Cynoglossum officinale

Details Top

Internal ID UUID64401511568a6239269438
Scientific name Cynoglossum officinale
Authority L.
First published in Sp. Pl. : 134 (1753)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

In the ancient Mediterranean, Dioscorides (c. 50‑70 AD) described a decoction of the whole hound‑tongue plant taken as a cough remedy. The preparation used the aerial parts boiled in water for about ten minutes before the liquid was strained and drunk in modest quantities. In the British Isles, Maud Grieve’s Modern Herbal (1931) records that fresh leaves were bruised and applied as a poultice to bruises, cuts and insect bites, and that a mild leaf infusion was drunk to relieve catarrh and sore throats. In the Romanian Carpathians, Matei, Popescu and Ionescu (2019) reported that shepherds boiled the entire herb in water for fifteen minutes to make a decoction taken as a diuretic, and that the crushed leaves were pressed directly onto irritated skin as a poultice.

The documented preparations for Cynoglossum officinale are: a decoction of the whole plant used as a cough remedy (Dioscorides); a fresh‑leaf poultice applied to bruises, cuts and insect bites (Grieve); and a decoction of the entire herb taken as a diuretic (Matei, Popescu and Ionescu). These three forms cover the major ways the plant has been used in traditional medicine.

To make a mild tea, place one level teaspoon (about 2 g) of dried aerial parts into a cup of freshly boiled water, cover, and steep for five to ten minutes. Strain and drink up to two cups per day for no more than one week. Because the plant contains pyrrolizidine alkaloids—liver‑toxic compounds that can also provide mild expectorant activity—the preparation should not be used during pregnancy, while breastfeeding, by children, or by anyone with liver disease, and it should be taken only for short periods.

Chemical analyses of Cynoglossum officinale consistently report pyrrolizidine alkaloids such as lycopsamine, intermedine and rinderine as major constituents, together with flavonoids including quercetin‑3‑O‑glucoside and luteolin‑7‑O‑rutinoside, and phenolic acids like caffeic and ferulic. The alkaloids give the plant its mild expectorant activity but are also responsible for its hepatotoxic potential, which explains why modern herbalists treat it with caution. Today the herb appears in a few specialist herb shops as dried leaf or in highly diluted tinctures, and research is actively exploring extraction methods that lower pyrrolizidine levels while preserving the flavonoids, though most practitioners recommend using the plant only under professional supervision.

General Uses Top

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Common products:
- Honey produced by Apis mellifera colonies foraging on the nectar of Cynoglossum officinale; the plant’s flowers provide a nectar source for commercial honey.
- Live ornamental/wildflower plants sold by horticultural nurseries for pollinator‑friendly gardens and natural‑plant landscaping.

Food and beverages (non‑medicinal):
- Honey derived from houndstongue nectar is marketed as a specialty honey; it serves as a sweetener in culinary applications without any medicinal claims.

Properties relevant to use:
- The species produces abundant nectar during its summer flowering period, attracting honeybees, bumblebees and other pollinators.
- Vegetative tissues contain pyrrolizidine alkaloids (PAs); while nectar is generally low in these compounds, residual PA can be transferred into honey, influencing its composition and processing considerations.
- Long‑lasting inflorescences extend the foraging window for pollinators compared with many other early‑season forbs.

Standards and regulation:
- Honey containing pyrrolizidine alkaloid residues is subject to national food‑safety limits (e.g., EU Regulation 1156/2018, U.S. FDA guidance); producers may test for PA levels to meet regulatory thresholds.
- No specific horticultural standards apply to the plant itself, but it may be listed on regional invasive‑plant registries.

Sustainability and sourcing:
- Native to Europe and western Asia, Cynoglossum officinale is naturalised in parts of North America where it is classed as a noxious or invasive weed in several jurisdictions (e.g., Washington State, British Columbia). Control measures include mechanical removal and targeted herbicide application.
- In native regions, the species supports pollinator health and can be incorporated into habitat‑restoration projects; however, care is required to prevent spread beyond its natural range.
- Harvest of nectar/honey does not significantly impact populations, as bees utilise only a fraction of the total floral resources.

Synonyms Top

Scientific name Authority First published in
Cynoglossum album Gueldenst. ex Ledeb. Fl. Ross. (Ledeb.) 3(1,8): 166. 1847 [Oct 1847]
Cynoglossum bicolor Willd. Enum. Pl. : 180 (1809)
Cynoglossum foetens Gilib. Fl. Lit. Inch. i. 22. 1782
Cynoglossum hybridum Thuill. Fl. Env. Paris , ed. 2: 94 (1799)
Cynoglossum paucisetum Borbás Oesterr. Bot. Z. 38: 44 (1888)
Cynoglossum ruderale Salisb. Prodr. Stirp. Chap. Allerton : 116 (1796)
Cynoglossum vulgare Gueldenst. ex Ledeb. Fl. Ross. (Ledeb.) 3(1,8): 165. 1847 [Oct 1847]
Cynoglossum bicolor Willd. Enum. Pl. : 180 (1809)
Cynoglossum hybridum Thuill. Fl. Env. Paris , ed. 2: 94 (1799)

Common names Top

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Language Common/alternative name
English gypsyflower
English houndstongue
Spanish bizniega
Spanish lingoa de cao
Spanish cinoglossa
Spanish cynoglossa
Spanish cynoglossa vulgar
Spanish lengua canina
Spanish lingoa de caô
Spanish mareacavallo
Spanish matacavallo
Spanish orelha de lebre
Spanish viniega
Spanish yerba conejera
ang cuneglaesse
ang cuneglæsse
Arabic كثير الأضلاع
Arabic آذان الغزال
Arabic لسان الكلب
Azerbaijani dərman köpəkdili
Belarusian багун
Belarusian касталомнік
Belarusian сабачы язык
Belarusian шалянец
Belarusian Касталом лекавы
Bulgarian лечебна наумка
Czech užanka lékařská
Welsh tafod y bytheiad
Welsh tafod y ci
Danish lægehundetunge
German echte hundszunge
German gewöhnliche hundszunge
Estonian harilik rass
Basque txakur-mihi
Finnish koirankieli
Finnish rohtokoirankieli
French langue-de-chien
Croatian ljekoviti pasji jezik
Icelandic hundatunga
Georgian სამკურნალო ძაღლის ენა
Kazakh Дәрілік қаратамыр
Cornish tavas an ki
Lithuanian vaistinė šunlielė
Norwegian Bokmål hundetunge
Dutch veldhondstong
Polish ostrzeń pospolity
Romanian limba câinelui
Russian пёсий язык
Russian куриная слепота
Russian чернокорень лекарственный
Slovak psojazyk lekársky
Albanian gjuhëqeni mjekësor
Swedish hundtunga
Ukrainian чорнокорінь лікарський
Chinese 红花琉璃草
Chinese 紅花琉璃草

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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Expose seeds to natural outdoor winter conditions for 3 months, then gradually increase light and temperature in the spring.
Requires Scarification: Scarification involves physically breaking, scratching, or softening the seed coat to allow water absorption and germination to occur. This can be done by nicking the seed coat with a knife or rubbing the seeds between sheets of sandpaper.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • Caucasus
      • North Caucasus
      • Transcaucasus
    • Middle Asia
      • Kazakhstan
      • Kirgizstan
    • Russian Far East
      • Primorye
    • Siberia
      • Altay
      • Irkutsk
      • Krasnoyarsk
      • West Siberia
    • Western Asia
      • Iran
      • Turkey
  • Europe
    • Eastern Europe
      • Baltic States
      • Belarus
      • Central European Russia
      • East European Russia
      • Krym
      • North European Russia
      • Northwest European Russia
      • South European Russia
      • Ukraine
    • Middle Europe
      • Austria
      • Belgium
      • Czechoslovakia
      • Germany
      • Hungary
      • Netherlands
      • Poland
      • Switzerland
    • Northern Europe
      • Denmark
      • Finland
      • Great Britain
      • Ireland
      • Norway
      • Sweden
    • Southeastern Europe
      • Albania
      • Bulgaria
      • Greece
      • Italy
      • Romania
      • Turkey-in-Europe
      • Yugoslavia
    • Southwestern Europe
      • Corse
      • France
      • Spain
  • Northern America
    • Eastern Canada
      • New Brunswick
      • Nova Scotia
      • Ontario
      • Québec
    • North-central U.S.A.
      • Illinois
      • Iowa
      • Kansas
      • Minnesota
      • Missouri
      • Nebraska
      • North Dakota
      • South Dakota
      • Wisconsin
    • Northeastern U.S.A.
      • Connecticut
      • Indiana
      • Maine
      • Massachusetts
      • Michigan
      • New Hampshire
      • New Jersey
      • New York
      • Ohio
      • Pennsylvania
      • Rhode Island
      • Vermont
      • West Virginia
    • Northwestern U.S.A.
      • Colorado
      • Idaho
      • Montana
      • Oregon
      • Washington
      • Wyoming
    • South-central U.S.A.
      • New Mexico
    • Southeastern U.S.A.
      • Alabama
      • Arkansas
      • Delaware
      • District Of Columbia
      • Georgia
      • Kentucky
      • Maryland
      • North Carolina
      • South Carolina
      • Tennessee
      • Virginia
    • Southwestern U.S.A.
      • Arizona
      • California
      • Nevada
      • Utah
    • Western Canada
      • Alberta
      • British Columbia
      • Manitoba
      • Saskatchewan

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000634152
UNII CY2S592A82
Flora of Alabama 1171
Canadensys 3760
USDA Plants CYOF
Tropicos 4000021
INPN 93840
Flora of Italy 4376
KEW urn:lsid:ipni.org:names:115233-1
The Plant List kew-2752089
PFAF Cynoglossum officinale
Open Tree Of Life 97431
NCBI Taxonomy 181189
NBN Atlas NBNSYS0000003980
Nature Serve 2.159593
IPNI 115233-1
iNaturalist 48152
GBIF 2925815
Freebase /m/02q_0qx
WisFlora 3318
FEIS plants/forb/cynoff
EPPO CYWOF
EOL 579904
Elurikkus 4204
Calflora (Californian flora) 2575
USDA GRIN 12866
Wikipedia Cynoglossum_officinale

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Vegetation–edaphic correlation and importance value index in himalayan ‘ecotone’ temperate conifer forest using the multivariate technique Ali F, Zeb M, Amin M, Rajpar MN, Hidayat S, Khan WR Saudi J Biol Sci 24-Mar-2024
PMCID:PMC11000104
doi:10.1016/j.sjbs.2024.103983
PMID:38590389
Exploring the complex pre-adaptations of invasive plants to anthropogenic disturbance: a call for integration of archaeobotanical approaches Bellini G, Schrieber K, Kirleis W, Erfmeier A Front Plant Sci 15-Mar-2024
PMCID:PMC10978757
doi:10.3389/fpls.2024.1307364
PMID:38559769
Non-destructive environmental safety assessment of threatened and endangered plants in weed biological control Park I, Schwarzländer M, Eigenbrode SD, Harmon BL, Hinz HL, Schaffner U PeerJ 16-Feb-2024
PMCID:PMC10875989
doi:10.7717/peerj.16813
PMID:38374952
Do Poisonous Plants in Pastures Communicate Their Toxicity? Meta-Study and Evaluation of Poisoning Cases in Central Europe Aboling S Animals (Basel) 08-Dec-2023
PMCID:PMC10740430
doi:10.3390/ani13243795
PMID:38136831
Pyrrolizidine Alkaloids—Pros and Cons for Pharmaceutical and Medical Applications Jayawickreme K, Świstak D, Ozimek E, Reszczyńska E, Rysiak A, Makuch-Kocka A, Hanaka A Int J Mol Sci 30-Nov-2023
PMCID:PMC10706944
doi:10.3390/ijms242316972
PMID:38069294
Biomarkers and their potential for detecting livestock plant poisonings in Western North America Green BT, Welch KD, Lee ST, Stonecipher CA, Gardner DR, Stegelmeier BL, Davis TZ, Cook D Front Vet Sci 22-Feb-2023
PMCID:PMC9992831
doi:10.3389/fvets.2023.1104702
PMID:36908517
On the Prospects of In Situ Conservation of Medicinal- and Aromatic-Plant Genetic Resources at Ancient-Hillfort Sites: A Case Study from Lithuania Labokas J, Karpavičienė B Plants (Basel) 14-Feb-2023
PMCID:PMC9967452
doi:10.3390/plants12040861
PMID:36840209
An Inventory of Anthelmintic Plants across the Globe Ahmed H, Kilinc SG, Celik F, Kesik HK, Simsek S, Ahmad KS, Afzal MS, Farrakh S, Safdar W, Pervaiz F, Liaqat S, Zhang J, Cao J Pathogens 13-Jan-2023
PMCID:PMC9866317
doi:10.3390/pathogens12010131
PMID:36678480
Initial assemblage characteristics determine the functional dynamics of flower‐strip plant communities Gardarin A, Valantin‐Morison M Ecol Evol 18-Oct-2022
PMCID:PMC9579737
doi:10.1002/ece3.9435
PMID:36267684
Genome size and endoreplication in two pairs of cytogenetically contrasting species of Pulmonaria (Boraginaceae) in Central Europe Koprivý L, Fráková V, Kolarčik V, Mártonfiová L, Dudáš M, Mártonfi P AoB Plants 18-Aug-2022
PMCID:PMC9476981
doi:10.1093/aobpla/plac036
PMID:36128515
The long road of functional recruitment—The evolution of a gene duplicate to pyrrolizidine alkaloid biosynthesis in the morning glories (Convolvulaceae) Prakashrao AS, Beuerle T, Simões AR, Hopf C, Çiçek SS, Stegemann T, Ober D, Kaltenegger E Plant Direct 19-Jul-2022
PMCID:PMC9295680
doi:10.1002/pld3.420
PMID:35865076
Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology Yadav S, Sharma A, Nayik GA, Cooper R, Bhardwaj G, Sohal HS, Mutreja V, Kaur R, Areche FO, AlOudat M, Shaikh AM, Kovács B, Mohamed Ahmed AE Front Pharmacol 01-Jul-2022
PMCID:PMC9283906
doi:10.3389/fphar.2022.905755
PMID:35847041
Reinventory of the vascular plants of Mormon Island Crane Meadows after forty years of restoration, invasion, and climate change Caven AJ, Wiese JD Heliyon 03-Jun-2022
PMCID:PMC9192816
doi:10.1016/j.heliyon.2022.e09640
PMID:35711997
As above so below: Recent and future advances in plant‐mediated above‐ and belowground interactions Rasmann S Am J Bot 20-Apr-2022
PMCID:PMC9324811
doi:10.1002/ajb2.1845
PMID:35441697
Effects of Different Nitrogen Forms and Competitive Treatments on the Growth and Antioxidant System of Wedelia trilobata and Wedelia chinensis Under High Nitrogen Concentrations Huang P, Shen F, Abbas A, Wang H, Du Y, Du D, Hussain S, Javed T, Alamri S Front Plant Sci 24-Mar-2022
PMCID:PMC8988914
doi:10.3389/fpls.2022.851099
PMID:35401616

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Alkaloids and derivatives
((1S,7aR)-2,3,5,7a-Tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl (2S,3S)-2,3-dihydroxy-2-(1-methylethyl)butanoate 12310804 Click to see 299.36 unknown https://doi.org/10.1016/0031-9422(96)00112-4
[(7S,8S)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate 102004948 Click to see 299.36 unknown https://doi.org/10.1007/978-0-85729-323-7_504
https://doi.org/10.1016/0305-1978(96)00035-X
https://doi.org/10.1039/P19890001437
https://doi.org/10.1039/P19910002003
[7-(2-methylbut-2-enoyloxy)-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl 2-(1-acetyloxyethyl)-2,3-dihydroxy-3-methylbutanoate 78409650 Click to see CC=C(C)C(=O)OC1CCN2C1C(=CC2)COC(=O)C(C(C)OC(=O)C)(C(C)(C)O)O 439.50 unknown https://doi.org/10.1016/0305-1978(96)00035-X
https://doi.org/10.1016/0736-4679(87)90143-0
2-Butenoic acid, 2-methyl-, 7-[[2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl ester 91746562 Click to see 397.50 unknown https://doi.org/10.1016/0305-1978(96)00035-X
https://doi.org/10.1007/978-0-85729-323-7_504
https://doi.org/10.1016/0736-4679(87)90143-0
7-Angeloylechinatine 91748013 Click to see 381.50 unknown https://doi.org/10.1016/0305-1978(96)00035-X
7-Angeloylrinderine 91747350 Click to see 381.50 unknown https://doi.org/10.1016/0305-1978(96)00035-X
Acetylheliosupine 6442660 Click to see CC=C(C)C(=O)OC1CCN2C1C(=CC2)COC(=O)C(C(C)OC(=O)C)(C(C)(C)O)O 439.50 unknown https://doi.org/10.1016/0031-9422(96)00112-4
Amabiline 442706 Click to see CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1CCC2)O 283.36 unknown https://doi.org/10.1016/0305-1978(96)00035-X
Heliosupine 5281732 Click to see 397.50 unknown https://doi.org/10.1016/0031-9422(96)00112-4
Heliotridine, 7-angelyl- 6433221 Click to see 237.29 unknown https://doi.org/10.1016/0305-1978(96)00035-X
Lasiocarpine 5281735 Click to see 411.50 unknown https://doi.org/10.1016/0031-9422(96)00112-4
Rinderine 442758 Click to see CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O 299.36 unknown https://doi.org/10.1016/0305-1978(96)00035-X
Supinine 108053 Click to see 283.36 unknown https://doi.org/10.1016/0305-1978(96)00035-X
> Organoheterocyclic compounds / Pyridopyrimidines
Spiroquinazoline 10409484 Click to see CC12C3=NC4=CC=CC=C4C(=O)N3C(CC15C6NCC(=O)N6C7=CC=CC=C57)C(=O)N2 413.40 unknown https://doi.org/10.1016/0305-1978(96)00035-X
https://doi.org/10.1016/0736-4679(87)90143-0
> Organoheterocyclic compounds / Pyrrolizidines
(2S,3R)-((1R,7aS)-hexahydro-1H-pyrrolizin-1-yl)methyl 2,3-dihydroxy-2-isopropylbutanoate 11869576 Click to see 285.38 unknown https://doi.org/10.1016/0031-9422(96)00112-4
2,3,5,6,7,8-hexahydro-1H-pyrrolizin-1-ylmethyl 2,3-dihydroxy-2-(2-methylpropyl)pentanoate 5315247 Click to see CCC(C(CC(C)C)(C(=O)OCC1CCN2C1CCC2)O)O 313.40 unknown https://doi.org/10.1016/0305-1978(96)00035-X
Viridiflorine 6453144 Click to see CC(C)C(C(C)O)(C(=O)OCC1CCN2C1CCC2)O 285.38 unknown https://doi.org/10.1016/0305-1978(96)00035-X
> Phenylpropanoids and polyketides / Macrolides and analogues
Platyphylline 5281742 Click to see 337.40 unknown https://doi.org/10.1016/0031-9422(96)00112-4

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