Paldimycin B

Details

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Internal ID d09e944e-f5b1-413d-9bb6-47edd354d5c9
Taxonomy Organic acids and derivatives > Carboxylic acids and derivatives > Hexacarboxylic acids and derivatives
IUPAC Name (3S)-3-[(2R,3R,4S,5R,6R)-5-[3-[(2R)-2-acetamido-2-carboxyethyl]sulfanyl-2-[[(2R)-2-acetamido-2-carboxyethyl]sulfanylcarbothioylamino]butanoyl]oxy-6-(acetyloxymethyl)-3-hydroxy-4-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-5-[(1S)-1-(2-methylpropanoyloxy)ethyl]oxan-2-yl]oxyoxan-2-yl]-2,3-dihydroxy-6-imino-5-oxocyclohexene-1-carboxylic acid
SMILES (Canonical)
SMILES (Isomeric)
InChI InChI=1S/C43H62N4O23S3/c1-15(2)39(60)67-18(5)43(63)17(4)66-27(10-26(43)64-9)69-33-31(52)35(42(62)11-24(51)29(44)28(34(42)53)38(58)59)68-25(12-65-21(8)50)32(33)70-40(61)30(16(3)72-13-22(36(54)55)45-19(6)48)47-41(71)73-14-23(37(56)57)46-20(7)49/h15-18,22-23,25-27,30-33,35,44,52-53,62-63H,10-14H2,1-9H3,(H,45,48)(H,46,49)(H,47,71)(H,54,55)(H,56,57)(H,58,59)/t16?,17-,18-,22-,23-,25+,26-,27-,30?,31+,32+,33-,35+,42+,43-/m0/s1
InChI Key HQSNXADXGQAEOU-RNMOKUSESA-N
Popularity 5 references in papers

Physical and Chemical Properties

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Molecular Formula C43H62N4O23S3
Molecular Weight 1099.20 g/mol
Exact Mass 1098.29669776 g/mol
Topological Polar Surface Area (TPSA) 502.00 Ų
XlogP -1.60

Synonyms

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3N3B8RVK1J
Antibiotic 273a1.beta.
Antibiotic 273 A1-beta
101411-71-6
UNII-3N3B8RVK1J
SCHEMBL691985
NS00011800
Q27257702
(3S)-3-[(2R,3R,4S,5R,6R)-5-[3-[(2R)-2-acetamido-2-carboxyethyl]sulfanyl-2-[[(2R)-2-acetamido-2-carboxyethyl]sulfanylcarbothioylamino]butanoyl]oxy-6-(acetyloxymethyl)-3-hydroxy-4-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyl-5-[(1S)-1-(2-methylpropanoyloxy)ethyl]oxan-2-yl]oxyoxan-2-yl]-2,3-dihydroxy-6-imino-5-oxocyclohexene-1-carboxylic acid
2-Amino-5-(3-O-(2,6-dideoxy-4-C-((1S)-1-hydroxyethyl)-3-O-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-allopyranosyl)-5-hydroxy-3,6-dioxo-1-cyclohexene-1-carboxylic acid, 4'-(3-(((2R)-2-acetamido-2-carboxyethyl)thio)-2-((dithiocarboxy)amino)butyrate), 6'-acetate, 4''-C-isobutyrate, S-ester with N-acetyl-L-cysteine
There are more than 10 synonyms. If you wish to see them all click here.

2D Structure

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2D Structure of Paldimycin B

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 99.73% 91.11%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 97.99% 85.14%
CHEMBL2581 P07339 Cathepsin D 97.91% 98.95%
CHEMBL1075094 Q16236 Nuclear factor erythroid 2-related factor 2 95.17% 96.00%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 94.49% 94.45%
CHEMBL3137262 O60341 LSD1/CoREST complex 94.38% 97.09%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 93.87% 96.09%
CHEMBL340 P08684 Cytochrome P450 3A4 92.83% 91.19%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 90.16% 99.23%
CHEMBL221 P23219 Cyclooxygenase-1 90.03% 90.17%
CHEMBL2413 P32246 C-C chemokine receptor type 1 88.41% 89.50%
CHEMBL2111367 P27986 PI3-kinase p110-alpha/p85-alpha 88.39% 94.33%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 88.12% 97.14%
CHEMBL4657 Q6V1X1 Dipeptidyl peptidase VIII 87.19% 97.21%
CHEMBL3060 Q9Y345 Glycine transporter 2 86.28% 99.17%
CHEMBL1293249 Q13887 Kruppel-like factor 5 86.26% 86.33%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 86.09% 93.00%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 85.80% 95.56%
CHEMBL3359 P21462 Formyl peptide receptor 1 85.55% 93.56%
CHEMBL4227 P25090 Lipoxin A4 receptor 84.40% 100.00%
CHEMBL5608 Q16288 NT-3 growth factor receptor 84.01% 95.89%
CHEMBL216 P11229 Muscarinic acetylcholine receptor M1 83.00% 94.23%
CHEMBL253 P34972 Cannabinoid CB2 receptor 82.98% 97.25%
CHEMBL3351 Q13085 Acetyl-CoA carboxylase 1 82.73% 93.04%
CHEMBL5255 O00206 Toll-like receptor 4 82.22% 92.50%
CHEMBL5028 O14672 ADAM10 82.18% 97.50%
CHEMBL226 P30542 Adenosine A1 receptor 81.98% 95.93%
CHEMBL3091268 Q92753 Nuclear receptor ROR-beta 81.72% 95.50%
CHEMBL3437 Q16853 Amine oxidase, copper containing 80.68% 94.00%
CHEMBL1806 P11388 DNA topoisomerase II alpha 80.68% 89.00%
CHEMBL3475 P05121 Plasminogen activator inhibitor-1 80.58% 83.00%
CHEMBL1860 P10827 Thyroid hormone receptor alpha 80.03% 99.15%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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There are no matching plants.

Cross-Links

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PubChem 135565706
LOTUS LTS0073412
wikiData Q105032419