H-Glu-Gly-Gly-Gly-Asn-Arg-Gly-Asp-Pro-Ser-Gly-Val-Cys((E,E)-farnesyl)-OH

Details

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Internal ID 5cceb3d0-ef82-4028-a6f9-7d36dfba3969
Taxonomy Organic Polymers > Polypeptides
IUPAC Name (4S)-4-amino-5-[[2-[[2-[[2-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-3-carboxy-1-[(2S)-2-[[(2S)-1-[[2-[[(2S)-1-[[(1R)-1-carboxy-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid
SMILES (Canonical) CC(C)C(C(=O)NC(CSCC=C(C)CCC=C(C)CCC=C(C)C)C(=O)O)NC(=O)CNC(=O)C(CO)NC(=O)C1CCCN1C(=O)C(CC(=O)O)NC(=O)CNC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)C(CCC(=O)O)N
SMILES (Isomeric) CC(C)[C@@H](C(=O)N[C@@H](CSC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)C(=O)O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)N)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCC(=O)O)N
InChI InChI=1S/C60H97N17O20S/c1-32(2)11-7-12-34(5)13-8-14-35(6)19-22-98-31-41(59(96)97)75-57(94)51(33(3)4)76-48(84)29-70-54(91)40(30-78)74-56(93)42-16-10-21-77(42)58(95)39(24-50(87)88)72-47(83)28-69-53(90)37(15-9-20-65-60(63)64)73-55(92)38(23-43(62)79)71-46(82)27-67-44(80)25-66-45(81)26-68-52(89)36(61)17-18-49(85)86/h11,13,19,33,36-42,51,78H,7-10,12,14-18,20-31,61H2,1-6H3,(H2,62,79)(H,66,81)(H,67,80)(H,68,89)(H,69,90)(H,70,91)(H,71,82)(H,72,83)(H,73,92)(H,74,93)(H,75,94)(H,76,84)(H,85,86)(H,87,88)(H,96,97)(H4,63,64,65)/b34-13+,35-19+/t36-,37-,38-,39-,40-,41-,42-,51-/m0/s1
InChI Key NJFDXFVHDXDFGP-JDYVOHCNSA-N
Popularity 0 references in papers

Physical and Chemical Properties

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Molecular Formula C60H97N17O20S
Molecular Weight 1408.60 g/mol
Exact Mass 1407.68164973 g/mol
Topological Polar Surface Area (TPSA) 631.00 Ų
XlogP -6.40

Synonyms

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There are no found synonyms.

2D Structure

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2D Structure of H-Glu-Gly-Gly-Gly-Asn-Arg-Gly-Asp-Pro-Ser-Gly-Val-Cys((E,E)-farnesyl)-OH

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 99.87% 98.95%
CHEMBL2107 P61073 C-X-C chemokine receptor type 4 99.77% 93.10%
CHEMBL204 P00734 Thrombin 99.62% 96.01%
CHEMBL1795139 Q8IU80 Transmembrane protease serine 6 99.47% 98.33%
CHEMBL236 P41143 Delta opioid receptor 99.28% 99.35%
CHEMBL4801 P29466 Caspase-1 99.27% 96.85%
CHEMBL2514 O95665 Neurotensin receptor 2 98.93% 100.00%
CHEMBL4588 P22894 Matrix metalloproteinase 8 98.71% 94.66%
CHEMBL4777 P25929 Neuropeptide Y receptor type 1 98.55% 96.67%
CHEMBL3468 P55210 Caspase-7 98.52% 95.68%
CHEMBL4018 P49146 Neuropeptide Y receptor type 2 98.45% 98.94%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 98.23% 96.09%
CHEMBL2492 P36544 Neuronal acetylcholine receptor protein alpha-7 subunit 98.00% 88.42%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 97.75% 91.11%
CHEMBL4394 Q9NYA1 Sphingosine kinase 1 97.69% 96.03%
CHEMBL237 P41145 Kappa opioid receptor 97.59% 98.10%
CHEMBL4625 Q07817 Apoptosis regulator Bcl-X 97.37% 99.77%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 96.89% 93.00%
CHEMBL4979 P13866 Sodium/glucose cotransporter 1 96.80% 98.24%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 96.38% 94.45%
CHEMBL4361 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 96.23% 95.52%
CHEMBL3060 Q9Y345 Glycine transporter 2 96.21% 99.17%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 95.82% 96.47%
CHEMBL1907591 P30926 Neuronal acetylcholine receptor; alpha4/beta4 95.69% 100.00%
CHEMBL4123 P30989 Neurotensin receptor 1 95.25% 96.67%
CHEMBL1075094 Q16236 Nuclear factor erythroid 2-related factor 2 95.22% 96.00%
CHEMBL4026 P40763 Signal transducer and activator of transcription 3 95.21% 82.69%
CHEMBL259 P32245 Melanocortin receptor 4 95.18% 95.38%
CHEMBL3359 P21462 Formyl peptide receptor 1 95.11% 93.56%
CHEMBL340 P08684 Cytochrome P450 3A4 94.98% 91.19%
CHEMBL2730 P21980 Protein-glutamine gamma-glutamyltransferase 94.32% 92.38%
CHEMBL1873 P00750 Tissue-type plasminogen activator 94.27% 93.33%
CHEMBL3437 Q16853 Amine oxidase, copper containing 94.04% 94.00%
CHEMBL2001 Q9H244 Purinergic receptor P2Y12 93.95% 96.00%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 93.86% 90.71%
CHEMBL3024 P53350 Serine/threonine-protein kinase PLK1 93.79% 97.43%
CHEMBL1914 P06276 Butyrylcholinesterase 93.75% 95.00%
CHEMBL3776 Q14790 Caspase-8 93.68% 97.06%
CHEMBL3176 O43603 Galanin receptor 2 93.50% 98.89%
CHEMBL2334 P42574 Caspase-3 92.84% 98.25%
CHEMBL1255126 O15151 Protein Mdm4 92.79% 90.20%
CHEMBL249 P25103 Neurokinin 1 receptor 92.66% 99.17%
CHEMBL221 P23219 Cyclooxygenase-1 92.58% 90.17%
CHEMBL335 P18031 Protein-tyrosine phosphatase 1B 92.34% 95.17%
CHEMBL4657 Q6V1X1 Dipeptidyl peptidase VIII 92.13% 97.21%
CHEMBL3392948 Q9NP59 Solute carrier family 40 member 1 91.97% 95.00%
CHEMBL3137262 O60341 LSD1/CoREST complex 91.78% 97.09%
CHEMBL2069156 Q14145 Kelch-like ECH-associated protein 1 91.46% 82.38%
CHEMBL1944495 P28065 Proteasome subunit beta type-9 91.46% 97.50%
CHEMBL230 P35354 Cyclooxygenase-2 90.98% 89.63%
CHEMBL220 P22303 Acetylcholinesterase 90.61% 94.45%
CHEMBL4644 P41968 Melanocortin receptor 3 90.56% 99.52%
CHEMBL4227 P25090 Lipoxin A4 receptor 90.48% 100.00%
CHEMBL4187 Q99250 Sodium channel protein type II alpha subunit 90.40% 95.50%
CHEMBL4608 P33032 Melanocortin receptor 5 90.37% 97.00%
CHEMBL3784 Q09472 Histone acetyltransferase p300 90.28% 93.33%
CHEMBL4769 O95749 Geranylgeranyl pyrophosphate synthetase 89.48% 92.08%
CHEMBL1907594 P30926 Neuronal acetylcholine receptor; alpha3/beta4 89.41% 97.23%
CHEMBL5103 Q969S8 Histone deacetylase 10 89.34% 90.08%
CHEMBL2815 P04629 Nerve growth factor receptor Trk-A 88.48% 87.16%
CHEMBL2413 P32246 C-C chemokine receptor type 1 87.50% 89.50%
CHEMBL2073 P07947 Tyrosine-protein kinase YES 86.83% 83.14%
CHEMBL1744525 P43490 Nicotinamide phosphoribosyltransferase 86.53% 96.25%
CHEMBL2781 P19634 Sodium/hydrogen exchanger 1 86.22% 90.24%
CHEMBL1907603 Q05586 Glutamate NMDA receptor; GRIN1/GRIN2B 85.85% 95.89%
CHEMBL3629 P68400 Casein kinase II alpha 85.64% 98.89%
CHEMBL5608 Q16288 NT-3 growth factor receptor 85.46% 95.89%
CHEMBL5261 Q7L7X3 Serine/threonine-protein kinase TAO1 85.05% 89.33%
CHEMBL3267 P48736 PI3-kinase p110-gamma subunit 84.83% 95.71%
CHEMBL2111367 P27986 PI3-kinase p110-alpha/p85-alpha 84.82% 94.33%
CHEMBL3018 Q9Y5Y6 Matriptase 84.51% 98.33%
CHEMBL5251 Q06187 Tyrosine-protein kinase BTK 84.23% 98.51%
CHEMBL4618 P09960 Leukotriene A4 hydrolase 84.21% 97.86%
CHEMBL344 Q99705 Melanin-concentrating hormone receptor 1 83.73% 92.50%
CHEMBL4822 P56817 Beta-secretase 1 83.63% 97.35%
CHEMBL4816 Q9Y243 Serine/threonine-protein kinase AKT3 83.59% 96.28%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 83.51% 97.14%
CHEMBL3430907 Q96GD4 Aurora kinase B/Inner centromere protein 83.08% 97.50%
CHEMBL2803 P43403 Tyrosine-protein kinase ZAP-70 82.72% 82.50%
CHEMBL4330 Q9NS75 Cysteinyl leukotriene receptor 2 82.69% 98.00%
CHEMBL3892 Q99500 Sphingosine 1-phosphate receptor Edg-3 82.60% 97.29%
CHEMBL3286 P00749 Urokinase-type plasminogen activator 82.16% 97.88%
CHEMBL333 P08253 Matrix metalloproteinase-2 81.02% 96.31%
CHEMBL5852 Q96P65 Pyroglutamylated RFamide peptide receptor 80.30% 85.00%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 80.28% 97.64%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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Cross-Links

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PubChem 101599802
LOTUS LTS0201058
wikiData Q105180108