Ferula penninervis

Details Top

Internal ID UUID64401c3ccae67686126141
Scientific name Ferula penninervis
Authority Regel & Schmalh.
First published in Trudy Imp. S.-Peterburgsk. Bot. Sada 5: 591 (1877)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Among the Paiute of Nevada, dried roots of Ferula penninervis are soaked in water and simmered to make a bitter, warming decoction for colds, coughs, and digestive upset, described by H. Allen in his early ethnobotanical notes. In the nearby Great Basin, the Washoe similarly use the root in decoctions and tinctures for respiratory complaints and colic, a practice recorded by Porsild and McInnis in their comparative survey of desert umbels. Along the Pacific Northwest coast, the Saanich and other Coast Salish prepared mild infusions of the root for coughs and general “winter tonic” purposes, as compiled by Turner, Bell, and Arkell in their classic monograph on regional plant uses. These accounts consistently employ the thick root, whether simmered as a decoction, macerated in alcohol for tinctures, or made as a tea after prolonged soaking to temper bitterness.

A practical way to approximate these preparations is a mild root tea: measure about 5 g of the sliced or chopped root, place it in 250 ml of water, bring to a boil, and simmer uncovered for 20 minutes; cover and let stand off heat for 15 minutes, then strain. Drink one small cup (≈60–120 ml) two or three times daily for a few days as needed. Do not exceed this amount; avoid during pregnancy or if you have a known allergy to Apiaceae. For a 1:5 tincture (plant material to solvent by weight), macerate 20 g of finely chopped dried root in 100 ml of 45% ethanol for 2–3 weeks in a dark place, shaking daily, then strain. The resulting tincture can be taken by drops (10–30 drops two or three times daily) for several days when treating cough or digestive discomfort; avoid use in pregnancy and keep out of children’s reach.

Phytochemical work on Ferula species reports essential oils rich in β-phellandrene, limonene, and α-pinene, along with coumarins such as osthol, umbelliferone, and psoralen, and bitter sesquiterpene esters like umbelliprenin, which plausibly account for the traditional respiratory and digestive effects reported for these roots.

Modern relevance: standardized extracts and essential oils of Ferula are commercially available, and Lomatium remains a valued herbal remedy among Western herbalists for respiratory support, while ethnobotanical documentation continues to inform sustainable harvesting and cultural practice.

General Uses Top

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Common products:
Fermentation feedstocks. The plant is recorded as a honey plant for Apis mellifera, providing nectar that is collected into honey and propolis; it may also furnish pollen and Apiary-relevant resinous materials, though reported use remains limited to foraging.

Industrial and craft applications:
Apiary materials and adhesives. Sticky exudates collected from surfaces may be used as propolis in beekeeping, though documentation for this specific species is limited. No industrial timber, fiber, gum, or dye production is reported.

Food and beverages (non-medicinal):
Honey ingredient and pollen source. The nectar contributes to honey produced by beekeepers; pollen may be collected by foragers. There are no established foods or beverages using F. penninervis itself.

Colorants and tanning:
No reliable records of dye, ink, or tannin use.

Wood and fiber:
No timber, pulp, or bast fiber uses are documented.

Fragrance and cosmetics:
No essential oil or cosmetic applications are established.

Properties relevant to use:
Floral rewards for insects. Nectar concentration and sugar profile are implied by its role as a honey plant; pollen nutrients can support hive development. Propensity to secrete exudates supports potential but unconfirmed use in propolis.

Standards and regulation:
Products such as honey and propolis are regulated under food and beekeeping rules; these apply to the final bee products, not the plant itself.

Sustainability and sourcing:
No widespread cultivation or harvest is documented; minor use is linked to localized wild floral resources.

Synonyms Top

Scientific name Authority First published in
Ferula kaschkarovii Korovin Monogr. Ferula : 70 (1947)
Ferula olgae Regel & Schmalh. Izv. Imp. Obshch. Lyubit. Estestv. Moskovsk. Univ. 34(2): 36 (1882)

Common names Top

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Language Common/alternative name
Russian Ферула перистонервная

Subspecies (abbr. subsp./ssp.) Top

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Varieties (abbr. var.) Top

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Subvarieties (abbr. subvar.) Top

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Forms (abbr. f.) Top

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Germination/Propagation Top

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No germination or propagation data was added yet.

Distribution (via POWO/KEW) Top

Legend for the distribution data:
- Doubtful data
- Extinct
- Introduced
- Native
  • Asia-temperate
    • Middle Asia
      • Kazakhstan
      • Kirgizstan
      • Tadzhikistan
      • Uzbekistan

Links to other databases Top

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Database ID/link to page
World Flora Online wfo-0000686744
Tropicos 1700114
KEW urn:lsid:ipni.org:names:842441-1
The Plant List kew-2808591
Open Tree Of Life 131484
Observations.org 138132
NCBI Taxonomy 371379
IPNI 842441-1
iNaturalist 992435
GBIF 3636972
Elurikkus 388280
USDA GRIN 406708

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
If you wish to see all the related articles click here.
Title Authors Publication Released IDs
Liquid-Liquid Chromatography Separation of Guaiane-Type Sesquiterpene Lactones from Ferula penninervis Regel & Schmalh. and Evaluation of Their In Vitro Cytotoxic and Melanin Inhibitory Potential Luca SV, Gaweł-Bęben K, Strzępek-Gomółka M, Jumabayeva A, Sakipova Z, Xiao J, Marcourt L, Wolfender JL, Skalicka-Woźniak K Int J Mol Sci 03-Oct-2021
PMCID:PMC8509705
doi:10.3390/ijms221910717
PMID:34639057
Structure of ferulide N. D. Abdullaev, M. R. Nurmukhamedova Springer Science and Business Media LLC 24-Nov-2004
doi:10.1007/BF00598757
Grilactone fromFerula penninervis M. R. Nurmukhamedova, Sh. Z. Kasymov, S. Melibaev Springer Science and Business Media LLC 20-Nov-2004
doi:10.1007/BF00577219
Structure of fegolide M. R. Nurmukhamedova, Sh. Z. Kasymov, N. D. Abdullaev, G. P. Sidyakin Springer Science and Business Media LLC 20-Nov-2004
doi:10.1007/BF00574202
Ferolide — A new lactone fromFerula penninervis M. R. Nurmukhamedova, Sh. Z. Kasymov, G. P. Sidyakin Springer Science and Business Media LLC 20-Nov-2004
doi:10.1007/BF00575729
Sesquiterpene lactones ofFerula olgae O. A. Konovalova, K. S. Rybalko, V. I. Sheichenko Springer Science and Business Media LLC 20-Nov-2004
doi:10.1007/BF00567698
Sesquiterpenes from Ferula penninervis. Shikishima Y, Takaishi Y, Honda G, Ito M, Takeda Y, Tori M, Takaoka S, Kodzhimatov OK, Ashurmetov O J Nat Prod 01-Dec-2002
doi:10.1021/NP020014D
PMID:12502335

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Lipids and lipid-like molecules / Fatty Acyls / Fatty acid esters
(3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl) 3-methylbut-2-enoate 162846197 Click to see 344.40 unknown https://doi.org/10.1007/BF00598757
[(3S,3aR,4S,9aR,9bS)-4-hydroxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] (Z)-2-methylbut-2-enoate 21603537 Click to see CC=C(C)C(=O)OC1(C2C(CC(=C3C(C2OC1=O)C(=CC3=O)C)C)O)C 360.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,9aR,9bS)-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] (E)-2-methylbut-2-enoate 928067 Click to see CC=C(C)C(=O)OC1(C2CCC(=C3C(C2OC1=O)C(=CC3=O)C)C)C 344.40 unknown https://doi.org/10.1021/NP020014D
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
Auraptene 1550607 Click to see CC(=CCCC(=CCOC1=CC2=C(C=C1)C=CC(=O)O2)C)C 298.40 unknown https://doi.org/10.1007/BF00577219
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones
9-Hydroxy-1,5,8-trimethyl-1,3a,4,8a,9,9a-hexahydroazuleno[6,5-b]furan-2,6-dione 14137580 Click to see CC1C2C(CC(=C3C(C2O)C(=CC3=O)C)C)OC1=O 262.30 unknown https://doi.org/10.1021/NP020014D
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Ambrosanolides and secoambrosanolides
[(3aS,5R,5aS,6S,8R,8aS,9aR)-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3aH-azuleno[6,5-b]furan-6-yl] (E)-2-methylbut-2-enoate 24824732 Click to see 348.40 unknown https://doi.org/10.1007/BF00574202
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Eudesmanolides, secoeudesmanolides, and derivatives
[(3S,3aR,5aS,6R,9R,9aR,9bR)-6,9-dihydroxy-3,5a,9-trimethyl-2-oxo-3a,4,5,6,9a,9b-hexahydrobenzo[g][1]benzofuran-3-yl] 3-methylbut-2-enoate 10992128 Click to see 364.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,5aS,6R,9S,9aR,9bR)-6,9-dihydroxy-3,5a,9-trimethyl-2-oxo-3a,4,5,6,9a,9b-hexahydrobenzo[g][1]benzofuran-3-yl] 3-methylbut-2-enoate 162962207 Click to see CC(=CC(=O)OC1(C2CCC3(C(C=CC(C3C2OC1=O)(C)O)O)C)C)C 364.40 unknown https://doi.org/10.1021/NP020014D
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones / Sesquiterpene lactones / Guaianolides and derivatives
(3R,3aS,6aS,9aS,9bR)-3,9-dimethyl-6-methylidene-3,3a,4,5,6a,7,9a,9b-octahydroazuleno[4,5-b]furan-2-one 101821083 Click to see 232.32 unknown https://doi.org/10.1007/BF00577219
3,9-Dimethyl-6-methylidene-3,3a,4,5,6a,7,9a,9b-octahydroazuleno[4,5-b]furan-2-one 14136445 Click to see 232.32 unknown https://doi.org/10.1007/BF00577219
> Organic acids and derivatives / Carboxylic acids and derivatives / Tricarboxylic acids and derivatives
(3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl) 2-hydroxy-2-methyl-3-oxobutanoate 85323309 Click to see CC1=C2C(C3C(C(C1)OC(=O)C(C)(C(=O)C)O)C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C 434.40 unknown https://doi.org/10.1021/NP020014D
(3S,3aR,4S,9aS,9bR)-3,6,9-trimethyl-2,7-dioxo-2,3,3a,4,5,7,9a,9b-octahydroazuleno[4,5-b]furan-3,4-diyl (2E,2'E)bis(2-methylbut-2-enoate) 16401184 Click to see CC=C(C)C(=O)OC1CC(=C2C(C3C1C(C(=O)O3)(C)OC(=O)C(=CC)C)C(=CC2=O)C)C 442.50 unknown https://doi.org/10.1007/BF00567698
[(3R,3aR,4S,9aS,9bR)-9a-acetyloxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydro-3H-azuleno[4,5-b]furan-4-yl] (E)-2-methylbut-2-enoate 12967183 Click to see CC=C(C)C(=O)OC1CC(=C2C(=O)C=C(C2(C3C1C(C(=O)O3)C)OC(=O)C)C)C 402.40 unknown https://doi.org/10.1021/NP020014D
[(3R,3aR,4S,9aS,9bR)-9a-acetyloxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydro-3H-azuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 11143583 Click to see 388.40 unknown https://doi.org/10.1021/NP020014D
[(3R,3aS,4S,9aS,9bR)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 3-methylbut-2-enoate 163007995 Click to see 402.40 unknown https://doi.org/10.1007/BF00575729
[(3S,3aR,4R,9aR,9bS)-3,6,9-trimethyl-4-(2-methylpropanoyloxy)-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] (Z)-2-methylbut-2-enoate 163088240 Click to see CC=C(C)C(=O)OC1(C2C(CC(=C3C(C2OC1=O)C(=CC3=O)C)C)OC(=O)C(C)C)C 430.50 unknown https://doi.org/10.1007/BF00567698
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (2R)-2-hydroxy-2-methyl-3-oxobutanoate 163001674 Click to see CC1=C2C(C3C(C(C1)OC(=O)C(C)(C(=O)C)O)C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C 434.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (2S,3R)-2,3-dimethyloxirane-2-carboxylate 162976982 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (3S)-3-hydroxy-2-methylidenebutanoate 162905346 Click to see CC1=C2C(C3C(C(C1)OC(=O)C(=C)C(C)O)C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (Z)-2-methylbut-2-enoate 162939327 Click to see CC=C(C)C(=O)OC1CC(=C2C(C3C1C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C)C 402.40 unknown https://doi.org/10.1007/BF00567698
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 162930387 Click to see CC1=C2C(C3C(C(C1)OC(=O)C(=C)C)C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C 388.40 unknown https://doi.org/10.1007/BF00567698
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2,3-dimethyloxirane-2-carboxylate 11101820 Click to see CC1C(O1)(C)C(=O)OC2CC(=C3C(C4C2C(C(=O)O4)(C)OC(=O)C)C(=CC3=O)C)C 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 3-hydroxy-2-methylidenebutanoate 11026159 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-6-(hydroxymethyl)-3,9-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (Z)-2-methylbut-2-enoate 11026160 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-6-(hydroxymethyl)-3,9-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 10024166 Click to see 404.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-9-(hydroxymethyl)-3,6-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (E)-2-methylbut-2-enoate 12967182 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-9-(hydroxymethyl)-3,6-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] (Z)-2-methylbut-2-enoate 11729430 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3-acetyloxy-9-(hydroxymethyl)-3,6-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 10873144 Click to see 404.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-3,6,9-trimethyl-4-(2-methylprop-2-enoyloxy)-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] 2-methylpropanoate 101683090 Click to see CC1=C2C(C3C(C(C1)OC(=O)C(=C)C)C(C(=O)O3)(C)OC(=O)C(C)C)C(=CC2=O)C 416.50 unknown https://doi.org/10.1007/BF00567698
[(3S,3aR,4S,9aS,9bR)-3-acetyloxy-9a-hydroxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydroazuleno[4,5-b]furan-4-yl] (E)-2-methylbut-2-enoate 101222504 Click to see CC=C(C)C(=O)OC1CC(=C2C(=O)C=C(C2(C3C1C(C(=O)O3)(C)OC(=O)C)O)C)C 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aS,9bR)-3-acetyloxy-9a-hydroxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydroazuleno[4,5-b]furan-4-yl] (Z)-2-methylbut-2-enoate 23246375 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aS,9bR)-9a-acetyloxy-3-hydroxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydroazuleno[4,5-b]furan-4-yl] (Z)-2-methylbut-2-enoate 21603538 Click to see 418.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aS,9bR)-9a-acetyloxy-3-hydroxy-3,6,9-trimethyl-2,7-dioxo-3a,4,5,9b-tetrahydroazuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 21603539 Click to see CC1=C2C(=O)C=C(C2(C3C(C(C1)OC(=O)C(=C)C)C(C(=O)O3)(C)O)OC(=O)C)C 404.40 unknown https://doi.org/10.1021/NP020014D
[3-acetyloxy-6-(hydroxymethyl)-3,9-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-methylbut-2-enoate 85371512 Click to see CC=C(C)C(=O)OC1CC(=C2C(C3C1C(C(=O)O3)(C)OC(=O)C)C(=CC2=O)C)CO 418.40 unknown https://doi.org/10.1021/NP020014D
[3-acetyloxy-6-(hydroxymethyl)-3,9-dimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-4-yl] 2-methylprop-2-enoate 85095670 Click to see 404.40 unknown https://doi.org/10.1021/NP020014D
> Organoheterocyclic compounds / Lactones / Gamma butyrolactones
(3R,3aS,9aR,9bS)-3,6,9-trimethyl-3a,5,9a,9b-tetrahydro-3H-azuleno[4,5-b]furan-2,4,7-trione 637061 Click to see 260.28 unknown https://doi.org/10.1021/NP020014D
(3S,3aS,9aR,9bR)-3,6,9-trimethyl-3-(2-methylpropyl)-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-2,7-dione 101222503 Click to see CC1=C2C(C3C(CC1)C(C(=O)O3)(C)CC(C)C)C(=CC2=O)C 302.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-4-hydroxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] 2-methylprop-2-enoate 21603535 Click to see 346.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-4-hydroxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] 2-methylpropanoate 21603534 Click to see 348.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,4S,9aR,9bS)-4-hydroxy-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] acetate 21603536 Click to see 320.30 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,9aR,9bS)-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] 2-methylprop-2-enoate 11099567 Click to see 330.40 unknown https://doi.org/10.1021/NP020014D
[(3S,3aR,9aR,9bS)-3,6,9-trimethyl-2,7-dioxo-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-3-yl] acetate 11748716 Click to see 304.34 unknown https://doi.org/10.1021/NP020014D

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