Milbemycin alpha28

Details

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Internal ID 703a0a21-6cfe-4ea1-91da-97a1101df273
Taxonomy Phenylpropanoids and polyketides > Macrolides and analogues > Milbemycins
IUPAC Name [(1R,3'R,4S,4'S,5'R,6S,6'R,8R,10Z,13R,14Z,16Z,20R,21R,24S)-3',21,24-trihydroxy-5',6',11,13-tetramethyl-4'-(2-methylbutanoyloxy)-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-22-yl]methyl 1H-pyrrole-2-carboxylate
SMILES (Canonical)
SMILES (Isomeric)
InChI InChI=1S/C41H55NO12/c1-7-24(4)37(45)52-34-25(5)26(6)53-40(35(34)44)19-30-18-29(54-40)14-13-23(3)16-22(2)10-8-11-28-21-49-36-33(43)27(17-31(38(46)51-30)41(28,36)48)20-50-39(47)32-12-9-15-42-32/h8-13,15,17,22,24-26,29-31,33-36,42-44,48H,7,14,16,18-21H2,1-6H3/b10-8-,23-13-,28-11-/t22-,24?,25+,26+,29+,30-,31-,33+,34-,35+,36+,40+,41+/m0/s1
InChI Key LFQNVDAPCWUUFS-SGRPJTFUSA-N
Popularity 2 references in papers

Physical and Chemical Properties

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Molecular Formula C41H55NO12
Molecular Weight 753.90 g/mol
Exact Mass 753.37242619 g/mol
Topological Polar Surface Area (TPSA) 183.00 Ų
XlogP 3.20

Synonyms

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There are no found synonyms.

2D Structure

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2D Structure of Milbemycin alpha28

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 99.19% 96.09%
CHEMBL2581 P07339 Cathepsin D 97.89% 98.95%
CHEMBL3137262 O60341 LSD1/CoREST complex 95.31% 97.09%
CHEMBL253 P34972 Cannabinoid CB2 receptor 94.11% 97.25%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 92.48% 91.11%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 92.43% 95.56%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 90.93% 94.45%
CHEMBL3922 P50579 Methionine aminopeptidase 2 90.01% 97.28%
CHEMBL4793 Q86TI2 Dipeptidyl peptidase IX 89.55% 96.95%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 89.55% 96.47%
CHEMBL2635 P51452 Dual specificity protein phosphatase 3 89.42% 94.00%
CHEMBL226 P30542 Adenosine A1 receptor 89.00% 95.93%
CHEMBL1293249 Q13887 Kruppel-like factor 5 88.07% 86.33%
CHEMBL2179 P04062 Beta-glucocerebrosidase 86.46% 85.31%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 85.69% 97.14%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 84.99% 99.23%
CHEMBL1806 P11388 DNA topoisomerase II alpha 83.21% 89.00%
CHEMBL1994 P08235 Mineralocorticoid receptor 82.60% 100.00%
CHEMBL2996 Q05655 Protein kinase C delta 82.56% 97.79%
CHEMBL3359 P21462 Formyl peptide receptor 1 82.34% 93.56%
CHEMBL1163125 O60885 Bromodomain-containing protein 4 81.63% 97.31%
CHEMBL3145 P42338 PI3-kinase p110-beta subunit 81.52% 98.75%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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There are no matching plants.

Cross-Links

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PubChem 139586512
LOTUS LTS0207337
wikiData Q105151131