N(1)Gly-Asn-Trp-His-Gly-DL-Gly(Ac)-Ala-DL-Pro-Asp(1)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH

Details

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Internal ID cfba95d8-395d-4ad6-9501-621b379dbac4
Taxonomy Organic acids and derivatives > Carboxylic acids and derivatives > Amino acids, peptides, and analogues > Peptides > Cyclic peptides
IUPAC Name (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(3S,12S,15S,18S,25S)-6-acetyl-18-(2-amino-2-oxoethyl)-12-(1H-imidazol-5-ylmethyl)-15-(1H-indol-3-ylmethyl)-3-methyl-2,5,8,11,14,17,20,23,27-nonaoxo-1,4,7,10,13,16,19,22,26-nonazabicyclo[26.3.0]hentriacontane-25-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-amino-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
SMILES (Canonical)
SMILES (Isomeric)
InChI InChI=1S/C103H113N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(46-86(132)110-51-87(133)114-79(44-84(104)130)97(142)119-77(41-61-48-108-70-24-13-10-21-67(61)70)96(141)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)99(144)120-76(40-60-47-107-69-23-12-9-20-66(60)69)95(140)117-72(36-56-16-5-3-6-17-56)91(136)115-73(37-57-18-7-4-8-19-57)93(138)122-80(45-85(105)131)98(143)118-74(38-58-27-31-64(128)32-28-58)92(137)116-75(39-59-29-33-65(129)34-30-59)94(139)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-54,72-83,89,107-109,128-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,132)(H,111,135)(H,113,146)(H,114,133)(H,115,136)(H,116,137)(H,117,140)(H,118,143)(H,119,142)(H,120,144)(H,121,141)(H,122,138)(H,123,145)(H,124,139)(H,125,134)(H,148,149)/t54-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83?,89?/m0/s1
InChI Key QEHKVSXORDXCMU-SOEAEWQVSA-N
Popularity 2 references in papers

Physical and Chemical Properties

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Molecular Formula C103H113N23O23
Molecular Weight 2041.10 g/mol
Exact Mass 2040.84132178 g/mol
Topological Polar Surface Area (TPSA) 714.00 Ų
XlogP 1.70

Synonyms

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There are no found synonyms.

2D Structure

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2D Structure of N(1)Gly-Asn-Trp-His-Gly-DL-Gly(Ac)-Ala-DL-Pro-Asp(1)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 99.93% 98.95%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 99.66% 97.64%
CHEMBL1951 P21397 Monoamine oxidase A 99.46% 91.49%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 99.37% 96.09%
CHEMBL1255126 O15151 Protein Mdm4 99.00% 90.20%
CHEMBL4040 P28482 MAP kinase ERK2 98.98% 83.82%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 98.72% 91.11%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 98.68% 85.14%
CHEMBL3310 Q96DB2 Histone deacetylase 11 98.26% 88.56%
CHEMBL5103 Q969S8 Histone deacetylase 10 98.01% 90.08%
CHEMBL5608 Q16288 NT-3 growth factor receptor 95.80% 95.89%
CHEMBL5043 Q6P179 Endoplasmic reticulum aminopeptidase 2 95.01% 91.81%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 94.73% 95.56%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 94.68% 94.45%
CHEMBL333 P08253 Matrix metalloproteinase-2 93.66% 96.31%
CHEMBL2492 P36544 Neuronal acetylcholine receptor protein alpha-7 subunit 92.68% 88.42%
CHEMBL1907594 P30926 Neuronal acetylcholine receptor; alpha3/beta4 92.23% 97.23%
CHEMBL259 P32245 Melanocortin receptor 4 92.11% 95.38%
CHEMBL2535 P11166 Glucose transporter 92.10% 98.75%
CHEMBL255 P29275 Adenosine A2b receptor 91.94% 98.59%
CHEMBL2093869 P05106 Integrin alpha-IIb/beta-3 91.46% 95.42%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 91.32% 99.23%
CHEMBL1860 P10827 Thyroid hormone receptor alpha 90.85% 99.15%
CHEMBL3202 P48147 Prolyl endopeptidase 90.64% 90.65%
CHEMBL4979 P13866 Sodium/glucose cotransporter 1 90.59% 98.24%
CHEMBL4644 P41968 Melanocortin receptor 3 89.84% 99.52%
CHEMBL3091268 Q92753 Nuclear receptor ROR-beta 89.19% 95.50%
CHEMBL3976 Q9UHL4 Dipeptidyl peptidase II 89.18% 92.29%
CHEMBL5805 Q9NR97 Toll-like receptor 8 88.58% 96.25%
CHEMBL3837 P07711 Cathepsin L 88.50% 96.61%
CHEMBL5163 Q9NY46 Sodium channel protein type III alpha subunit 88.32% 96.90%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 87.40% 93.00%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 87.03% 97.14%
CHEMBL2069156 Q14145 Kelch-like ECH-associated protein 1 86.65% 82.38%
CHEMBL3830 Q2M2I8 Adaptor-associated kinase 86.63% 83.10%
CHEMBL1806 P11388 DNA topoisomerase II alpha 86.39% 89.00%
CHEMBL3137262 O60341 LSD1/CoREST complex 85.77% 97.09%
CHEMBL5896 O75164 Lysine-specific demethylase 4A 85.72% 99.09%
CHEMBL4296 Q15858 Sodium channel protein type IX alpha subunit 85.55% 96.11%
CHEMBL3060 Q9Y345 Glycine transporter 2 85.49% 99.17%
CHEMBL3524 P56524 Histone deacetylase 4 85.20% 92.97%
CHEMBL264 Q9Y5N1 Histamine H3 receptor 85.19% 91.43%
CHEMBL4588 P22894 Matrix metalloproteinase 8 84.39% 94.66%
CHEMBL1795139 Q8IU80 Transmembrane protease serine 6 84.32% 98.33%
CHEMBL2821 P00748 Coagulation factor XII 83.66% 96.21%
CHEMBL3713062 P10646 Tissue factor pathway inhibitor 83.37% 97.33%
CHEMBL2095226 P05556 Integrin alpha-5/beta-1 83.20% 96.39%
CHEMBL3024 P53350 Serine/threonine-protein kinase PLK1 82.93% 97.43%
CHEMBL1907600 Q00535 Cyclin-dependent kinase 5/CDK5 activator 1 82.78% 93.03%
CHEMBL5939 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 82.61% 100.00%
CHEMBL1921 P47901 Vasopressin V1b receptor 82.43% 92.50%
CHEMBL321 P14780 Matrix metalloproteinase 9 81.52% 92.12%
CHEMBL5203 P33316 dUTP pyrophosphatase 81.48% 99.18%
CHEMBL2514 O95665 Neurotensin receptor 2 81.44% 100.00%
CHEMBL4187 Q99250 Sodium channel protein type II alpha subunit 81.23% 95.50%
CHEMBL1293249 Q13887 Kruppel-like factor 5 81.15% 86.33%
CHEMBL2096618 P11274 Bcr/Abl fusion protein 81.02% 85.83%
CHEMBL1795185 Q58F21 Bromodomain testis-specific protein 80.42% 89.76%
CHEMBL4777 P25929 Neuropeptide Y receptor type 1 80.31% 96.67%
CHEMBL3392948 Q9NP59 Solute carrier family 40 member 1 80.08% 95.00%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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Cross-Links

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PubChem 139586488
LOTUS LTS0061379
wikiData Q105219215