Narciclasine
| Internal ID | d77472da-cdd0-477d-90a4-58978dbd6e3a |
| Taxonomy | Organoheterocyclic compounds > Quinolines and derivatives > Benzoquinolines > Phenanthridines and derivatives |
| IUPAC Name | (2S,3R,4S,4aR)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one |
| SMILES (Canonical) | C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O |
| SMILES (Isomeric) | C1OC2=C(O1)C(=C3C(=C2)C4=C[C@@H]([C@H]([C@H]([C@@H]4NC3=O)O)O)O)O |
| InChI | InChI=1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1 |
| InChI Key | LZAZURSABQIKGB-AEKGRLRDSA-N |
| Popularity | 101 references in papers |
| Molecular Formula | C14H13NO7 |
| Molecular Weight | 307.25 g/mol |
| Exact Mass | 307.06920175 g/mol |
| Topological Polar Surface Area (TPSA) | 129.00 Ų |
| XlogP | -1.20 |
| Atomic LogP (AlogP) | -1.29 |
| H-Bond Acceptor | 7 |
| H-Bond Donor | 5 |
| Rotatable Bonds | 0 |
| 29477-83-6 |
| Lycoricidinol |
| Lycoricidin-A |
| Narciclasina |
| Lycorcidinol |
| Nacriclasine |
| NSC 266535 |
| BRN 1087400 |
| NSC266535 |
| C14H13NO7 |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9225 | 92.25% |
| Caco-2 | - | 0.8262 | 82.62% |
| Blood Brain Barrier | - | 0.7250 | 72.50% |
| Human oral bioavailability | + | 0.5429 | 54.29% |
| Subcellular localzation | Mitochondria | 0.5672 | 56.72% |
| OATP2B1 inhibitior | - | 0.8596 | 85.96% |
| OATP1B1 inhibitior | + | 0.8587 | 85.87% |
| OATP1B3 inhibitior | + | 0.9509 | 95.09% |
| MATE1 inhibitior | - | 0.8800 | 88.00% |
| OCT2 inhibitior | - | 1.0000 | 100.00% |
| BSEP inhibitior | - | 0.7983 | 79.83% |
| P-glycoprotein inhibitior | - | 0.9364 | 93.64% |
| P-glycoprotein substrate | - | 0.7677 | 76.77% |
| CYP3A4 substrate | + | 0.5384 | 53.84% |
| CYP2C9 substrate | - | 0.8064 | 80.64% |
| CYP2D6 substrate | - | 0.8666 | 86.66% |
| CYP3A4 inhibition | - | 0.6866 | 68.66% |
| CYP2C9 inhibition | - | 0.7422 | 74.22% |
| CYP2C19 inhibition | - | 0.7077 | 70.77% |
| CYP2D6 inhibition | - | 0.7576 | 75.76% |
| CYP1A2 inhibition | + | 0.5439 | 54.39% |
| CYP2C8 inhibition | - | 0.7575 | 75.75% |
| CYP inhibitory promiscuity | - | 0.6073 | 60.73% |
| UGT catelyzed | + | 0.6000 | 60.00% |
| Carcinogenicity (binary) | - | 0.9900 | 99.00% |
| Carcinogenicity (trinary) | Non-required | 0.6361 | 63.61% |
| Eye corrosion | - | 0.9876 | 98.76% |
| Eye irritation | - | 0.8058 | 80.58% |
| Skin irritation | - | 0.7710 | 77.10% |
| Skin corrosion | - | 0.9388 | 93.88% |
| Ames mutagenesis | - | 0.5200 | 52.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.8581 | 85.81% |
| Micronuclear | + | 0.8400 | 84.00% |
| Hepatotoxicity | + | 0.5375 | 53.75% |
| skin sensitisation | - | 0.7823 | 78.23% |
| Respiratory toxicity | + | 0.5222 | 52.22% |
| Reproductive toxicity | + | 0.8444 | 84.44% |
| Mitochondrial toxicity | + | 0.8125 | 81.25% |
| Nephrotoxicity | + | 0.4625 | 46.25% |
| Acute Oral Toxicity (c) | III | 0.4957 | 49.57% |
| Estrogen receptor binding | + | 0.5271 | 52.71% |
| Androgen receptor binding | + | 0.5838 | 58.38% |
| Thyroid receptor binding | + | 0.5917 | 59.17% |
| Glucocorticoid receptor binding | + | 0.6086 | 60.86% |
| Aromatase binding | - | 0.5442 | 54.42% |
| PPAR gamma | - | 0.5000 | 50.00% |
| Honey bee toxicity | - | 0.8050 | 80.50% |
| Biodegradation | - | 0.7250 | 72.50% |
| Crustacea aquatic toxicity | - | 0.6400 | 64.00% |
| Fish aquatic toxicity | + | 0.7765 | 77.65% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL340 | P08684 | Cytochrome P450 3A4 |
630 nM 630 nM |
Ki Ki |
PMID: 21105682
PMID: 19428250 |
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 98.78% | 91.11% |
| CHEMBL4303 | P08238 | Heat shock protein HSP 90-beta | 98.41% | 96.77% |
| CHEMBL2581 | P07339 | Cathepsin D | 94.82% | 98.95% |
| CHEMBL1806 | P11388 | DNA topoisomerase II alpha | 91.80% | 89.00% |
| CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 90.32% | 95.56% |
| CHEMBL1994 | P08235 | Mineralocorticoid receptor | 88.22% | 100.00% |
| CHEMBL4203 | Q9HAZ1 | Dual specificity protein kinase CLK4 | 87.75% | 94.45% |
| CHEMBL3880 | P07900 | Heat shock protein HSP 90-alpha | 87.24% | 96.21% |
| CHEMBL3137262 | O60341 | LSD1/CoREST complex | 87.23% | 97.09% |
| CHEMBL3038477 | P67870 | Casein kinase II alpha/beta | 85.54% | 99.23% |
| CHEMBL5845 | P23415 | Glycine receptor subunit alpha-1 | 84.91% | 90.71% |
| CHEMBL1951 | P21397 | Monoamine oxidase A | 83.17% | 91.49% |
| CHEMBL4296 | Q15858 | Sodium channel protein type IX alpha subunit | 82.64% | 96.11% |
| CHEMBL2535 | P11166 | Glucose transporter | 82.49% | 98.75% |
| CHEMBL5608 | Q16288 | NT-3 growth factor receptor | 82.34% | 95.89% |
| CHEMBL3251 | P19838 | Nuclear factor NF-kappa-B p105 subunit | 81.36% | 96.09% |
| CHEMBL2635 | P51452 | Dual specificity protein phosphatase 3 | 80.56% | 94.00% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| Amaryllidaceae |
| Crinum asiaticum |
| Hymenocallis littoralis |
| Lycoris radiata |
| Lycoris sanguinea |
| Lycoris squamigera |
| Lycoris traubii |
| Scadoxus multiflorus subsp. multiflorus |
| Sternbergia lutea |
| PubChem | 72376 |
| NPASS | NPC182257 |
| ChEMBL | CHEMBL98745 |
| LOTUS | LTS0202973 |
| wikiData | Q18379239 |