Pyrethrin

Details

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Internal ID b9d2d506-12fa-4714-92f4-90d188430249
Taxonomy Lipids and lipid-like molecules > Fatty Acyls > Fatty acid esters > Pyrethroids > Pyrethrins
IUPAC Name [(1S)-2-methyl-4-oxo-3-[(2E)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1R,3R)-3-[(E)-3-methoxy-2-methyl-3-oxoprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate
SMILES (Canonical) CC1=C(C(=O)CC1OC(=O)C2C(C2(C)C)C=C(C)C(=O)OC)CC=CC=C
SMILES (Isomeric) CC1=C(C(=O)C[C@@H]1OC(=O)[C@@H]2[C@H](C2(C)C)/C=C(\C)/C(=O)OC)C/C=C/C=C
InChI InChI=1S/C22H28O5/c1-7-8-9-10-15-14(3)18(12-17(15)23)27-21(25)19-16(22(19,4)5)11-13(2)20(24)26-6/h7-9,11,16,18-19H,1,10,12H2,2-6H3/b9-8+,13-11+/t16-,18+,19+/m1/s1
InChI Key VJFUPGQZSXIULQ-QYVAASDLSA-N
Popularity 10,443 references in papers

Physical and Chemical Properties

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Molecular Formula C22H28O5
Molecular Weight 372.50 g/mol
Exact Mass 372.19367399 g/mol
Topological Polar Surface Area (TPSA) 69.70 Ų
XlogP 4.40
Atomic LogP (AlogP) 3.71
H-Bond Acceptor 5
H-Bond Donor 0
Rotatable Bonds 7

Synonyms

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Pyretrin II
(+)-Pyrethronyl (+)-pyrethrate
ENT 7,543
Pyrethrolone, chrysanthemum dicarboxlic acid methyl ester ester
SCHEMBL119631
Chrysanthemumdicarboxylic acid monomethyl ester pyrethrolone ester
Pyrethrolone ester of chrsanthemumdicarboxylic acid monomethyl ester
121-29-9
2-Methyl-4-oxo-3-(penta-2,4-dienyl)cyclopent-2-enyl (1R-(1alphaS*(Z)))(3beta)-3-(3-methoxy-2-methyl-3-oxoprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate
Cyclopropanecarboxylic acid, 3-((1E)-3-methoxy-2-methyl-3-oxo-1-propenyl)-2,2-dimethyl-, (1S)-2-methyl-4-oxo-3-(2Z)-2,4-pentadienyl-2-cyclopenten-1-yl ester, (1R,3R)-
There are more than 10 synonyms. If you wish to see them all click here.

2D Structure

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2D Structure of Pyrethrin

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
Human Intestinal Absorption + 0.9835 98.35%
Caco-2 + 0.6015 60.15%
Blood Brain Barrier + 0.7000 70.00%
Human oral bioavailability - 0.5571 55.71%
Subcellular localzation Mitochondria 0.7991 79.91%
OATP2B1 inhibitior - 1.0000 100.00%
OATP1B1 inhibitior + 0.8713 87.13%
OATP1B3 inhibitior + 0.8761 87.61%
MATE1 inhibitior - 0.6800 68.00%
OCT2 inhibitior - 0.8000 80.00%
BSEP inhibitior + 0.9413 94.13%
P-glycoprotein inhibitior + 0.6137 61.37%
P-glycoprotein substrate - 0.6030 60.30%
CYP3A4 substrate + 0.6476 64.76%
CYP2C9 substrate - 1.0000 100.00%
CYP2D6 substrate - 0.9131 91.31%
CYP3A4 inhibition - 0.8116 81.16%
CYP2C9 inhibition - 0.8396 83.96%
CYP2C19 inhibition - 0.6707 67.07%
CYP2D6 inhibition - 0.9503 95.03%
CYP1A2 inhibition - 0.8287 82.87%
CYP2C8 inhibition - 0.6203 62.03%
CYP inhibitory promiscuity - 0.8855 88.55%
UGT catelyzed - 0.0000 0.00%
Carcinogenicity (binary) - 0.7176 71.76%
Carcinogenicity (trinary) Non-required 0.6536 65.36%
Eye corrosion - 0.9551 95.51%
Eye irritation - 0.9520 95.20%
Skin irritation - 0.6553 65.53%
Skin corrosion - 0.9790 97.90%
Ames mutagenesis + 0.5700 57.00%
Human Ether-a-go-go-Related Gene inhibition + 0.7337 73.37%
Micronuclear - 0.6000 60.00%
Hepatotoxicity + 0.5302 53.02%
skin sensitisation - 0.5405 54.05%
Respiratory toxicity + 0.5111 51.11%
Reproductive toxicity - 0.5778 57.78%
Mitochondrial toxicity - 0.7125 71.25%
Nephrotoxicity + 0.8612 86.12%
Acute Oral Toxicity (c) II 0.7340 73.40%
Estrogen receptor binding + 0.6986 69.86%
Androgen receptor binding + 0.7114 71.14%
Thyroid receptor binding + 0.6000 60.00%
Glucocorticoid receptor binding + 0.8638 86.38%
Aromatase binding + 0.5873 58.73%
PPAR gamma + 0.5695 56.95%
Honey bee toxicity + 0.9268 92.68%
Biodegradation - 0.8250 82.50%
Crustacea aquatic toxicity + 0.7700 77.00%
Fish aquatic toxicity + 0.9931 99.31%

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 96.46% 94.45%
CHEMBL4040 P28482 MAP kinase ERK2 96.41% 83.82%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 92.94% 96.09%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 92.56% 91.11%
CHEMBL340 P08684 Cytochrome P450 3A4 91.61% 91.19%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 89.72% 85.14%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 86.33% 95.56%
CHEMBL3060 Q9Y345 Glycine transporter 2 85.57% 99.17%
CHEMBL2111367 P27986 PI3-kinase p110-alpha/p85-alpha 85.41% 94.33%
CHEMBL5608 Q16288 NT-3 growth factor receptor 83.02% 95.89%
CHEMBL2007 P16234 Platelet-derived growth factor receptor alpha 81.45% 91.07%
CHEMBL3267 P48736 PI3-kinase p110-gamma subunit 81.13% 95.71%
CHEMBL2996 Q05655 Protein kinase C delta 80.84% 97.79%
CHEMBL4793 Q86TI2 Dipeptidyl peptidase IX 80.68% 96.95%
CHEMBL1907602 P06493 Cyclin-dependent kinase 1/cyclin B1 80.57% 91.24%
CHEMBL2581 P07339 Cathepsin D 80.13% 98.95%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
To see more specific details click the taxa you are interested in.
Bupleurum chinense
Bupleurum falcatum
Bupleurum scorzonerifolium

Cross-Links

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PubChem 6433155
NPASS NPC39122
LOTUS LTS0226509
wikiData Q105287236