305578	Click to see	364.40	unknown	https://doi.org/10.1016/J.PHYTOCHEM.2004.02.022 https://doi.org/10.1055/S-2003-38889
9,10,15-Trihydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-7-one	9997896	Click to see	348.40	unknown	https://doi.org/10.1055/S-2003-38889
CID 34174831	34174831	Click to see	390.50	unknown	https://doi.org/10.1055/S-2003-38889
Effusanin A	34174827	Click to see	348.40	unknown	https://doi.org/10.1055/S-2003-38889
Effusanin E	24721137	Click to see CC1(CCC(C23C1C(C(C45C2C(CC(C4)C(=C)C5=O)O)(OC3)O)O)O)C	364.40	unknown	https://doi.org/10.1055/S-2003-38889
Oridonin	5321010	Click to see CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C	364.40	unknown	https://doi.org/10.1055/S-2003-38889
Rubescensin A	3576890	Click to see CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C	364.40	unknown	https://doi.org/10.1055/S-2003-38889
> Lipids and lipid-like molecules / Prenol lipids / Triterpenoids
(1R,2S,4aR,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-hydroxy-1,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-2-carboxylic acid	101643020	Click to see	456.70	unknown	https://doi.org/10.1016/0040-4020(82)85077-1
(1S,2R,4aR,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-1-carboxylic acid	162883244	Click to see	498.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
(1S,2R,4aR,6aR,6aS,6bR,8aR,10R,12aR,14bS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-1-carboxylic acid	154731119	Click to see CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C(=O)O)C)C	456.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
(1S,2S,4aR,6aR,6aR,6bR,8aR,10R,12aR,14bS)-10-hydroxy-1,2,4a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-6a-carboxylic acid	163026022	Click to see	456.70	unknown	https://doi.org/10.1016/0040-4020(82)85077-1
(3R,4aR,6aR,6bS,8aR,11R,12S,12aS,14aR,14bR)-12-(hydroxymethyl)-4,4,6a,6b,8a,11,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol	163079620	Click to see	442.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-1-carboxylic acid	162883243	Click to see	498.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
10-hydroxy-1,2,4a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-6a-carboxylic acid	12314030	Click to see	456.70	unknown	https://doi.org/10.1016/0040-4020(82)85077-1
10-hydroxy-1,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-2-carboxylic acid	124222330	Click to see	456.70	unknown	https://doi.org/10.1016/0040-4020(82)85077-1
10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-1-carboxylic acid	3515456	Click to see CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C(=O)O)C)C	456.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
12-(hydroxymethyl)-4,4,6a,6b,8a,11,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol	163079618	Click to see	442.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
> Lipids and lipid-like molecules / Steroids and steroid derivatives / Stigmastanes and derivatives
(-)-beta-Sitosterol	222284	Click to see	414.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4
17-(5-ethyl-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol	86821	Click to see CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C	414.70	unknown	https://doi.org/10.1016/S0031-9422(00)95277-4

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Isodon rugosus

Table of Contents

Details Top

Ethnobotanical Use Top

General Uses Top

Synonyms Top

Common names Top

Subspecies (abbr. subsp./ssp.) Top

Varieties (abbr. var.) Top

Subvarieties (abbr. subvar.) Top

Forms (abbr. f.) Top

Germination/Propagation Top

Distribution (via POWO/KEW) Top

Links to other databases Top

Genomes (via NCBI) Top

Scientific Literature Top

Phytochemical Profile Top

Gallery Top

Contributors Top

Collections Top