Strychnos toxifera - Unknown
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Internal ID UUID644004bb18c4e213262005
Scientific name Strychnos toxifera
Authority Schomburgk ex Lindl.
First published in Fl. Med. : 530 (1838)

Description Top

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Strychnos toxifera, also known as bush rope and devil doer, is a flowering plant found in various countries in South America. It is a major source of calabash or gourd curare, a substance used as a muscle relaxant and poison by indigenous people. The plant also contains an alkaloid called Macusine B, which acts as an inhibitor of adrenergic alpha-receptors and tryptamine receptors. This compound can be extracted from Strychnos toxifera and has potential medical applications.

Synonyms Top

Scientific name Authority First published in
Strychnos syntoxica Sprague & Sandwith Bull. Misc. Inform. Kew 1927: 129 (1927)

Common names Top

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Language Common/alternative name
English strychnine
Czech kulčiba jedodárná
Hebrew סטריכנוס טוקסיפרה
Malayalam സ്ട്രൈക്നോസ് ടോക്സിഫെറ

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Southern America
    • Brazil
      • Brazil North
    • Central America
      • Costa Rica
      • Panamá
    • Northern South America
      • French Guiana
      • Guyana
      • Suriname
      • Venezuela
    • Western South America
      • Bolivia
      • Colombia
      • Ecuador

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000501258
USDA Plants STTO6
Tropicos 19000576
INPN 733964
KEW urn:lsid:ipni.org:names:547525-1
The Plant List kew-2595066
Open Tree Of Life 1077134
NCBI Taxonomy 1040935
IPNI 547525-1
GBIF 5414401
EPPO SYHTO
EOL 483954
USDA GRIN 312989
Wikipedia Strychnos_toxifera

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
A comprehensive review on the medicinally valuable endosymbiotic fungi Penicillium chrysogenum Shaaban R, Elnaggar MS, Khalil N, Singab AN Arch Microbiol 17-May-2023
PMCID:PMC10191097
doi:10.1007/s00203-023-03580-2
PMID:37195521
Metabolic Profiling and In Vitro Assessment of the Biological Activities of the Ethyl Acetate Extract of Penicillium chrysogenum “Endozoic of Cliona sp. Marine Sponge” from the Red Sea (Egypt) Al-Saleem MS, Hassan WH, El Sayed ZI, Abdel-Aal MM, Abdel-Mageed WM, Abdelsalam E, Abdelaziz S Mar Drugs 15-May-2022
PMCID:PMC9143181
doi:10.3390/md20050326
PMID:35621977
Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development Yeshi K, Crayn D, Ritmejerytė E, Wangchuk P Molecules 05-Jan-2022
PMCID:PMC8746929
doi:10.3390/molecules27010313
PMID:35011546
Natural Antispasmodics: Source, Stereochemical Configuration, and Biological Activity Martínez-Pérez EF, Juárez ZN, Hernández LR, Bach H Biomed Res Int 08-Oct-2018
PMCID:PMC6196993
doi:10.1155/2018/3819714
PMID:30402474
Military Importance of Natural Toxins and Their Analogs Pitschmann V, Hon Z Molecules 28-Apr-2016
PMCID:PMC6273326
doi:10.3390/molecules21050556
PMID:27136512
Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M2 Receptors Zlotos DP, Tränkle C, Holzgrabe U, Gündisch D, Jensen AA J Nat Prod 05-Sep-2014
PMCID:PMC4176391
doi:10.1021/np500259j
PMID:25192059
Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research SATO F, KUMAGAI H Proc Jpn Acad Ser B Phys Biol Sci 10-May-2013
PMCID:PMC3722365
doi:10.2183/pjab.89.165
PMID:23666088
C Lackie JM The Dictionary of Cell & Molecular Biology 04-Jan-2013
PMCID:PMC7149705
doi:10.1016/B978-0-12-384931-1.00003-9
Interfacial inhibitors: targeting macromolecular complexes Pommier Y, Marchand C Nat Rev Drug Discov 16-Dec-2011
PMCID:PMC7380715
doi:10.1038/nrd3404
PMID:22173432
Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect Rufener L, Keiser J, Kaminsky R, Mäser P, Nilsson D PLoS Pathog 09-Sep-2010
PMCID:PMC2936538
doi:10.1371/journal.ppat.1001091
PMID:20838602
Curare and a Canadian connection Czarnowski C, Bailey J, Bal S Can Fam Physician 01-Sep-2007
PMCID:PMC2234642
Isolation and purification of panarine, A. Alkaloid from a Venezuelan Curare J. Quetin-Leclercq, L. Ancenot, L. Dupont, N.G. Bisset Elsevier BV 25-Jul-2002
doi:10.1016/0031-9422(88)83075-9
Waterton and Wouralia Birmingham AT Br J Pharmacol 01-Apr-1999
PMCID:PMC1565951
doi:10.1038/sj.bjp.0702409
PMID:10372809

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives / Macroline alkaloids
CID 6441303 6441303 Click to see CC=C1C[N+]2(C3CC1C(C2CC4=C3NC5=CC=CC=C45)CO)C 309.40 unknown https://doi.org/10.1016/0031-9422(88)83075-9
Panarine 134716681 Click to see CC=C1C[N+]2(C3CC1C(C2CC4=C3NC5=CC=CC=C45)C(=O)[O-])C 322.40 unknown https://doi.org/10.1016/0031-9422(88)83075-9
> Organic acids and derivatives / Carboxylic acids and derivatives / Carboxylic acid derivatives / Carboxylic acid esters
2-aminoethyl Acetate 112720 Click to see CC(=O)OCCN 103.12 unknown https://doi.org/10.1016/0031-9422(88)83075-9

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