Chaetochalasin A

Details

Top
Internal ID 34541af1-d9c1-4642-819d-58b974285b37
Taxonomy Organoheterocyclic compounds > Isoindoles and derivatives > Isoindolines > Isoindolones
IUPAC Name (1S,2S,5R,6R,7S,10S,12S,15S,16R,18S,20S)-4,5,16,18,20-pentamethyl-7-propan-2-yl-8-azapentacyclo[10.8.0.02,10.06,10.015,20]icosa-3,13-diene-9,11-dione
SMILES (Canonical) CC1CC(C2C=CC3C(C2(C1)C)C4C=C(C(C5C4(C3=O)C(=O)NC5C(C)C)C)C)C
SMILES (Isomeric) C[C@H]1C[C@H]([C@H]2C=C[C@H]3[C@@H]([C@]2(C1)C)[C@@H]4C=C([C@@H]([C@@H]5[C@@]4(C3=O)C(=O)N[C@H]5C(C)C)C)C)C
InChI InChI=1S/C27H39NO2/c1-13(2)23-21-17(6)15(4)11-20-22-18(24(29)27(20,21)25(30)28-23)8-9-19-16(5)10-14(3)12-26(19,22)7/h8-9,11,13-14,16-23H,10,12H2,1-7H3,(H,28,30)/t14-,16+,17-,18-,19+,20-,21-,22+,23-,26-,27-/m0/s1
InChI Key MYAIFNPIHQINJU-WSBLIIRGSA-N
Popularity 1 reference in papers

Physical and Chemical Properties

Top
Molecular Formula C27H39NO2
Molecular Weight 409.60 g/mol
Exact Mass 409.298079487 g/mol
Topological Polar Surface Area (TPSA) 46.20 Ų
XlogP 5.70

Synonyms

Top
(1S,2S,5R,6R,7S,10S,12S,15S,16R,18S,20S)-4,5,16,18,20-Pentamethyl-7-propan-2-yl-8-azapentacyclo[10.8.0.02,10.06,10.015,20]icosa-3,13-diene-9,11-dione

2D Structure

Top
2D Structure of Chaetochalasin A

3D Structure

Top

ADMET Properties (via admetSAR 2)

Top
Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

Top

Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL1937 Q92769 Histone deacetylase 2 94.63% 94.75%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 94.59% 96.09%
CHEMBL253 P34972 Cannabinoid CB2 receptor 94.06% 97.25%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 91.46% 91.11%
CHEMBL2581 P07339 Cathepsin D 90.83% 98.95%
CHEMBL3137262 O60341 LSD1/CoREST complex 90.61% 97.09%
CHEMBL230 P35354 Cyclooxygenase-2 90.31% 89.63%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 89.91% 95.56%
CHEMBL4026 P40763 Signal transducer and activator of transcription 3 87.72% 82.69%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 87.25% 94.45%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 86.85% 85.14%
CHEMBL2996 Q05655 Protein kinase C delta 85.26% 97.79%
CHEMBL5103 Q969S8 Histone deacetylase 10 84.50% 90.08%
CHEMBL4803 P29474 Nitric-oxide synthase, endothelial 83.96% 86.00%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 83.83% 90.71%
CHEMBL3038477 P67870 Casein kinase II alpha/beta 83.70% 99.23%
CHEMBL5697 Q9GZT9 Egl nine homolog 1 83.50% 93.40%
CHEMBL3359 P21462 Formyl peptide receptor 1 81.54% 93.56%
CHEMBL4227 P25090 Lipoxin A4 receptor 81.53% 100.00%
CHEMBL4303 P08238 Heat shock protein HSP 90-beta 81.34% 96.77%
CHEMBL1994 P08235 Mineralocorticoid receptor 81.18% 100.00%
CHEMBL5608 Q16288 NT-3 growth factor receptor 80.29% 95.89%

Plants that contains it

Top
Below are displayed all the plants proven (via scientific papers) to contain this compound!
To see more specific details click the taxa you are interested in.
There are no matching plants.

Cross-Links

Top
PubChem 10431661
LOTUS LTS0062847
wikiData Q105174743