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Internal ID UUID643fdbd0babf0063219877
Scientific name Cyclopia subternata
Authority Vogel
First published in Linnaea10: 595 (1836)

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Synonyms Top

Scientific name Authority First published in
Cyclopia grandiflora A.DC. Pl. Rar. Jard. Genève8: 29
Cyclopia grandifolia Benth. London J. Bot.2: 432 (1843)
Cyclopia vogelii var. subternata (Vogel) Harv. W.H.Harvey & auct. suc. (eds.), Fl. Cap.1: 6 (1862)

Common names Top

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Language Common/alternative name
English honeybush-tea
Afrikaans heuningbostee
Afrikaans vleitee

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000197707
Tropicos 13049569
KEW urn:lsid:ipni.org:names:489312-1
Open Tree Of Life 456904
NCBI Taxonomy 155109
IPNI 489312-1
iNaturalist 583180
GBIF 5341866
EPPO KCLSU
USDA GRIN 409485

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Editorial: Insights in ethnopharmacology: 2022 Kim CH, Heinrich M, Yen HR, Echeverria J, Lu A Front Pharmacol 29-Aug-2023
PMCID:PMC10497946
doi:10.3389/fphar.2023.1264063
PMID:37711171
Analysis of the Differentially Expressed Proteins and Metabolic Pathways of Honeybush (Cyclopia subternata) in Response to Water Deficit Stress Mahlare MJ, Husselmann L, Lewu MN, Bester C, Lewu FB, Caleb OJ Plants (Basel) 31-May-2023
PMCID:PMC10255181
doi:10.3390/plants12112181
PMID:37299160
Biocontrol of Fusarium Species Utilizing Indigenous Rooibos and Honeybush Extracts Omoruyi BE, Volschenk H, Gelderblom WC, Lilly M Microbiol Spectr 24-May-2023
PMCID:PMC10269529
doi:10.1128/spectrum.02742-22
PMID:37222581
Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist Olayoku FR, Verhoog NJ, Louw A Front Pharmacol 13-Mar-2023
PMCID:PMC10040842
doi:10.3389/fphar.2023.1122031
PMID:36992834
Natural flavonoids derived from herbal medicines are potential anti-atherogenic agents by inhibiting oxidative stress in endothelial cells Li RL, Wang LY, Duan HX, Qian D, Zhang Q, He LS, Li XP Front Pharmacol 24-Feb-2023
PMCID:PMC10001913
doi:10.3389/fphar.2023.1141180
PMID:36909175
Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach Norshidah H, Leow CH, Ezleen KE, Wahab HA, Vignesh R, Rasul A, Lai NS Front Cell Infect Microbiol 14-Feb-2023
PMCID:PMC9971573
doi:10.3389/fcimb.2023.1061937
PMID:36864886
Effect of Stress Signals and Ib-rolB/C Overexpression on Secondary Metabolite Biosynthesis in Cell Cultures of Ipomoea batatas Vasyutkina EA, Yugay YA, Grigorchuk VP, Grishchenko OV, Sorokina MR, Yaroshenko YL, Kudinova OD, Stepochkina VD, Bulgakov VP, Shkryl YN Int J Mol Sci 01-Dec-2022
PMCID:PMC9740395
doi:10.3390/ijms232315100
PMID:36499423
Combinatorial treatments of tamoxifen and SM6Met, an extract from Cyclopia subternata Vogel, are superior to either treatment alone in MCF-7 cells van Dyk L, Verhoog NJ, Louw A Front Pharmacol 22-Sep-2022
PMCID:PMC9535530
doi:10.3389/fphar.2022.1017690
PMID:36210845
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals Gómez-Garduño J, León-Rodríguez R, Alemón-Medina R, Pérez-Guillé BE, Soriano-Rosales RE, González-Ortiz A, Chávez-Pacheco JL, Solorio-López E, Fernandez-Pérez P, Rivera-Espinosa L Dose Response 21-Sep-2022
PMCID:PMC9500303
doi:10.1177/15593258221120485
PMID:36158743
Comparative Metabolomics Analysis of Stigmas and Petals in Chinese Saffron (Crocus sativus) by Widely Targeted Metabolomics Zhou L, Cai Y, Yang L, Zou Z, Zhu J, Zhang Y Plants (Basel) 17-Sep-2022
PMCID:PMC9502368
doi:10.3390/plants11182427
PMID:36145828
Anti-Inflammatory, Anti-Diabetic, Anti-Oxidant and Cytotoxicity Assays of South African Herbal Teas and Bush Tea Blends Malongane F, McGaw LJ, Olaokun OO, Mudau FN Foods 27-Jul-2022
PMCID:PMC9368003
doi:10.3390/foods11152233
PMID:35954001
Design of Functional Powdered Beverages Containing Co-Microcapsules of Sacha Inchi P. huayllabambana Oil and Antioxidant Extracts of Camu Camu and Mango Skins Chasquibol N, Alarcón R, Gonzales BF, Sotelo A, Landoni L, Gallardo G, García B, Pérez-Camino MC Antioxidants (Basel) 22-Jul-2022
PMCID:PMC9332271
doi:10.3390/antiox11081420
PMID:35892621
Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches Kumar V, Singh DD, Lakhawat SS, Yasmeen N, Pandey A, Singla RK Evid Based Complement Alternat Med 27-Mar-2022
PMCID:PMC8977300
doi:10.1155/2022/6852276
PMID:35388304
Modelling and targeting mitochondrial protein tyrosine phosphatase 1: a computational approach Ragunathan V, Chithra K, Shivanika C, Sudharsan MS In Silico Pharmacol 17-Jan-2022
PMCID:PMC8762535
doi:10.1007/s40203-022-00119-z
PMID:35111562
Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells Casado-Díaz A, Rodríguez-Ramos Á, Torrecillas-Baena B, Dorado G, Quesada-Gómez JM, Gálvez-Moreno MÁ Nutrients 22-Nov-2021
PMCID:PMC8623874
doi:10.3390/nu13114185
PMID:34836440

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lignans, neolignans and related compounds / Furanoid lignans / Tetrahydrofuran lignans / 7,9-epoxylignans
Lariciresinol dimethyl ether 14237703 Click to see COC1=C(C=C(C=C1)CC2COC(C2CO)C3=CC(=C(C=C3)OC)OC)OC 388.50 unknown https://doi.org/10.1021/JF040097Z
> Organic oxygen compounds / Organooxygen compounds / Alcohols and polyols / Cyclitols and derivatives / Shikimic acids and derivatves
(+)-Shikimic acid 10986763 Click to see C1C(C(C(C=C1C(=O)O)O)O)O 174.15 unknown https://doi.org/10.1021/JF040097Z
> Organoheterocyclic compounds / Benzopyrans / 1-benzopyrans / Xanthones
Mangiferin 5281647 Click to see C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O 422.30 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Cinnamic acids and derivatives / Hydroxycinnamic acids and derivatives / Hydroxycinnamic acids
4-Hydroxycinnamic acid 322 Click to see C1=CC(=CC=C1C=CC(=O)O)O 164.16 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Flavonoids / Flavans / Flavanones
5,7,2'-Trihydroxyflavanone 179999 Click to see C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3O 272.25 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Flavonoids / Flavones
Luteolin 5280445 Click to see C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O 286.24 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid C-glycosides
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one 56674291 Click to see C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C=C(C(=C3O)C4C(C(C(C(O4)CO)O)O)O)O)O)O 448.40 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides
2-[[2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-chromen-5-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol 73802641 Click to see C1CC2=C(C=C(C=C2OC3C(C(C(C(O3)CO)O)O)O)O)OC1C4=CC(=C(C=C4)O)O 436.40 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Flavonoids / Flavonoid glycosides / Flavonoid O-glycosides / Flavonoid-7-O-glycosides
[2-Acetyloxy-4-[5-hydroxy-4-oxo-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-2-yl]phenyl] acetate 162878067 Click to see CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC(=O)C)OC(=O)C)O)O)O)O)O)O)O 678.60 unknown https://doi.org/10.1021/JF040097Z
2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one 3564542 Click to see CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O)O 596.50 unknown https://doi.org/10.1021/JF040097Z
Narirutin 442431 Click to see CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)O)O)O)O)O)O 580.50 unknown https://doi.org/10.1021/JF040097Z
> Phenylpropanoids and polyketides / Isoflavonoids / Isoflav-2-enes / Isoflavones
Orobol 5281801 Click to see C1=CC(=C(C=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O)O 286.24 unknown https://doi.org/10.1021/JF040097Z

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