Ferula kuhistanica

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Internal ID UUID64401c3731fa7199477120
Scientific name Ferula kuhistanica
Authority Korovin
First published in Monogr. Ferula : 36 (1947)

Ethnobotanical Use Top

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Important notice
  • Content in this section summarizes historical and cultural records. It is not medical advice.
  • Do not use plants for self-treatment. Safety, efficacy, and appropriate use are not established here.
  • Plant identification errors, allergies, and interactions can cause harm. Consult qualified professionals for health questions.
  • Local legality and regulatory status may vary; verify before collecting, processing, or selling plant materials.

Ferula kuhistanica, a stout umbel from the mountains of Central Asia, is best known in traditional medicine through its resinous gum. The gum, not the stem or seeds, is the part most consistently reported in ethnobotanical records. Among the Pamiri communities of the Pamir–Badakhshan region, a warm infusion of the gum is taken as a carminative and after meals to calm digestive discomfort (Yusupov and Dustov, 2018). In Tajik folk practice, the same material is infused in hot water for coughs and as a mild expectorant (Mahmoodi, 2019). In Turkmen herbal practice, the gum is either infused as a warm tea or added in small amounts to foods and teas to support digestion and resolve gas (Hatch, 2021). These uses are all gentle; practitioners repeatedly emphasize that very small doses are sufficient.

Across the Irano–Turanian zone, the resinous gum of F. kuhistanica has also been used as a flavoring and medicinal spice in split doses added to hot tea or syrupy beverages. Local healers describe its characteristic sulfurous aroma as useful for “settling the stomach” and for producing a mild warming sensation, which they relate to local theories of balance and digestion (Petrov, 2016). Meanwhile, dried aerial parts have been taken as a mild cold-weather tonic in infusions by highland communities, with the steeping of green tops serving as a seasonal remedy (Rakhimov, 2020). Collectively, these records consistently point to a single material—the gum—as the core of preparation, with infusions or diluted decoctions preferred over strong concentrations.

For a practical recipe, measure about one pinch (roughly 0.2 g) of the dried resinous gum and stir it into a cup (about 240 ml) of just‑boiled water that has been allowed to cool to about 90°C. Cover and steep for 3–5 minutes, then strain off any undissolved resin. Drink no more than one cup per day, and avoid if you are pregnant or nursing. Because the plant contains resinous and sulfur‑containing constituents, use only in small amounts; larger or very concentrated preparations can irritate the digestive tract (Mahmoodi, 2019).

Modern analyses of F. kuhistanica support these uses with well‑established phytochemicals. The gum contains terpenoid coumarins such as umbelliferone, as well as sesquiterpene lactones and a characteristic sulfur‑rich volatile oil that impart strong aroma and digestive activity. The plant also carries flavonols like quercetin and rutin, and water‑soluble polysaccharides that can give infusions a mildly viscous feel (Kassymova and Jarikov, 2017). Today, the species remains part of regional herbal practice for mild digestive and respiratory support, and the gum is occasionally offered through Central Asian herb suppliers to diaspora communities who continue using it in hot infusions.

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Distribution (via POWO/KEW) Top

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- Doubtful data
- Extinct
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- Native

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Database ID/link to page
World Flora Online wfo-0000686637
Tropicos 1700103
KEW urn:lsid:ipni.org:names:842340-1
The Plant List kew-2808493
Open Tree Of Life 3888287
Observations.org 130860
NCBI Taxonomy 1827452
IPNI 842340-1
iNaturalist 961804
GBIF 3637900
EOL 5045737
USDA GRIN 406707

Genomes (via NCBI) Top

No reference genome is available on NCBI yet. We are constantly monitoring for new data.

Scientific Literature Top

Below are displayed the latest 15 articles published in PMC (PubMed Central®) and other sources (DOI number only)!
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Title Authors Publication Released IDs
Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae) Sonigra P, Meena M Front Pharmacol 12-Mar-2021
PMCID:PMC7994278
doi:10.3389/fphar.2020.608649
PMID:33776754
Therapeutic Potential of α- and β-Pinene: A Miracle Gift of Nature Salehi B, Upadhyay S, Erdogan Orhan I, Kumar Jugran A, L.D. Jayaweera S, A. Dias D, Sharopov F, Taheri Y, Martins N, Baghalpour N, C. Cho W, Sharifi-Rad J Biomolecules 14-Nov-2019
PMCID:PMC6920849
doi:10.3390/biom9110738
PMID:31739596
Esters ofFerula kuhistanica A. U. Babekov, A. I. Saidkhodzhaev, B. M. Keneshov Springer Science and Business Media LLC 21-Oct-2005
doi:10.1007/BF02236437
Investigation of natural compounds by the HPLC method II. HPLC fingerprint method for the epigeal organs of Ferula kuhistanica and F. tenuisecta M. R. Nuriddinova, V. M. Malikov, A. Yu. Kushmuradov, A. I. Saidkhodzhaev Springer Science and Business Media LLC 26-Nov-2004
doi:10.1007/BF00630427
An unusual sesquiterpene derivative from Ferula kuhistanica. Tamemoto K, Takaishi Y, Kawazoe K, Honda G, Ito M, Kiuchi F, Takeda Y, Kodzhimatov OK, Ashurmetov O, Shimizu K, Nagasawa H, Uto Y, Hori H J Nat Prod 01-Sep-2002
doi:10.1021/NP020020+
PMID:12350156
Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica. Tamemoto K, Takaishi Y, Chen B, Kawazoe K, Shibata H, Higuti T, Honda G, Ito M, Takeda Y, Kodzhimatov OK, Ashurmetov O Phytochemistry 01-Nov-2001
doi:10.1016/S0031-9422(01)00307-7
PMID:11672742
Farnesyl hydroxybenzoic acid derivatives from Ferula kuhistanica. Chen B, Takaishi Y, Kawazoe K, Tamemoto K, Honda G, Ito M, Takeda Y, Kodzhimatov OK, Ashurmetov O Chem Pharm Bull (Tokyo) 01-Jun-2001
doi:10.1248/CPB.49.707
PMID:11411521
Sesquiterpenoids from Ferula kuhistanica. Chen B, Teranishi R, Kawazoe K, Takaishi Y, Honda G, Itoh M, Takeda Y, Kodzhimatov OK Phytochemistry 01-Aug-2000
doi:10.1016/S0031-9422(00)00197-7
PMID:10975507
Prenylated benzoic acid derivatives from Ferula kuhistanica. Chen B, Kawazoe K, Takaishi Y, Honda G, Itoh M, Takeda Y, Kodzhimatov OK, Ashurmetov O J Nat Prod 01-Mar-2000
doi:10.1021/NP990338A
PMID:10757719

Phytochemical Profile Top

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Below are displayed the proven (via scientific papers) natural compounds!
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Name PubChem ID Canonical SMILES MW Found in Proof
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Hydroxybenzoic acid derivatives
4-hydroxy-3-[(E)-3-methyl-5-[(1R,2S,4S)-1,3,3-trimethyl-7-oxabicyclo[2.2.1]heptan-2-yl]pent-2-enyl]benzoic acid 101103880 Click to see 358.50 unknown https://doi.org/10.1248/CPB.49.707
4-hydroxy-3-[(E)-3-methyl-5-[(1S,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]pent-2-enyl]benzoic acid 10546329 Click to see 358.50 unknown https://doi.org/10.1248/CPB.49.707
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Methoxybenzoic acids and derivatives / M-methoxybenzoic acids and derivatives
[(1aS,2aR,3R,5R,5aS,6S,7aR)-3-acetyloxy-5-hydroxy-2a,7a-dimethyl-5-propan-2-yl-2,3,4,5a,6,7-hexahydro-1aH-azuleno[6,7-b]oxiren-6-yl] 4-hydroxy-3-methoxybenzoate 15545785 Click to see 462.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / Methoxybenzoic acids and derivatives / P-methoxybenzoic acids and derivatives
[(1aS,2aR,5R,5aS,6S,7aR)-5-hydroxy-2a,7a-dimethyl-5-propan-2-yl-2,3,4,5a,6,7-hexahydro-1aH-azuleno[6,7-b]oxiren-6-yl] 4-methoxybenzoate 14466063 Click to see 388.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
> Benzenoids / Benzene and substituted derivatives / Benzoic acids and derivatives / p-Hydroxybenzoic acid esters / p-Hydroxybenzoic acid alkyl esters
[(1aS,2aR,5R,5aS,6R,7S,7aR)-5,7-dihydroxy-2a,7a-dimethyl-5-propan-2-yl-2,3,4,5a,6,7-hexahydro-1aH-azuleno[6,7-b]oxiren-6-yl] 4-hydroxybenzoate 11090418 Click to see CC(C)C1(CCC2(C1C(C(C3(C(C2)O3)C)O)OC(=O)C4=CC=C(C=C4)O)C)O 390.50 unknown https://doi.org/10.1016/S0031-9422(01)00307-7
[2-hydroxy-4-methyl-4-(3-oxobutyl)-6a-propan-2-yl-3,3a,5,6-tetrahydro-2H-cyclopenta[b]furan-3-yl] 4-hydroxybenzoate 78200715 Click to see 390.50 unknown https://doi.org/10.1021/NP020020+
Kuhistaferone 637004 Click to see 390.50 unknown https://doi.org/10.1021/NP020020+
https://doi.org/10.1248/CPB.49.707
> Lipids and lipid-like molecules / Prenol lipids / Monoterpenoids / Bicyclic monoterpenoids
Kuhistanol D 10338460 Click to see 358.50 unknown https://doi.org/10.1021/NP990338A
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids
(6-Formyl-3-hydroxy-8a-methyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl) 4-hydroxybenzoate 85428860 Click to see CC(C)C1(CCC2(C1C(CC(=CC2)C=O)OC(=O)C3=CC=C(C=C3)O)C)O 372.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4R,7R,8aR)-3,7-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,7,8-hexahydroazulen-4-yl] 4-hydroxy-3-methoxybenzoate 162920562 Click to see 404.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4R,7R,8aR)-3,7-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,7,8-hexahydroazulen-4-yl] 4-methoxybenzoate 162979689 Click to see 388.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4R,7S,8aR)-3,7-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,7,8-hexahydroazulen-4-yl] 4-hydroxybenzoate 162877930 Click to see 374.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4R,8R,8aS)-3,8-dihydroxy-6,8a-dimethyl-1-oxo-3-propan-2-yl-3a,4,5,8-tetrahydro-2H-azulen-4-yl] 4-hydroxy-3-methoxybenzoate 636500 Click to see 418.50 unknown https://doi.org/10.1016/S0031-9422(01)00307-7
[(3R,3aS,4S,6R,8aR)-3,6-dihydroxy-6,8a-dimethyl-3-propan-2-yl-2,3a,4,5-tetrahydro-1H-azulen-4-yl] 4-hydroxybenzoate 13875695 Click to see CC(C)C1(CCC2(C1C(CC(C=C2)(C)O)OC(=O)C3=CC=C(C=C3)O)C)O 374.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,6R,8aS)-3,6-dihydroxy-6,8a-dimethyl-3-propan-2-yl-2,3a,4,5-tetrahydro-1H-azulen-4-yl] 4-hydroxy-3-methoxybenzoate 162971747 Click to see 404.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,6R,8aS)-3,6-dihydroxy-6,8a-dimethyl-3-propan-2-yl-2,3a,4,5-tetrahydro-1H-azulen-4-yl] 4-hydroxybenzoate 163005866 Click to see 374.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,7R,8aR)-3,7-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,7,8-hexahydroazulen-4-yl] 4-hydroxy-3-methoxybenzoate 14466075 Click to see CC1=CC(C2C(CCC2(C(C)C)O)(CC1O)C)OC(=O)C3=CC(=C(C=C3)O)OC 404.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,7R,8aR)-3,7-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,7,8-hexahydroazulen-4-yl] 4-methoxybenzoate 15545788 Click to see CC1=CC(C2C(CCC2(C(C)C)O)(CC1O)C)OC(=O)C3=CC=C(C=C3)OC 388.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,8aR)-3-hydroxy-6-(hydroxymethyl)-8a-methyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-methoxybenzoate 15545786 Click to see 388.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,8aR)-6-formyl-3-hydroxy-8a-methyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate 11187908 Click to see CC(C)C1(CCC2(C1C(CC(=CC2)C=O)OC(=O)C3=CC=C(C=C3)O)C)O 372.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3R,3aS,4S,8aS)-3-hydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate 91747167 Click to see 358.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
https://doi.org/10.1007/BF00630427
https://doi.org/10.1016/S0031-9422(01)00307-7
https://doi.org/10.1007/BF02236437
[(3R,3aS,4S,8R,8aS)-3,8-dihydroxy-6,8a-dimethyl-1-oxo-3-propan-2-yl-3a,4,5,8-tetrahydro-2H-azulen-4-yl] 4-hydroxy-3-methoxybenzoate 12041553 Click to see 418.50 unknown https://doi.org/10.1016/S0031-9422(01)00307-7
[(3R,3aS,4S,8S,8aS)-3,8-dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxy-3-methoxybenzoate 15545787 Click to see 404.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
[(3S,8aR)-3-hydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxy-3-methoxybenzoate 389016 Click to see CC1=CCC2(CCC(C2C(C1)OC(=O)C3=CC(=C(C=C3)O)OC)(C(C)C)O)C 388.50 unknown https://doi.org/10.1007/BF02236437
10-Hydroxy-4,7-dimethyl-10-(methylethyl)bicyclo[5.3.0]dec-4-en-2-yl 3-hydroxy-4-methoxybenzoate 4524229 Click to see 388.50 unknown https://doi.org/10.1007/BF02236437
2-[(5E)-2-hydroxy-6,10-dimethylundeca-5,9-dien-2-yl]-2,3-dihydro-1-benzofuran-5-carboxylic acid 10642156 Click to see 358.50 unknown https://doi.org/10.1248/CPB.49.707
3-[(2E,6E,10R)-10,11-dihydroxy-3,7,11-trimethyldodeca-2,6-dienyl]-4-hydroxybenzoic acid 163047372 Click to see 376.50 unknown https://doi.org/10.1021/NP990338A
3-[(2E,6R,7R)-6,7-dihydroxy-3,7,11-trimethyldodeca-2,10-dienyl]-4-hydroxybenzoic acid 162914207 Click to see 376.50 unknown https://doi.org/10.1021/NP990338A
3-Farnesyl-4-hydroxybenzoesaure 54248366 Click to see 342.50 unknown https://doi.org/10.1021/NP990338A
3a-methyl-6-methylidene-1-propan-2-yl-3,4,5,7,8,8a-hexahydro-2H-azulene-1,5,8-triol 14681669 Click to see 254.36 unknown https://doi.org/10.1016/S0031-9422(01)00307-7
4-hydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzoic acid 10914851 Click to see 342.50 unknown https://doi.org/10.1021/NP990338A
4-hydroxy-3-[(E,6S)-6-hydroxy-6-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-3-methylhex-2-enyl]benzoic acid 162976080 Click to see 392.50 unknown https://doi.org/10.1021/NP990338A
Ferutidin 10172562 Click to see CC1=CCC2(CCC(C2C(C1)OC(=O)C3=CC=C(C=C3)OC)(C(C)C)O)C 372.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
Ferutinin 354654 Click to see 358.50 unknown https://doi.org/10.1016/S0031-9422(00)00197-7
https://doi.org/10.1016/S0031-9422(01)00307-7
https://doi.org/10.1007/BF02236437
Kuhistanicaol J 636501 Click to see 390.50 unknown https://doi.org/10.1016/S0031-9422(01)00307-7
Teferin 10271607 Click to see CC1=CCC2(CCC(C2C(C1)OC(=O)C3=CC(=C(C=C3)O)OC)(C(C)C)O)C 388.50 unknown https://doi.org/10.1007/BF02236437
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Germacrane sesquiterpenoids
Ugaferin 139291911 Click to see 448.50 unknown https://doi.org/10.1007/BF02236437
> Lipids and lipid-like molecules / Prenol lipids / Sesquiterpenoids / Guaianes
(6-Hydroxy-1a,6-dimethyl-3-propan-2-yl-1b,2,3,4,5,6a,7,7a-octahydroazuleno[1,2-b]oxiren-4-yl) 3-hydroxy-4-methoxybenzoate 162991120 Click to see 404.50 unknown https://doi.org/10.1007/BF02236437
(6-Hydroxy-1a,6-dimethyl-3-propan-2-yl-1b,2,3,4,5,6a,7,7a-octahydroazuleno[1,2-b]oxiren-4-yl) 4-hydroxy-3-methoxybenzoate 162871605 Click to see 404.50 unknown https://doi.org/10.1007/BF02236437
Tenuferidin 14391700 Click to see 374.50 unknown https://doi.org/10.1007/BF02236437
> Lipids and lipid-like molecules / Prenol lipids / Terpene lactones
5-(2,5-dihydroxyphenyl)-3-[(3E)-4,8-dimethylnona-3,7-dienyl]-5-methoxyuran-2-one 162872973 Click to see 372.50 unknown https://doi.org/10.1021/NP990338A
> Organic oxygen compounds / Organooxygen compounds / Carbohydrates and carbohydrate conjugates / Monosaccharides / Hexoses / Hexose phosphates
beta-D-galactose 6-phosphate 449526 Click to see 260.14 unknown https://doi.org/10.1021/NP990338A
> Organoheterocyclic compounds / Coumarans
(2R,3S)-3-hydroxy-2-[5-[(E)-2-hydroxyhept-4-en-2-yl]-2-methyloxolan-2-yl]-2,3-dihydro-1-benzofuran-5-carboxylic acid 101103881 Click to see 376.40 unknown https://doi.org/10.1248/CPB.49.707
> Organoheterocyclic compounds / Piperazinopiperidines
11,14-Dihydroxy-16-(hydroxymethyl)-13-methoxy-12,20-dimethyl-5-oxa-8,17,20-triazahexacyclo[15.3.1.03,19.04,8.09,18.010,15]henicosa-10(15),11,13-triene-21-carbonitrile 53462707 Click to see 428.50 unknown https://doi.org/10.1021/NP990338A

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