omega-Conotoxin

Details

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Internal ID bc73d80c-10a3-4e6b-a9bc-b68171e03ed4
Taxonomy Organic acids and derivatives > Peptidomimetics > Hybrid peptides
IUPAC Name (3S)-4-[[(4R,7S)-4-[[(2S,3R)-1-[[2-[[(2S)-1-[[(4S,7R,13R,16S,19R)-7-(4-aminobutyl)-16-(3-carbamimidamidopropyl)-4-carbamoyl-13-(hydroxymethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]carbamoyl]-6-oxo-1,2,5-dithiazocan-7-yl]amino]-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(4R,7S,10R,16R,22R,25S)-25-amino-7,16,22-tris(4-aminobutyl)-10-methyl-6,9,12,15,18,21,24-heptaoxo-1,2-dithia-5,8,11,14,17,20,23-heptazacyclohexacosane-4-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-oxobutanoic acid
SMILES (Canonical) CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC(=O)O)C(=O)NC3CSSCC(NC3=O)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NC4CSSCC(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC4=O)CCCNC(=N)N)CO)CCCCN)C(=O)N)CCCCN
SMILES (Isomeric) C[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](C(=O)N[C@@H](C(=O)NCC(=O)N[C@@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]3CSSC[C@H](NC3=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@H]4CSSC[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](NC4=O)CCCNC(=N)N)CO)CCCCN)C(=O)N)CCCCN
InChI InChI=1S/C102H172N36O32S7/c1-50(2)34-63(128-87(157)60(20-14-31-113-101(109)110)125-95(165)68(43-141)132-97(167)71-46-174-172-44-55(107)82(152)124-57(17-7-11-28-104)84(154)116-38-75(145)120-56(16-6-10-27-103)83(153)115-37-74(144)119-51(3)81(151)123-59(89(159)134-71)19-9-13-30-106)91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-176-177-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70-47-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(126-96(70)166)21-15-32-114-102(111)112/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)/t51-,52-,55-,56-,57-,58-,59+,60+,61+,62+,63+,64+,65+,66-,67+,68+,69-,70+,71+,72-,73+,79+/m1/s1
InChI Key KNJNGVKTAFTUFL-OCMUWRIYSA-N
Popularity 2 references in papers

Physical and Chemical Properties

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Molecular Formula C102H172N36O32S7
Molecular Weight 2639.20 g/mol
Exact Mass 2638.1016905 g/mol
Topological Polar Surface Area (TPSA) 1310.00 Ų
XlogP -15.10

Synonyms

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CHEMBL439485
BDBM50156213

2D Structure

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2D Structure of omega-Conotoxin

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2107 P61073 C-X-C chemokine receptor type 4 100.00% 93.10%
CHEMBL2581 P07339 Cathepsin D 99.97% 98.95%
CHEMBL236 P41143 Delta opioid receptor 99.92% 99.35%
CHEMBL4040 P28482 MAP kinase ERK2 99.56% 83.82%
CHEMBL4777 P25929 Neuropeptide Y receptor type 1 99.50% 96.67%
CHEMBL5852 Q96P65 Pyroglutamylated RFamide peptide receptor 99.48% 85.00%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 99.47% 91.11%
CHEMBL1907594 P30926 Neuronal acetylcholine receptor; alpha3/beta4 99.33% 97.23%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 99.28% 96.09%
CHEMBL1255126 O15151 Protein Mdm4 99.16% 90.20%
CHEMBL4018 P49146 Neuropeptide Y receptor type 2 98.97% 98.94%
CHEMBL3837 P07711 Cathepsin L 98.34% 96.61%
CHEMBL2514 O95665 Neurotensin receptor 2 98.13% 100.00%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 98.08% 94.45%
CHEMBL221 P23219 Cyclooxygenase-1 97.97% 90.17%
CHEMBL5163 Q9NY46 Sodium channel protein type III alpha subunit 97.96% 96.90%
CHEMBL2094135 Q96BI3 Gamma-secretase 97.83% 98.05%
CHEMBL3137262 O60341 LSD1/CoREST complex 97.54% 97.09%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 97.46% 97.14%
CHEMBL3060 Q9Y345 Glycine transporter 2 97.45% 99.17%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 97.38% 93.00%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 97.36% 90.71%
CHEMBL259 P32245 Melanocortin receptor 4 97.11% 95.38%
CHEMBL4296 Q15858 Sodium channel protein type IX alpha subunit 97.03% 96.11%
CHEMBL2492 P36544 Neuronal acetylcholine receptor protein alpha-7 subunit 96.75% 88.42%
CHEMBL3392948 Q9NP59 Solute carrier family 40 member 1 96.56% 95.00%
CHEMBL2208 P49137 MAP kinase-activated protein kinase 2 96.50% 95.20%
CHEMBL4462 Q8IXJ6 NAD-dependent deacetylase sirtuin 2 95.78% 90.24%
CHEMBL2072 P35499 Sodium channel protein type IV alpha subunit 95.57% 92.32%
CHEMBL242 Q92731 Estrogen receptor beta 95.54% 98.35%
CHEMBL4506 Q96EB6 NAD-dependent deacetylase sirtuin 1 95.39% 88.33%
CHEMBL1795139 Q8IU80 Transmembrane protease serine 6 95.00% 98.33%
CHEMBL5261 Q7L7X3 Serine/threonine-protein kinase TAO1 94.99% 89.33%
CHEMBL1907589 P17787 Neuronal acetylcholine receptor; alpha4/beta2 94.68% 94.55%
CHEMBL4187 Q99250 Sodium channel protein type II alpha subunit 94.65% 95.50%
CHEMBL2288 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 94.41% 91.71%
CHEMBL3359 P21462 Formyl peptide receptor 1 94.30% 93.56%
CHEMBL1075317 P61964 WD repeat-containing protein 5 93.71% 96.33%
CHEMBL3176 O43603 Galanin receptor 2 93.43% 98.89%
CHEMBL4461 Q9NTG7 NAD-dependent deacetylase sirtuin 3 93.39% 94.36%
CHEMBL4123 P30989 Neurotensin receptor 1 92.96% 96.67%
CHEMBL4101 P17612 cAMP-dependent protein kinase alpha-catalytic subunit 92.62% 82.86%
CHEMBL3091268 Q92753 Nuclear receptor ROR-beta 92.57% 95.50%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 92.54% 97.64%
CHEMBL2821 P00748 Coagulation factor XII 92.30% 96.21%
CHEMBL3468 P55210 Caspase-7 92.28% 95.68%
CHEMBL1860 P10827 Thyroid hormone receptor alpha 91.80% 99.15%
CHEMBL1907603 Q05586 Glutamate NMDA receptor; GRIN1/GRIN2B 91.31% 95.89%
CHEMBL5103 Q969S8 Histone deacetylase 10 90.97% 90.08%
CHEMBL5966 P55899 IgG receptor FcRn large subunit p51 90.91% 90.93%
CHEMBL5701 Q9H2K8 Serine/threonine-protein kinase TAO3 90.12% 96.67%
CHEMBL1907591 P30926 Neuronal acetylcholine receptor; alpha4/beta4 89.89% 100.00%
CHEMBL3437 Q16853 Amine oxidase, copper containing 89.55% 94.00%
CHEMBL4633 P22001 Voltage-gated potassium channel subunit Kv1.3 89.40% 100.00%
CHEMBL2413 P32246 C-C chemokine receptor type 1 89.30% 89.50%
CHEMBL4227 P25090 Lipoxin A4 receptor 89.26% 100.00%
CHEMBL2095164 P49354 Geranylgeranyl transferase type I 89.24% 92.80%
CHEMBL344 Q99705 Melanin-concentrating hormone receptor 1 89.09% 92.50%
CHEMBL1075094 Q16236 Nuclear factor erythroid 2-related factor 2 88.73% 96.00%
CHEMBL2001 Q9H244 Purinergic receptor P2Y12 88.36% 96.00%
CHEMBL2535 P11166 Glucose transporter 88.14% 98.75%
CHEMBL220 P22303 Acetylcholinesterase 88.07% 94.45%
CHEMBL340 P08684 Cytochrome P450 3A4 87.79% 91.19%
CHEMBL4625 Q07817 Apoptosis regulator Bcl-X 87.34% 99.77%
CHEMBL1293287 P14735 Insulin-degrading enzyme 86.49% 88.10%
CHEMBL5043 Q6P179 Endoplasmic reticulum aminopeptidase 2 86.21% 91.81%
CHEMBL3892 Q99500 Sphingosine 1-phosphate receptor Edg-3 86.10% 97.29%
CHEMBL2069156 Q14145 Kelch-like ECH-associated protein 1 85.79% 82.38%
CHEMBL2073 P07947 Tyrosine-protein kinase YES 85.69% 83.14%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 85.65% 96.47%
CHEMBL4581 P52732 Kinesin-like protein 1 85.57% 93.18%
CHEMBL5896 O75164 Lysine-specific demethylase 4A 85.13% 99.09%
CHEMBL3230 O95977 Sphingosine 1-phosphate receptor Edg-6 83.57% 94.01%
CHEMBL4071 P08311 Cathepsin G 83.34% 94.64%
CHEMBL6175 Q9H3R0 Lysine-specific demethylase 4C 82.61% 96.69%
CHEMBL1628481 P35414 Apelin receptor 82.44% 97.89%
CHEMBL5939 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 81.96% 100.00%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 81.89% 95.56%
CHEMBL3830 Q2M2I8 Adaptor-associated kinase 81.61% 83.10%
CHEMBL3880 P07900 Heat shock protein HSP 90-alpha 80.73% 96.21%
CHEMBL4801 P29466 Caspase-1 80.47% 96.85%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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Cross-Links

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PubChem 91933123
LOTUS LTS0086119
wikiData Q105143438