Cefpodoxime Proxetil

Details

• Internal ID: 62ddc006-1385-4ab1-b8b6-1c8789582c18
• Taxonomy: Organoheterocyclic compounds > Lactams > Beta lactams > Cephalosporins
• IUPAC Name: 1-propan-2-yloxycarbonyloxyethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1
• InChI Key: LTINZAODLRIQIX-FBXRGJNPSA-N
• Popularity: 216 references in papers

Physical and Chemical Properties

• Molecular Formula: C₂₁H₂₇N₅O₉S₂
• Molecular Weight: 557.60 g/mol
• Exact Mass: 557.12501980 g/mol
• Topological Polar Surface Area (TPSA): 235.00 Ų
• XlogP: 0.60

Synonyms

• Vantin
• Banan
• 87239-81-4
• Cefodox
• Doxef
• Orelox
• CS-807
• Simplicef
• Otreon
• Podomexef
• U-76252
• Xtum-O
• CHEBI:3505
• UNII-2TB00A1Z7N
• 2TB00A1Z7N
• DTXSID1022766
• CPDX-PR
• Simplicef [Veterinary]
• NSC-759161
• DTXCID802766
• CEFPODOXIME (AS PROXETIL)
• cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl ester
• Cefpodoxime proxetil [USAN:USP:JAN]
• NSC 759161
• (RS)-1-((Isopropoxycarbonyl)oxy)ethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)-2-((Z)-methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
• Simplicef (Veterinary)
• CEFPODOXIME 1-(ISOPROPOXYCARBONYLOXY)ETHYL ESTER
• CEFPODOXIME PROXETIL (MART.)
• CEFPODOXIME PROXETIL [MART.]
• CEFPODOXIME PROXETIL (USP-RS)
• CEFPODOXIME PROXETIL [USP-RS]
• Cefpodoxime proxetil (USAN:USP:JAN)
• 947692-13-9
• 1-{[(propan-2-yloxy)carbonyl]oxy}ethyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 1-{[(propan-2-yloxy)carbonyl]oxy}ethyl 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-3,4-didehydrocepham-4-carboxylate
• CEFPODOXIME PROXETIL (EP MONOGRAPH)
• CEFPODOXIME PROXETIL (USP IMPURITY)
• CEFPODOXIME PROXETIL [EP MONOGRAPH]
• CEFPODOXIME PROXETIL [USP IMPURITY]
• CAS-87239-81-4
• CEFPODOXIME PROXETIL (USP MONOGRAPH)
• CEFPODOXIME PROXETIL [USP MONOGRAPH]
• Cefpoderm
• Orelox Paed
• NCGC00164598-01
• NCGC00183131-01
• MFCD00865088
• Vantin (TN)
• SCHEMBL27071
• MLS001401428
• Cefpodoxime Proxetil Impurity D
• CHEMBL1201016
• Cefpodoxime proxetil (JP17/USP)
• CEFPODOXIME PROXETIL [JAN]
• HMS3715J22
• CEFPODOXIME PROXETIL [USAN]
• 1-((Isopropoxycarbonyl)oxy)ethyl (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CEFPODOXIME PROXETIL, VANTIN
• HY-N7101
• CEFPODOXIME PROXETIL [VANDF]
• Tox21_113377
• Tox21_113428
• BDBM50248233
• s5350
• CEFPODOXIME PROXETIL [WHO-DD]
• AKOS015994692
• CCG-221250
• KS-1149
• CEFPODOXIME PROXETIL [GREEN BOOK]
• (+-)-1-Hydroxyethyl (+)-(6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate, 7(sup 2)-(Z)-(O-methyloxime), isopropyl carbonate (ester)
• CEFPODOXIME PROXETIL [ORANGE BOOK]
• RU-51807
• SMR000469193
• Cefpodoxime proxetil for peak identification
• CS-0027614
• C08115
• D00920
• AB01209734-01
• A842048
• Cefpodoxime proxetil for impurity H identification
• CEFPODOXIME 1-(ISOPROPOXYCARBONYLOXY)ETHYL ESTER [MI]
• (+/-)-1-HYDROXYETHYL (+)-(6R,7R)-7-(2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO)-3-(METHOXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLATE, 7 (SUP 2)-(Z)-(O-METHYLOXIME), ISOPROPYL CARBONATE (ESTER)
• (6R,7R)-1-((Isopropoxycarbonyl)oxy)ethyl 7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• (6R,7R)-7-(((2Z)-2-(2-AMINO-4-THIAZOLYL)-2-(METHOXYIMINO)ACETYL)AMINO)-3-(METHOXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID 1-(((1-METHYLETHOXY)CARBONYL)OXY)ETHYL ESTER
• 1-({[(1-methylethyl)oxy]carbonyl}oxy)ethyl (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• 5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-(((2-AMINO-4-THIAZOLYL)(METHOXYIMINO)ACETYL)AMINO)-3-(METHOXYMETHYL)-8-OXO-, 1-(((1-METHYLETHOXY)CARBONYL)OXY)ETHYL ESTER, (6R-(6.ALPHA.,7.BETA.(Z)))-
• 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, 1-(((1-methylethoxy)carbonyl)oxy)ethyl ester, (6R-(6alpha,7beta(Z)))-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
No predicted properties yet!

Targets

Proven Targets:

No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	99.18%	96.09%
CHEMBL4261	Q16665	Hypoxia-inducible factor 1 alpha	91.91%	85.14%
CHEMBL4203	Q9HAZ1	Dual specificity protein kinase CLK4	91.70%	94.45%
CHEMBL5845	P23415	Glycine receptor subunit alpha-1	91.25%	90.71%
CHEMBL3038477	P67870	Casein kinase II alpha/beta	90.29%	99.23%
CHEMBL2581	P07339	Cathepsin D	89.77%	98.95%
CHEMBL2107	P61073	C-X-C chemokine receptor type 4	88.56%	93.10%
CHEMBL3060	Q9Y345	Glycine transporter 2	85.50%	99.17%
CHEMBL1907603	Q05586	Glutamate NMDA receptor; GRIN1/GRIN2B	82.84%	95.89%
CHEMBL225	P28335	Serotonin 2c (5-HT2c) receptor	82.36%	89.62%
CHEMBL3137262	O60341	LSD1/CoREST complex	81.59%	97.09%
CHEMBL340	P08684	Cytochrome P450 3A4	81.25%	91.19%
CHEMBL4208	P20618	Proteasome component C5	81.13%	90.00%
CHEMBL3807	P17706	T-cell protein-tyrosine phosphatase	80.97%	93.00%
CHEMBL3401	O75469	Pregnane X receptor	80.75%	94.73%
CHEMBL5619	P27695	DNA-(apurinic or apyrimidinic site) lyase	80.10%	91.11%

Plants that contains it

There are no matching plants.

Cross-Links

• PubChem: 6526396
• LOTUS: LTS0185225
• wikiData: Q1052672