Kanamycin

Details

• Internal ID: a3f8cf43-8b1e-4f1f-96fa-c435552cd9fb
• Taxonomy: Organic oxygen compounds > Organooxygen compounds > Carbohydrates and carbohydrate conjugates > 2-deoxystreptamine aminoglycosides > 4,6-disubstituted 2-deoxystreptamines
• IUPAC Name: (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
• InChI: InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1
• InChI Key: SBUJHOSQTJFQJX-NOAMYHISSA-N
• Popularity: 42,322 references in papers

Physical and Chemical Properties

• Molecular Formula: C₁₈H₃₆N₄O₁₁
• Molecular Weight: 484.50 g/mol
• Exact Mass: 484.23805798 g/mol
• Topological Polar Surface Area (TPSA): 283.00 Ų
• XlogP: -6.90

Synonyms

• Kanamicina
• Kanamycine
• Kanamycinum
• 8063-07-8
• Kanamycins
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
• D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-2-deoxy-
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}oxane-3,4,5-triol
• Kanamycin Complex
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy)-2-hydroxycyclohexyl)oxy)oxane-3,4,5-triol
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-((1R,2R,3S,4R,6S)-4,6-diamino-3-((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl)oxy-2-hydroxycyclohexyl)oxyoxane-3,4,5-triol
• RefChem:5930
• RUC37XUP2P
• CHEBI:6104
• DTXSID2041171
• CHEBI:24951
• A07AA08
• J01GB04
• S01AA24
• 200-411-7
• 232-512-7
• KANAMYCIN A
• 59-01-8
• KanamycinA
• Kanamycin Base
• Kanamycin sulfate
• Kanamycin A monosulfate
• 4,6-Diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside
• EQK9Q303C5
• KAN
• CHEBI:17630
• C18H36N4O11
• 1174286-24-8
• Kanamycin A Deuterated
• Kanamycin (sulfate)
• Kanamicina [Italian]
• KM (the Antibiotic)
• Kanamycin [INN:BAN]
• Kanamycine [INN-French]
• Kanamycinum [INN-Latin]
• 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside
• (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]tetrahydropyran-3,4,5-triol
• HSDB 3107
• EINECS 200-411-7
• BRN 0061647
• UNII-EQK9Q303C5
• DTXSID3023184
• Liposomal Kanamycin
• Prestwick3_000394
• Kantrex (1:1 sulfate)
• Klebcil (1:1 sulfate)
• KANAMYCIN A [MI]
• KANAMYCIN A [HSDB]
• SCHEMBL2735
• CHEMBL1384
• Glucopyranoside, 4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-, D-
• BSPBio_000607
• D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1,4))-2-deoxy-
• DivK1c_000024
• KANAMYCIN A [WHO-IP]
• BPBio1_000669
• orb1992991
• GTPL12132
• KBio1_000024
• Kanamycin A Deuterated (>90%)
• MSK7706
• NINDS_000024
• 7227b
• BDBM50031282
• EBC-12280
• MFCD00070289
• Amikacin EP Impurity D; Kanamycin A
• AKOS025293505
• AK30116
• DB01172
• IDI1_000024
• SMP2_000007
• NCGC00179506-01
• NCGC00179506-05
• 2-(aminomethyl)-6-[4,6-diamino-3-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
• AS-14003
• D-Streptamine, O-3-amino-3-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1.fwdarw.4)]-2-deoxy-
• HY-16566
• AB00513827
• CS-0006792
• NS00098990
• C01822
• EN300-19735925
• BRD-K08327065-065-01-9
• BRD-K08327065-065-04-3
• Q27094615
• (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
• (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3,4,5-triol
• D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-2-DEOXY-
• D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-
• D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.4))-2-deoxy-
• O-3-Amino-3-deoxy-.alpha.-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy-D-streptamine
• O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
No predicted properties yet!

Targets

Proven Targets:

No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL3137262	O60341	LSD1/CoREST complex	97.33%	97.09%
CHEMBL5619	P27695	DNA-(apurinic or apyrimidinic site) lyase	96.25%	91.11%
CHEMBL226	P30542	Adenosine A1 receptor	92.72%	95.93%
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	92.45%	96.09%
CHEMBL3589	P55263	Adenosine kinase	91.51%	98.05%
CHEMBL6136	O60341	Lysine-specific histone demethylase 1	86.66%	95.58%
CHEMBL4016	P42262	Glutamate receptor ionotropic, AMPA 2	84.52%	86.92%
CHEMBL3880	P07900	Heat shock protein HSP 90-alpha	82.84%	96.21%
CHEMBL4101	P17612	cAMP-dependent protein kinase alpha-catalytic subunit	81.95%	82.86%
CHEMBL218	P21554	Cannabinoid CB1 receptor	81.89%	96.61%
CHEMBL4187	Q99250	Sodium channel protein type II alpha subunit	80.34%	95.50%

Plants that contains it

• Elateriospermum tapos

Cross-Links

• PubChem: 6032
• LOTUS: LTS0046726
• wikiData: Q27094615