Cyclo-(L-Pro-L-Tyr-L-Pro-Val-)

Details

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Internal ID df123c7a-80b2-4b1c-b80f-e5c9e30c9cc6
Taxonomy Organic acids and derivatives > Carboxylic acids and derivatives > Amino acids, peptides, and analogues > Peptides > Cyclic peptides
IUPAC Name (3S,6S,12S,15S)-3-[(4-hydroxyphenyl)methyl]-12-propan-2-yl-1,4,10,13-tetrazatricyclo[13.3.0.06,10]octadecane-2,5,11,14-tetrone
SMILES (Canonical) CC(C)C1C(=O)N2CCCC2C(=O)NC(C(=O)N3CCCC3C(=O)N1)CC4=CC=C(C=C4)O
SMILES (Isomeric) CC(C)[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CC=C(C=C4)O
InChI InChI=1S/C24H32N4O5/c1-14(2)20-24(33)28-12-4-5-18(28)21(30)25-17(13-15-7-9-16(29)10-8-15)23(32)27-11-3-6-19(27)22(31)26-20/h7-10,14,17-20,29H,3-6,11-13H2,1-2H3,(H,25,30)(H,26,31)/t17-,18-,19-,20-/m0/s1
InChI Key HKYOVILVNXGWMH-MUGJNUQGSA-N
Popularity 4 references in papers

Physical and Chemical Properties

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Molecular Formula C24H32N4O5
Molecular Weight 456.50 g/mol
Exact Mass 456.23727013 g/mol
Topological Polar Surface Area (TPSA) 119.00 Ų
XlogP 1.80

Synonyms

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(3S,6S,12S,15S)-3-((4-hydroxyphenyl)methyl)-12-propan-2-yl-1,4,10,13-tetrazatricyclo(13.3.0.06,10)octadecane-2,5,11,14-tetrone
(3S,6S,12S,15S)-3-[(4-hydroxyphenyl)methyl]-12-propan-2-yl-1,4,10,13-tetrazatricyclo[13.3.0.06,10]octadecane-2,5,11,14-tetrone
RefChem:1082412
cyclo(prolyltyrosylprolylvalyl)
CHEMBL5429559
CHEBI:219575

2D Structure

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2D Structure of Cyclo-(L-Pro-L-Tyr-L-Pro-Val-)

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 99.64% 98.95%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 98.07% 96.09%
CHEMBL5103 Q969S8 Histone deacetylase 10 97.21% 90.08%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 97.19% 94.45%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 95.97% 85.14%
CHEMBL5608 Q16288 NT-3 growth factor receptor 94.81% 95.89%
CHEMBL3137262 O60341 LSD1/CoREST complex 92.66% 97.09%
CHEMBL5966 P55899 IgG receptor FcRn large subunit p51 92.50% 90.93%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 90.90% 95.56%
CHEMBL3524 P56524 Histone deacetylase 4 90.32% 92.97%
CHEMBL2069156 Q14145 Kelch-like ECH-associated protein 1 90.23% 82.38%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 88.46% 90.71%
CHEMBL253 P34972 Cannabinoid CB2 receptor 88.41% 97.25%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 87.61% 91.11%
CHEMBL1902 P62942 FK506-binding protein 1A 86.62% 97.05%
CHEMBL5203 P33316 dUTP pyrophosphatase 85.24% 99.18%
CHEMBL2274 Q9H228 Sphingosine 1-phosphate receptor Edg-8 84.79% 100.00%
CHEMBL3310 Q96DB2 Histone deacetylase 11 84.62% 88.56%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 84.33% 97.64%
CHEMBL1907603 Q05586 Glutamate NMDA receptor; GRIN1/GRIN2B 83.41% 95.89%
CHEMBL5896 O75164 Lysine-specific demethylase 4A 82.79% 99.09%
CHEMBL4616 Q92847 Ghrelin receptor 82.65% 92.00%
CHEMBL6175 Q9H3R0 Lysine-specific demethylase 4C 81.86% 96.69%
CHEMBL1978 P11511 Cytochrome P450 19A1 81.42% 91.76%
CHEMBL5697 Q9GZT9 Egl nine homolog 1 81.13% 93.40%
CHEMBL1937 Q92769 Histone deacetylase 2 80.78% 94.75%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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There are no matching plants.

Cross-Links

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PubChem 10027074
LOTUS LTS0079051
wikiData Q76414986