A-130A

Details

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Internal ID fb3dd3ab-b37c-43c4-9e19-8937d6d2918f
Taxonomy Lipids and lipid-like molecules > Prenol lipids > Sesterterpenoids
IUPAC Name (E,2S,4R,8S)-8-[(2S,5R,6R,7R,9S)-2-[(2R,4S,5R,6R,9R)-2-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-4,6-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-7-[(2R,5S,6R)-5-methoxy-6-methyloxan-2-yl]oxy-2,6-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-2,4,6-trimethyl-5-oxonon-6-enoic acid
SMILES (Canonical) CC1CCC(OC12C(CC(O2)C3C(CC(C(O3)(CO)O)C)C)C)C4(CCC5(O4)C(C(CC(O5)C(C)C=C(C)C(=O)C(C)CC(C)C(=O)O)OC6CCC(C(O6)C)OC)C)C
SMILES (Isomeric) C[C@@H]1CC[C@@H](O[C@@]12[C@H](C[C@@H](O2)[C@@H]3[C@H](C[C@H]([C@@](O3)(CO)O)C)C)C)[C@@]4(CC[C@@]5(O4)[C@@H]([C@@H](C[C@H](O5)[C@@H](C)/C=C(\C)/C(=O)[C@H](C)C[C@H](C)C(=O)O)O[C@H]6CC[C@@H]([C@H](O6)C)OC)C)C
InChI InChI=1S/C47H78O13/c1-25(19-26(2)41(49)27(3)20-29(5)43(50)51)36-23-37(55-40-16-14-35(53-12)34(10)54-40)33(9)46(56-36)18-17-44(11,60-46)39-15-13-30(6)47(58-39)32(8)22-38(57-47)42-28(4)21-31(7)45(52,24-48)59-42/h19,25,27-40,42,48,52H,13-18,20-24H2,1-12H3,(H,50,51)/b26-19+/t25-,27+,28-,29-,30+,31+,32-,33+,34+,35-,36-,37+,38+,39+,40-,42-,44-,45-,46+,47+/m0/s1
InChI Key LQFPDTISEHAMNQ-JRSQRZRGSA-N
Popularity 3 references in papers

Physical and Chemical Properties

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Molecular Formula C47H78O13
Molecular Weight 851.10 g/mol
Exact Mass 850.54424254 g/mol
Topological Polar Surface Area (TPSA) 169.00 Ų
XlogP 6.80

Synonyms

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A-130A
51257-84-2
Antibiotic A 130A
Antibiotic Ro 21 6150
(2S,4R,8S,E)-8-((2S,2'R,4'S,5R,5'R,7S,7'R,9R,10R,10'R)-2'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-9-(((2R,5S,6R)-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4',10,10'-tetramethyl-1,1',6,6'-tetraoxa[2,7'-bispiro[4.5]decan]-7-yl)-2,4,6-trimethyl-5-oxonon-6-enoic acid
CHEMBL4098414
DTXSID701318162
AKOS040746494
(11(2R,5S,6R),12R)-10-Demethyl-19-de((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)-12-methyl-11-O-(tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)dianemycin
Dianemycin, 10-demethyl-19-de((tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)oxy)-12-methyl-11-O-(tetrahydro-5-methoxy-6-methyl-2H-pyran-2-yl)-, (11R(2R,5S,6R),12R)
There are more than 10 synonyms. If you wish to see them all click here.

2D Structure

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2D Structure of A-130A

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 99.27% 96.09%
CHEMBL4793 Q86TI2 Dipeptidyl peptidase IX 97.43% 96.95%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 96.58% 85.14%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 96.39% 91.11%
CHEMBL3880 P07900 Heat shock protein HSP 90-alpha 95.61% 96.21%
CHEMBL253 P34972 Cannabinoid CB2 receptor 95.21% 97.25%
CHEMBL284 P27487 Dipeptidyl peptidase IV 94.09% 95.69%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 93.93% 97.14%
CHEMBL4187 Q99250 Sodium channel protein type II alpha subunit 91.16% 95.50%
CHEMBL2581 P07339 Cathepsin D 90.78% 98.95%
CHEMBL340 P08684 Cytochrome P450 3A4 88.79% 91.19%
CHEMBL1293249 Q13887 Kruppel-like factor 5 88.02% 86.33%
CHEMBL2413 P32246 C-C chemokine receptor type 1 87.82% 89.50%
CHEMBL3976 Q9UHL4 Dipeptidyl peptidase II 87.28% 92.29%
CHEMBL2274 Q9H228 Sphingosine 1-phosphate receptor Edg-8 86.63% 100.00%
CHEMBL3137262 O60341 LSD1/CoREST complex 85.70% 97.09%
CHEMBL4685 P14902 Indoleamine 2,3-dioxygenase 85.47% 96.38%
CHEMBL236 P41143 Delta opioid receptor 85.22% 99.35%
CHEMBL3060 Q9Y345 Glycine transporter 2 85.19% 99.17%
CHEMBL218 P21554 Cannabinoid CB1 receptor 85.11% 96.61%
CHEMBL5255 O00206 Toll-like receptor 4 84.08% 92.50%
CHEMBL2007 P16234 Platelet-derived growth factor receptor alpha 84.02% 91.07%
CHEMBL4227 P25090 Lipoxin A4 receptor 83.12% 100.00%
CHEMBL4588 P22894 Matrix metalloproteinase 8 82.86% 94.66%
CHEMBL5608 Q16288 NT-3 growth factor receptor 82.41% 95.89%
CHEMBL1907603 Q05586 Glutamate NMDA receptor; GRIN1/GRIN2B 82.26% 95.89%
CHEMBL2083 P15090 Fatty acid binding protein adipocyte 82.05% 95.71%
CHEMBL206 P03372 Estrogen receptor alpha 82.04% 97.64%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 82.03% 94.45%
CHEMBL233 P35372 Mu opioid receptor 81.75% 97.93%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 80.80% 99.23%
CHEMBL1744525 P43490 Nicotinamide phosphoribosyltransferase 80.51% 96.25%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 80.11% 96.47%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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There are no matching plants.

Cross-Links

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PubChem 6441669
LOTUS LTS0057651
wikiData Q105155501