Penostatin A

Details

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Internal ID 0d78fa12-5424-4e31-96f1-835370fc3a10
Taxonomy Organic oxygen compounds > Organooxygen compounds > Carbonyl compounds > Cyclic ketones > Cyclohexenones
IUPAC Name (3S,4aR,8R,9aS,9bS)-8-hydroxy-2-methyl-3-[(E)-non-1-enyl]-4a,7,8,9,9a,9b-hexahydro-3H-cyclopenta[f]chromen-5-one
SMILES (Canonical)
SMILES (Isomeric)
InChI InChI=1S/C22H32O3/c1-3-4-5-6-7-8-9-10-21-15(2)11-19-18-14-17(23)12-16(18)13-20(24)22(19)25-21/h9-11,13,17-19,21-23H,3-8,12,14H2,1-2H3/b10-9+/t17-,18+,19-,21-,22+/m0/s1
InChI Key ONCGMAFAIBLDNP-GYGBFYAFSA-N
Popularity 5 references in papers

Physical and Chemical Properties

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Molecular Formula C22H32O3
Molecular Weight 344.50 g/mol
Exact Mass 344.23514488 g/mol
Topological Polar Surface Area (TPSA) 46.50 Ų
XlogP 4.30

Synonyms

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(+)-PENOSTATIN A
DTXSID801045467
Q15425287
(3S,4AR,8R,9AS,9BS)-4A,7,8,9,9A,9B-HEXAHYDRO-8-HYDROXY-2-METHYL-3-(1E)-1-NONEN-1-YLCYCLOPENTA(F)(1)BENZOPYRAN-5(3H)-ONE
(3S,4aR,8R,9aS,9bS)-8-hydroxy-2-methyl-3-[(E)-non-1-enyl]-4a,7,8,9,9a,9b-hexahydro-3H-cyclopenta[f]chromen-5-one
CYCLOPENTA(F)(1)BENZOPYRAN-5(3H)-ONE, 4A,7,8,9,9A,9B-HEXAHYDRO-8-HYDROXY-2-METHYL-3-(1-NONENYL)-, (3.ALPHA.(E),4A.ALPHA.,8.ALPHA.,9A.ALPHA.,9B.BETA.)-(+)-
CYCLOPENTA(F)(1)BENZOPYRAN-5(3H)-ONE, 4A,7,8,9,9A,9B-HEXAHYDRO-8-HYDROXY-2-METHYL-3-(1E)-1-NONEN-1-YL-, (3S,4AR,8R,9AS,9BS)-
CYCLOPENTA(F)(1)BENZOPYRAN-5(3H)-ONE, 4A,7,8,9,9A,9B-HEXAHYDRO-8-HYDROXY-2-METHYL-3-(1E)-1-NONENYL-, (3S,4AR,8R,9AS,9BS)-

2D Structure

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2D Structure of Penostatin A

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 97.99% 98.95%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 95.91% 91.11%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 93.91% 96.09%
CHEMBL4793 Q86TI2 Dipeptidyl peptidase IX 93.67% 96.95%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 93.26% 95.56%
CHEMBL3137262 O60341 LSD1/CoREST complex 92.06% 97.09%
CHEMBL2265 P23141 Acyl coenzyme A:cholesterol acyltransferase 90.61% 85.94%
CHEMBL3060 Q9Y345 Glycine transporter 2 90.32% 99.17%
CHEMBL3401 O75469 Pregnane X receptor 87.76% 94.73%
CHEMBL1293249 Q13887 Kruppel-like factor 5 86.83% 86.33%
CHEMBL4769 O95749 Geranylgeranyl pyrophosphate synthetase 85.95% 92.08%
CHEMBL2996 Q05655 Protein kinase C delta 85.05% 97.79%
CHEMBL2274 Q9H228 Sphingosine 1-phosphate receptor Edg-8 84.48% 100.00%
CHEMBL299 P17252 Protein kinase C alpha 84.43% 98.03%
CHEMBL1806 P11388 DNA topoisomerase II alpha 84.35% 89.00%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 84.21% 90.71%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 83.80% 99.23%
CHEMBL3359 P21462 Formyl peptide receptor 1 83.73% 93.56%
CHEMBL1293267 Q9HC97 G-protein coupled receptor 35 83.47% 89.34%
CHEMBL5103 Q969S8 Histone deacetylase 10 82.38% 90.08%
CHEMBL230 P35354 Cyclooxygenase-2 82.30% 89.63%
CHEMBL4657 Q6V1X1 Dipeptidyl peptidase VIII 81.62% 97.21%
CHEMBL1994 P08235 Mineralocorticoid receptor 81.05% 100.00%
CHEMBL3714130 P46095 G-protein coupled receptor 6 80.85% 97.36%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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There are no matching plants.

Cross-Links

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PubChem 10315501
LOTUS LTS0078293
wikiData Q105194589