Naphthalene-1,4,5-triol
| Internal ID | 542ab48c-d06e-4110-be45-52b332119637 |
| Taxonomy | Benzenoids > Naphthalenes > Naphthols and derivatives |
| IUPAC Name | naphthalene-1,4,5-triol |
| SMILES (Canonical) | C1=CC2=C(C=CC(=C2C(=C1)O)O)O |
| SMILES (Isomeric) | C1=CC2=C(C=CC(=C2C(=C1)O)O)O |
| InChI | InChI=1S/C10H8O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,11-13H |
| InChI Key | NHEVNUARLCWEED-UHFFFAOYSA-N |
| Popularity | 26 references in papers |
| Molecular Formula | C10H8O3 |
| Molecular Weight | 176.17 g/mol |
| Exact Mass | 176.047344113 g/mol |
| Topological Polar Surface Area (TPSA) | 60.70 Ų |
| XlogP | 2.00 |
| Atomic LogP (AlogP) | 1.96 |
| H-Bond Acceptor | 3 |
| H-Bond Donor | 3 |
| Rotatable Bonds | 0 |
| 1,4,5-Naphthalenetriol |
| 481-40-3 |
| 1,4,5-Trihydroxynaphthalene |
| UNII-41I30K2F5W |
| 41I30K2F5W |
| EINECS 207-568-0 |
| DTXSID3032759 |
| a-Hydrojuglone |
| alpha-Hydrojuglone |
| NCGC00091508-01 |
| There are more than 10 synonyms. If you wish to see them all click here. |
| Target | Value | Probability (raw) | Probability (%) |
|---|---|---|---|
| Human Intestinal Absorption | + | 0.9916 | 99.16% |
| Caco-2 | + | 0.6689 | 66.89% |
| Blood Brain Barrier | - | 0.6000 | 60.00% |
| Human oral bioavailability | + | 0.5857 | 58.57% |
| Subcellular localzation | Mitochondria | 0.5449 | 54.49% |
| OATP2B1 inhibitior | - | 1.0000 | 100.00% |
| OATP1B1 inhibitior | + | 0.9655 | 96.55% |
| OATP1B3 inhibitior | + | 0.9460 | 94.60% |
| MATE1 inhibitior | - | 0.9600 | 96.00% |
| OCT2 inhibitior | - | 0.9500 | 95.00% |
| BSEP inhibitior | - | 0.9072 | 90.72% |
| P-glycoprotein inhibitior | - | 0.9625 | 96.25% |
| P-glycoprotein substrate | - | 0.9746 | 97.46% |
| CYP3A4 substrate | - | 0.7147 | 71.47% |
| CYP2C9 substrate | - | 0.8333 | 83.33% |
| CYP2D6 substrate | + | 0.3949 | 39.49% |
| CYP3A4 inhibition | - | 0.5694 | 56.94% |
| CYP2C9 inhibition | + | 0.5398 | 53.98% |
| CYP2C19 inhibition | + | 0.6960 | 69.60% |
| CYP2D6 inhibition | - | 0.8470 | 84.70% |
| CYP1A2 inhibition | + | 0.9499 | 94.99% |
| CYP2C8 inhibition | - | 0.8748 | 87.48% |
| CYP inhibitory promiscuity | + | 0.6348 | 63.48% |
| UGT catelyzed | + | 0.8000 | 80.00% |
| Carcinogenicity (binary) | - | 0.7345 | 73.45% |
| Carcinogenicity (trinary) | Non-required | 0.4870 | 48.70% |
| Eye corrosion | - | 0.9750 | 97.50% |
| Eye irritation | + | 0.9946 | 99.46% |
| Skin irritation | + | 0.7373 | 73.73% |
| Skin corrosion | - | 0.9274 | 92.74% |
| Ames mutagenesis | + | 0.8400 | 84.00% |
| Human Ether-a-go-go-Related Gene inhibition | - | 0.7790 | 77.90% |
| Micronuclear | - | 0.6482 | 64.82% |
| Hepatotoxicity | + | 0.8125 | 81.25% |
| skin sensitisation | + | 0.6552 | 65.52% |
| Respiratory toxicity | - | 0.8000 | 80.00% |
| Reproductive toxicity | - | 0.7556 | 75.56% |
| Mitochondrial toxicity | - | 0.6000 | 60.00% |
| Nephrotoxicity | - | 0.6112 | 61.12% |
| Acute Oral Toxicity (c) | III | 0.8390 | 83.90% |
| Estrogen receptor binding | + | 0.8872 | 88.72% |
| Androgen receptor binding | + | 0.5989 | 59.89% |
| Thyroid receptor binding | + | 0.6262 | 62.62% |
| Glucocorticoid receptor binding | + | 0.8087 | 80.87% |
| Aromatase binding | - | 0.5631 | 56.31% |
| PPAR gamma | + | 0.7765 | 77.65% |
| Honey bee toxicity | - | 0.9653 | 96.53% |
| Biodegradation | - | 0.5250 | 52.50% |
| Crustacea aquatic toxicity | + | 0.6200 | 62.00% |
| Fish aquatic toxicity | + | 0.9063 | 90.63% |
Proven Targets:
| CHEMBL ID | UniProt ID | Name | Min activity | Assay type | Source |
|---|---|---|---|---|---|
| CHEMBL1293255 | P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD+] |
7943.3 nM |
Potency |
via CMAUP
|
| CHEMBL2903 | P16050 | Arachidonate 15-lipoxygenase |
158.5 nM 158.5 nM |
Potency Potency |
via Super-PRED
via CMAUP |
| CHEMBL1293236 | P46063 | ATP-dependent DNA helicase Q1 |
3981.1 nM |
Potency |
via CMAUP
|
| CHEMBL2487 | P05067 | Beta amyloid A4 protein |
4520 nM |
Potency |
via CMAUP
|
| CHEMBL4801 | P29466 | Caspase-1 |
31622.8 nM |
Potency |
via CMAUP
|
| CHEMBL4159 | Q99714 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein |
1258.9 nM 12589.3 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL1293224 | P10636 | Microtubule-associated protein tau |
4970 nM |
Potency |
via CMAUP
|
| CHEMBL1947 | P10828 | Thyroid hormone receptor beta-1 |
28183.8 nM |
Potency |
via CMAUP
|
| CHEMBL1963 | P16473 | Thyroid stimulating hormone receptor |
7943.3 nM 7943.3 nM |
Potency Potency |
via CMAUP
via CMAUP |
| CHEMBL1075138 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 |
562.3 nM 562.3 nM |
Potency Potency |
via CMAUP
via Super-PRED |
Predicted Targets (via Super-PRED):
| CHEMBL ID | UniProt ID | Name | Probability | Model accuracy |
|---|---|---|---|---|
| CHEMBL5619 | P27695 | DNA-(apurinic or apyrimidinic site) lyase | 96.62% | 91.11% |
| CHEMBL1951 | P21397 | Monoamine oxidase A | 96.25% | 91.49% |
| CHEMBL3108638 | O15164 | Transcription intermediary factor 1-alpha | 90.28% | 95.56% |
| CHEMBL1860 | P10827 | Thyroid hormone receptor alpha | 87.15% | 99.15% |
| CHEMBL3192 | Q9BY41 | Histone deacetylase 8 | 82.11% | 93.99% |
| CHEMBL3401 | O75469 | Pregnane X receptor | 80.49% | 94.73% |
Below are displayed all the plants proven (via scientific papers) to contain this
compound!
To see more specific details click the taxa you are interested in.
To see more specific details click the taxa you are interested in.
| Juglans regia |
| PubChem | 3083585 |
| NPASS | NPC67250 |
| ChEMBL | CHEMBL1331245 |