Antibiotic AM-2282;STS;AM-2282

Details

• Internal ID: 05f732a1-792c-4a62-9fc5-cfa7c194a9d9
• Taxonomy: Organoheterocyclic compounds > Indoles and derivatives > Carbazoles > Pyrrolocarbazoles > Indolocarbazoles
• IUPAC Name: (2S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
• InChI: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17?,20?,26?,28-/m0/s1
• InChI Key: HKSZLNNOFSGOKW-ZYSRIHRCSA-N
• Popularity: 3 references in papers

Physical and Chemical Properties

• Molecular Formula: C₂₈H₂₆N₄O₃
• Molecular Weight: 466.50 g/mol
• Exact Mass: 466.20049070 g/mol
• Topological Polar Surface Area (TPSA): 69.50 Ų
• XlogP: 3.20

Synonyms

• Antibiotic AM-2282;STS;AM-2282
• Kinome_3629
• SCHEMBL13168061
• A858151

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
No predicted properties yet!

Targets

Proven Targets:

CHEMBL ID	UniProt ID	Name	Min activity	Assay type	Source
CHEMBL2534	O15530	3-phosphoinositide dependent protein kinase-1	1.7 nM	Kd	via Super-PRED
CHEMBL5903	Q04771	Activin receptor type-1	470 nM	Kd	via Super-PRED
CHEMBL5310	P36896	Activin receptor type-1B	680 nM	Kd	via Super-PRED
CHEMBL3830	Q2M2I8	Adaptor-associated kinase	1.2 nM	Kd	via Super-PRED
CHEMBL4247	Q9UM73	ALK tyrosine kinase receptor	0.67 nM	IC50	via Super-PRED
CHEMBL4045	Q13131	AMP-activated protein kinase, alpha-1 subunit	3.7 nM	Kd	via Super-PRED
CHEMBL2116	P54646	AMP-activated protein kinase, alpha-2 subunit	12 nM	Kd	via Super-PRED
CHEMBL5547	Q8NFD2	Ankyrin repeat and protein kinase domain-containing protein 1	270 nM	Kd	via Super-PRED
CHEMBL2096618	P11274	Bcr/Abl fusion protein	121.8 nM	IC50	via Super-PRED
CHEMBL1075166	P35626	Beta-adrenergic receptor kinase 2	850 nM	IC50	via Super-PRED
CHEMBL4522	Q9NSY1	BMP-2-inducible protein kinase	3.7 nM	Kd	via Super-PRED
CHEMBL5650	Q8TDC3	BR serine/threonine-protein kinase 1	0.856 nM	IC50	via Super-PRED
CHEMBL4574	Q8IWQ3	BR serine/threonine-protein kinase 2	2.33 nM	IC50	via Super-PRED
CHEMBL2276	P45983	c-Jun N-terminal kinase 1	220 nM	Kd	via Super-PRED
CHEMBL2637	P53779	c-Jun N-terminal kinase 3	110 nM	Kd	via Super-PRED
CHEMBL3627592	Q6P2M8	Calcium/calmodulin-dependent protein kinase type 1B	4.99 nM	IC50	via Super-PRED
CHEMBL2493	Q14012	CaM kinase I alpha	3.02 nM	IC50	via Super-PRED
CHEMBL5073	Q8IU85	CaM kinase I delta	0.298 nM	IC50	via Super-PRED
CHEMBL5258	Q96NX5	CaM kinase I gamma	5.34 nM	IC50	via Super-PRED
CHEMBL4147	Q9UQM7	CaM kinase II alpha	0.0635 nM	IC50	via Super-PRED
CHEMBL4121	Q13554	CaM kinase II beta	0.07 nM	IC50	via Super-PRED
CHEMBL2801	Q13557	CaM kinase II delta	0.0311 nM	IC50	via Super-PRED
CHEMBL3829	Q13555	CaM kinase II gamma	0.387 nM	IC50	via Super-PRED
CHEMBL2494	Q16566	CaM kinase IV	41 nM	Kd	via Super-PRED
CHEMBL5256	Q8N5S9	CaM-kinase kinase alpha	0.039 nM	Kd	via Super-PRED
CHEMBL5284	Q96RR4	CaM-kinase kinase beta	0.05 nM	Kd	via Super-PRED
CHEMBL4101	P17612	cAMP-dependent protein kinase alpha-catalytic subunit	0.935 nM	IC50	via Super-PRED
CHEMBL2918	P22694	cAMP-dependent protein kinase beta-1 catalytic subunit	1.2 nM	IC50	via Super-PRED
CHEMBL2743	P22612	cAMP-dependent protein kinase, gamma catalytic subunit	6.8 nM	IC50	via Super-PRED
CHEMBL4937	P49674	Casein kinase I epsilon	73 nM	Kd	via Super-PRED
CHEMBL2543	P78368	Casein kinase I gamma 2	780 nM	Kd	via Super-PRED
CHEMBL5520	Q8N752	Casein kinase I isoform alpha-like	250 nM	Kd	via Super-PRED
CHEMBL3629	P68400	Casein kinase II alpha	36 nM	Kd	via Super-PRED
CHEMBL4070	P19784	Casein kinase II alpha (prime)	6.5 nM	Kd	via Super-PRED
CHEMBL2111377	Q9UBU7	CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)	46.3 nM	IC50	via Super-PRED
CHEMBL3038467	P06493	CDK1/Cyclin A	1.7 nM	IC50	via Super-PRED
CHEMBL3038468	P06493	CDK1/Cyclin E	2.17 nM	IC50	via Super-PRED
CHEMBL4106169	O75909	CDK12/Cyclin K	53 nM	IC50	via Super-PRED
CHEMBL4523637	Q00537	CDK17/Cyclin-Y	16.3 nM	IC50	via Super-PRED
CHEMBL4106161	Q07002	CDK18/Cyclin Y	51.1 nM	IC50	via Super-PRED
CHEMBL3038469	P24941	CDK2/Cyclin A	0.4 nM	IC50	via Super-PRED
CHEMBL3038470	P24941	CDK2/Cyclin A1	0.5 nM	IC50	via Super-PRED
CHEMBL4106152	P24941	CDK2/Cyclin O	1.46 nM	IC50	via Super-PRED
CHEMBL3038471	P24864	CDK3/Cyclin E	2.08 nM	IC50	via Super-PRED
CHEMBL3038472	P11802	CDK4/Cyclin D3	37.1 nM	IC50	via Super-PRED
CHEMBL2111455	P24385	CDK6/cyclin D1	2.9 nM	IC50	via Super-PRED
CHEMBL2111448	P30281	CDK6/cyclin D3	15.4 nM	IC50	via Super-PRED
CHEMBL3038473	P51946	CDK7/Cyclin H/MNAT1	76.6 nM	IC50	via Super-PRED
CHEMBL3038474	P49336	CDK8/Cyclin C	6 nM	IC50	via Super-PRED
CHEMBL3038475	P50750	CDK9/Cyclin K	13 nM	IC50	via Super-PRED
CHEMBL2111389	O60563	CDK9/cyclin T1	7 nM	Ki	via Super-PRED
CHEMBL4523631	P50750	CDK9/Cyclin-T2	3.77 nM	IC50	via Super-PRED
CHEMBL6002	Q9BWU1	Cell division cycle 2-like protein kinase 6	190 nM	Kd	via Super-PRED
CHEMBL5719	P49336	Cell division protein kinase 8	510 nM	Kd	via Super-PRED
CHEMBL4273	Q13976	cGMP-dependent protein kinase 1 beta	1.23 nM	IC50	via Super-PRED
CHEMBL2896	Q13237	cGMP-dependent protein kinase 2	5.77 nM	IC50	via Super-PRED
CHEMBL5579	O14578	Citron Rho-interacting kinase	340 nM	Kd	via Super-PRED
CHEMBL308	P06493	Cyclin-dependent kinase 1	0.4 nM	IC50	via Super-PRED
CHEMBL2094127	P06493	Cyclin-dependent kinase 1/cyclin B	2.52 nM	IC50	via Super-PRED
CHEMBL1907602	P06493	Cyclin-dependent kinase 1/cyclin B1	1.42 nM	IC50	via Super-PRED
CHEMBL4296067	Q14004	Cyclin-dependent kinase 13/Cyclin-K	57 nM	IC50	via Super-PRED
CHEMBL4296115	O94921	Cyclin-dependent kinase 14/Cyclin-Y	101 nM	IC50	via Super-PRED
CHEMBL301	P24941	Cyclin-dependent kinase 2	0.1 nM	IC50	via Super-PRED
CHEMBL2094128	P24941	Cyclin-dependent kinase 2/cyclin A	4 nM	Ki	via Super-PRED
CHEMBL2094126	P24864	Cyclin-dependent kinase 2/cyclin E	1 nM	IC50	via Super-PRED
CHEMBL1907605	P24864	Cyclin-dependent kinase 2/cyclin E1	1.67 nM	IC50	via Super-PRED
CHEMBL4442	Q00526	Cyclin-dependent kinase 3	30 nM	Kd	via Super-PRED
CHEMBL1907601	P11802	Cyclin-dependent kinase 4/cyclin D1	6.6 nM	IC50	via Super-PRED
CHEMBL4036	Q00535	Cyclin-dependent kinase 5	84 nM	Kd	via Super-PRED
CHEMBL1907600	Q00535	Cyclin-dependent kinase 5/CDK5 activator 1	1.2 nM	IC50	via Super-PRED
CHEMBL3055	P50613	Cyclin-dependent kinase 7	45 nM	Kd	via Super-PRED
CHEMBL2111288	P51946	Cyclin-dependent kinase 7/ cyclin H	910 nM	IC50	via Super-PRED
CHEMBL3116	P50750	Cyclin-dependent kinase 9	100 nM	Kd	via Super-PRED
CHEMBL3885550	Q00536	Cyclin-Y/Cyclin-dependent kinase 16	24 nM	IC50	via Super-PRED
CHEMBL2722	P19099	Cytochrome P450 11B2	11 nM	IC50	via Super-PRED
CHEMBL2558	P53355	Death-associated protein kinase 1	1.4 nM	Kd	via Super-PRED
CHEMBL3123	Q9UIK4	Death-associated protein kinase 2	1.6 nM	Kd	via Super-PRED
CHEMBL2468	O43293	Death-associated protein kinase 3	1 nM	Kd	via Super-PRED
CHEMBL5122	Q16832	Discoidin domain-containing receptor 2	1.19 nM	IC50	via Super-PRED
CHEMBL1908386	Q6XUX3	Dual serine/threonine and tyrosine protein kinase	65.2 nM	IC50	via Super-PRED
CHEMBL3587	Q02750	Dual specificity mitogen-activated protein kinase kinase 1	2.5 nM	IC50	via Super-PRED
CHEMBL2964	P36507	Dual specificity mitogen-activated protein kinase kinase 2	28 nM	Kd	via Super-PRED
CHEMBL2109	P46734	Dual specificity mitogen-activated protein kinase kinase 3	5 nM	Kd	via Super-PRED
CHEMBL2897	P45985	Dual specificity mitogen-activated protein kinase kinase 4	70 nM	Kd	via Super-PRED
CHEMBL4948	Q13163	Dual specificity mitogen-activated protein kinase kinase 5	40.4 nM	IC50	via Super-PRED
CHEMBL2171	P52564	Dual specificity mitogen-activated protein kinase kinase 6	3.4 nM	Kd	via Super-PRED
CHEMBL4225	P49760	Dual specificity protein kinase CLK2	5.52 nM	IC50	via Super-PRED
CHEMBL4226	P49761	Dual specificity protein kinase CLK3	910 nM	Kd	via Super-PRED
CHEMBL4203	Q9HAZ1	Dual specificity protein kinase CLK4	9.6 nM	Kd	via Super-PRED
CHEMBL3983	P33981	Dual specificity protein kinase TTK	61 nM	Kd	via Super-PRED
CHEMBL5604	Q15569	Dual specificity testis-specific protein kinase 1	261 nM	IC50	via Super-PRED
CHEMBL5543	Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.967 nM	IC50	via Super-PRED
CHEMBL4224	P49759	Dual specificty protein kinase CLK1	14.2 nM	IC50	via Super-PRED
CHEMBL2292	Q13627	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	4.93 nM	IC50	via Super-PRED
CHEMBL4376	Q92630	Dual-specificity tyrosine-phosphorylation regulated kinase 2	248 nM	IC50	via Super-PRED
CHEMBL4575	O43781	Dual-specificity tyrosine-phosphorylation regulated kinase 3	34.8 nM	IC50	via Super-PRED
CHEMBL5810	P21709	Ephrin type-A receptor 1	49.8 nM	IC50	via Super-PRED
CHEMBL2068	P29317	Ephrin type-A receptor 2	74.5 nM	IC50	via Super-PRED
CHEMBL4954	P29320	Ephrin type-A receptor 3	19.72 nM	IC50	via Super-PRED
CHEMBL3988	P54764	Ephrin type-A receptor 4	12.5 nM	IC50	via Super-PRED
CHEMBL3987	P54756	Ephrin type-A receptor 5	21.5 nM	IC50	via Super-PRED
CHEMBL4526	Q9UF33	Ephrin type-A receptor 6	11.8 nM	IC50	via Super-PRED
CHEMBL4602	Q15375	Ephrin type-A receptor 7	56.3 nM	IC50	via Super-PRED
CHEMBL4134	P29322	Ephrin type-A receptor 8	137 nM	IC50	via Super-PRED
CHEMBL5072	P54762	Ephrin type-B receptor 1	60.3 nM	IC50	via Super-PRED
CHEMBL3290	P29323	Ephrin type-B receptor 2	116 nM	IC50	via Super-PRED
CHEMBL5147	P54760	Ephrin type-B receptor 4	126.4 nM	IC50	via Super-PRED
CHEMBL5319	Q08345	Epithelial discoidin domain-containing receptor 1	4.28 nM	IC50	via Super-PRED
CHEMBL5358	Q9P2K8	Eukaryotic translation initiation factor 2-alpha kinase 4	16 nM	Kd	via Super-PRED
CHEMBL3650	P11362	Fibroblast growth factor receptor 1	3.89 nM	IC50	via Super-PRED
CHEMBL4142	P21802	Fibroblast growth factor receptor 2	1.77 nM	IC50	via Super-PRED
CHEMBL2742	P22607	Fibroblast growth factor receptor 3	9.25 nM	IC50	via Super-PRED
CHEMBL3973	P22455	Fibroblast growth factor receptor 4	107 nM	IC50	via Super-PRED
CHEMBL2695	Q05397	Focal adhesion kinase 1	11 nM	IC50	via Super-PRED
CHEMBL5861	P32298	G protein-coupled receptor kinase 4	113 nM	IC50	via Super-PRED
CHEMBL5678	P34947	G protein-coupled receptor kinase 5	73.3 nM	IC50	via Super-PRED
CHEMBL1075133	Q8WTQ7	G protein-coupled receptor kinase 7	5.96 nM	IC50	via Super-PRED
CHEMBL2850	P49840	Glycogen synthase kinase-3 alpha	2.4 nM	IC50	via Super-PRED
CHEMBL262	P49841	Glycogen synthase kinase-3 beta	2.62 nM	IC50	via Super-PRED
CHEMBL3717	P08581	Hepatocyte growth factor receptor	57 nM; 107.4 nM	IC50; IC50	via Super-PRED; via Super-PRED
CHEMBL3820	P35557	Hexokinase type IV	0.81 nM	IC50	via Super-PRED
CHEMBL4576	Q9H2X6	Homeodomain-interacting protein kinase 2	585 nM	IC50	via Super-PRED
CHEMBL4577	Q9H422	Homeodomain-interacting protein kinase 3	710 nM	IC50	via Super-PRED
CHEMBL1075167	Q8NE63	Homeodomain-interacting protein kinase 4	314 nM	IC50	via Super-PRED
CHEMBL3476	O15111	Inhibitor of nuclear factor kappa B kinase alpha subunit	39 nM	IC50	via Super-PRED
CHEMBL1991	O14920	Inhibitor of nuclear factor kappa B kinase beta subunit	0.9 nM	IC50	via Super-PRED
CHEMBL3529	Q14164	Inhibitor of nuclear factor kappa B kinase epsilon subunit	0.439 nM	IC50	via Super-PRED
CHEMBL1981	P06213	Insulin receptor	14.73 nM; 36.35 nM	IC50; IC50	via Super-PRED; via Super-PRED
CHEMBL5483	P14616	Insulin receptor-related protein	15 nM	IC50	via Super-PRED
CHEMBL1957	P08069	Insulin-like growth factor I receptor	43.3 nM; 71.53 nM	IC50; IC50	via Super-PRED; via Super-PRED
CHEMBL5785	P19525	Interferon-induced, double-stranded RNA-activated protein kinase	100 nM	IC50	via Super-PRED
CHEMBL3357	P51617	Interleukin-1 receptor-associated kinase 1	59.3 nM	IC50	via Super-PRED
CHEMBL5081	Q9Y616	Interleukin-1 receptor-associated kinase 3	13 nM	Kd	via Super-PRED
CHEMBL3778	Q9NWZ3	Interleukin-1 receptor-associated kinase 4	4.21 nM	IC50	via Super-PRED
CHEMBL1075104	Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2	1 nM	IC50	via Super-PRED
CHEMBL5627	P29376	Leukocyte tyrosine kinase receptor	3.6 nM	IC50	via Super-PRED
CHEMBL3836	P53667	LIM domain kinase 1	2.44 nM	IC50	via Super-PRED
CHEMBL5932	P53671	LIM domain kinase 2	102 nM	IC50	via Super-PRED
CHEMBL5575	Q15046	Lysyl-tRNA synthetase	0.86 nM	IC50	via Super-PRED
CHEMBL1844	P07333	Macrophage colony stimulating factor receptor	1.14 nM	IC50	via Super-PRED
CHEMBL2689	Q04912	Macrophage-stimulating protein receptor	102.7 nM	IC50	via Super-PRED
CHEMBL260	Q16539	MAP kinase p38 alpha	10.5 nM	IC50	via Super-PRED
CHEMBL2939	O15264	MAP kinase p38 delta	160 nM	IC50	via Super-PRED
CHEMBL4674	P53778	MAP kinase p38 gamma	42 nM	Kd	via Super-PRED
CHEMBL4204	Q9HBH9	MAP kinase signal-integrating kinase 2	17 nM	Kd	via Super-PRED
CHEMBL2208	P49137	MAP kinase-activated protein kinase 2	110 nM	IC50	via Super-PRED
CHEMBL3094	Q8IW41	MAP kinase-activated protein kinase 5	295 nM	IC50	via Super-PRED
CHEMBL4718	Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase MNK1	52.7 nM	IC50	via Super-PRED
CHEMBL3831	Q7KZI7	MAP/microtubule affinity-regulating kinase 2	0.1 nM	Kd	via Super-PRED
CHEMBL5754	Q96L34	MAP/microtubule affinity-regulating kinase 4	0.114 nM	IC50	via Super-PRED
CHEMBL4578	Q14680	Maternal embryonic leucine zipper kinase	0.542 nM	IC50	via Super-PRED
CHEMBL5518	Q8N4C8	Misshapen-like kinase 1	0.451 nM	IC50	via Super-PRED
CHEMBL5198	Q8TD08	Mitogen-activated protein kinase 15	7.3 nM	IC50	via Super-PRED
CHEMBL5332	Q13164	Mitogen-activated protein kinase 7	121.6 nM	IC50	via Super-PRED
CHEMBL3956	Q13233	Mitogen-activated protein kinase kinase kinase 1	485 nM	IC50	via Super-PRED
CHEMBL2873	Q02779	Mitogen-activated protein kinase kinase kinase 10	2.69 nM	IC50	via Super-PRED
CHEMBL2708	Q16584	Mitogen-activated protein kinase kinase kinase 11	4 nM	IC50	via Super-PRED
CHEMBL1908389	Q12852	Mitogen-activated protein kinase kinase kinase 12	180 nM	IC50	via Super-PRED
CHEMBL5914	Q9Y2U5	Mitogen-activated protein kinase kinase kinase 2	43.5 nM	IC50	via Super-PRED
CHEMBL5970	Q99759	Mitogen-activated protein kinase kinase kinase 3	10.9 nM	IC50	via Super-PRED
CHEMBL5285	Q99683	Mitogen-activated protein kinase kinase kinase 5	0.69 nM	IC50	via Super-PRED
CHEMBL1163123	O95382	Mitogen-activated protein kinase kinase kinase 6	475 nM	IC50	via Super-PRED
CHEMBL5776	O43318	Mitogen-activated protein kinase kinase kinase 7	43.11 nM	IC50	via Super-PRED
CHEMBL2872	P80192	Mitogen-activated protein kinase kinase kinase 9	1.52 nM	IC50	via Super-PRED
CHEMBL5749	Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	4.3 nM	Kd	via Super-PRED
CHEMBL5432	Q8IVH8	Mitogen-activated protein kinase kinase kinase kinase 3	0.0825 nM	IC50	via Super-PRED
CHEMBL6166	O95819	Mitogen-activated protein kinase kinase kinase kinase 4	0.57 nM	IC50	via Super-PRED
CHEMBL4852	Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	0.309 nM	IC50	via Super-PRED
CHEMBL5684	O15146	Muscle, skeletal receptor tyrosine protein kinase	3.8 nM	IC50	via Super-PRED
CHEMBL5546	Q8NEV4	Myosin IIIA	44.8 nM	IC50	via Super-PRED
CHEMBL4627	Q32MK0	Myosin light chain kinase	129 nM	IC50	via Super-PRED
CHEMBL2777	Q9H1R3	myosin light chain kinase 2	13.9 nM	IC50	via Super-PRED
CHEMBL5426	Q86YV6	Myosin light chain kinase family member 4	52.9 nM	IC50	via Super-PRED
CHEMBL3062	P11799	Myosin light chain kinase, smooth muscle	140 nM	Kd	via Super-PRED
CHEMBL2428	Q15746	Myosin light chain kinase, smooth muscle	15 nM	Kd	via Super-PRED
CHEMBL5654	Q8WXR4	Myosin-IIIB	6.4 nM	IC50	via Super-PRED
CHEMBL5320	Q09013	Myotonin-protein kinase	3.5 nM	Kd	via Super-PRED
CHEMBL2815	P04629	Nerve growth factor receptor Trk-A	0.5 nM	IC50	via Super-PRED
CHEMBL4898	Q16620	Neurotrophic tyrosine kinase receptor type 2	0.0636 nM	IC50	via Super-PRED
CHEMBL1293277	O15118	Niemann-Pick C1 protein	501.2 nM	Potency	via Super-PRED
CHEMBL5334	Q13470	Non-receptor tyrosine-protein kinase TNK1	0.584 nM	IC50	via Super-PRED
CHEMBL5608	Q16288	NT-3 growth factor receptor	0.22 nM	IC50	via Super-PRED
CHEMBL5784	O60285	NUAK family SNF1-like kinase 1	1.31 nM	IC50	via Super-PRED
CHEMBL5698	Q9H093	NUAK family SNF1-like kinase 2	0.086 nM	Kd	via Super-PRED
CHEMBL6054	Q96RG2	PAS domain-containing serine/threonine-protein kinase	15.8 nM	IC50	via Super-PRED
CHEMBL4896	Q96KB5	PDZ-binding kinase	83.9 nM	IC50	via Super-PRED
CHEMBL5969	Q99755	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha	43 nM	Kd	via Super-PRED
CHEMBL5667	P78356	Phosphatidylinositol-5-phosphate 4-kinase type-2 beta	77 nM	Kd	via Super-PRED
CHEMBL4004	Q16816	Phosphorylase kinase gamma subunit 1	0.5 nM	Kd	via Super-PRED
CHEMBL2349	P15735	Phosphorylase kinase gamma subunit 2	0.14 nM	Kd	via Super-PRED
CHEMBL2007	P16234	Platelet-derived growth factor receptor alpha	0.43 nM	IC50	via Super-PRED
CHEMBL1913	P09619	Platelet-derived growth factor receptor beta	0.6 nM	IC50	via Super-PRED
CHEMBL299	P17252	Protein kinase C alpha	0.37 nM	IC50	via Super-PRED
CHEMBL3045	P05771	Protein kinase C beta	1.44 nM	IC50	via Super-PRED
CHEMBL2996	Q05655	Protein kinase C delta	0.128 nM	IC50	via Super-PRED
CHEMBL3582	Q02156	Protein kinase C epsilon	0.198 nM	IC50	via Super-PRED
CHEMBL3616	P24723	Protein kinase C eta	0.251 nM	IC50	via Super-PRED
CHEMBL2938	P05129	Protein kinase C gamma	1.43 nM	IC50	via Super-PRED
CHEMBL2598	P41743	Protein kinase C iota	31.6 nM	IC50	via Super-PRED
CHEMBL3863	Q15139	Protein kinase C mu	3.6 nM	IC50	via Super-PRED
CHEMBL2595	O94806	Protein kinase C nu	1.52 nM	IC50	via Super-PRED
CHEMBL3920	Q04759	Protein kinase C theta	1.44 nM	IC50	via Super-PRED
CHEMBL3438	Q05513	Protein kinase C zeta	76.8 nM	IC50	via Super-PRED
CHEMBL3384	Q16512	Protein kinase N1	1 nM	IC50	via Super-PRED
CHEMBL3032	Q16513	Protein kinase N2	1.97 nM	IC50	via Super-PRED
CHEMBL4523406	Q8TAX0	Protein odd-skipped-related 1	61.3 nM	IC50	via Super-PRED
CHEMBL5469	Q14289	Protein tyrosine kinase 2 beta	3.5 nM	Kd	via Super-PRED
CHEMBL5331	Q12866	Proto-oncogene tyrosine-protein kinase MER	6.4 nM	Kd	via Super-PRED
CHEMBL5568	P08922	Proto-oncogene tyrosine-protein kinase ROS	0.149 nM	IC50	via Super-PRED
CHEMBL3627585	Q9H792	Pseudopodium-enriched atypical kinase 1	3.04 nM	IC50	via Super-PRED
CHEMBL4766	Q15118	Pyruvate dehydrogenase kinase isoform 1	0.506 nM	IC50	via Super-PRED
CHEMBL1293294	P51151	Ras-related protein Rab-9A	316.2 nM	Potency	via Super-PRED
CHEMBL1824	P04626	Receptor protein-tyrosine kinase erbB-2	34 nM	IC50	via Super-PRED
CHEMBL3009	Q15303	Receptor protein-tyrosine kinase erbB-4	28.3 nM	IC50	via Super-PRED
CHEMBL5288	P06400	Retinoblastoma-associated protein	66 nM	IC50	via Super-PRED
CHEMBL3231	Q13464	Rho-associated protein kinase 1	0.64 nM	IC50	via Super-PRED
CHEMBL2973	O75116	Rho-associated protein kinase 2	0.933 nM	IC50	via Super-PRED
CHEMBL5607	Q15835	Rhodopsin kinase	57.8 nM	IC50	via Super-PRED
CHEMBL4501	P23443	Ribosomal protein S6 kinase 1	0.553 nM	IC50	via Super-PRED
CHEMBL3111	Q9UBS0	Ribosomal protein S6 kinase 2	2.35 nM	IC50	via Super-PRED
CHEMBL2553	Q15418	Ribosomal protein S6 kinase alpha 1	0.09 nM	IC50	via Super-PRED
CHEMBL3906	Q15349	Ribosomal protein S6 kinase alpha 2	0.227 nM	IC50	via Super-PRED
CHEMBL2345	P51812	Ribosomal protein S6 kinase alpha 3	0.124 nM	IC50	via Super-PRED
CHEMBL3125	O75676	Ribosomal protein S6 kinase alpha 4	11.3 nM	IC50	via Super-PRED
CHEMBL4237	O75582	Ribosomal protein S6 kinase alpha 5	1.4 nM	IC50	via Super-PRED
CHEMBL4924	Q9UK32	Ribosomal protein S6 kinase alpha 6	0.159 nM	IC50	via Super-PRED
CHEMBL5364	Q9UBE8	Serine/threonine protein kinase NLK	77.8 nM	IC50	via Super-PRED
CHEMBL3981	O94804	Serine/threonine-protein kinase 10	0.03 nM	Kd	via Super-PRED
CHEMBL5606	Q15831	Serine/threonine-protein kinase 11	61 nM	Kd	via Super-PRED
CHEMBL3938	O75716	Serine/threonine-protein kinase 16	200 nM	Kd	via Super-PRED
CHEMBL4525	Q9UEE5	Serine/threonine-protein kinase 17A	14 nM	Kd	via Super-PRED
CHEMBL3980	O94768	Serine/threonine-protein kinase 17B	21 nM	Kd	via Super-PRED
CHEMBL4202	Q9H2G2	Serine/threonine-protein kinase 2	0.02 nM	Kd	via Super-PRED
CHEMBL5082	Q9Y6E0	Serine/threonine-protein kinase 24	3.34 nM	IC50	via Super-PRED
CHEMBL5552	O00506	Serine/threonine-protein kinase 25	1.9 nM	IC50	via Super-PRED
CHEMBL5912	Q9NY57	Serine/threonine-protein kinase 32B	49.1 nM	IC50	via Super-PRED
CHEMBL5405	Q86UX6	Serine/threonine-protein kinase 32C	310 nM	Kd	via Super-PRED
CHEMBL6005	Q9BYT3	Serine/threonine-protein kinase 33	1.8 nM	Kd	via Super-PRED
CHEMBL1075155	Q15208	Serine/threonine-protein kinase 38	0.628 nM	IC50	via Super-PRED
CHEMBL4851	Q9Y2H1	Serine/threonine-protein kinase 38-like	1.47 nM	IC50	via Super-PRED
CHEMBL4282	P31749	Serine/threonine-protein kinase AKT	1.5 nM	IC50	via Super-PRED
CHEMBL2431	P31751	Serine/threonine-protein kinase AKT2	6.5 nM	IC50	via Super-PRED
CHEMBL4816	Q9Y243	Serine/threonine-protein kinase AKT3	5 nM	IC50	via Super-PRED
CHEMBL4722	O14965	Serine/threonine-protein kinase Aurora-A	0.86 nM	IC50	via Super-PRED
CHEMBL2185	Q96GD4	Serine/threonine-protein kinase Aurora-B	1 nM	IC50	via Super-PRED
CHEMBL3935	Q9UQB9	Serine/threonine-protein kinase Aurora-C	2.42 nM	IC50	via Super-PRED
CHEMBL5145	P15056	Serine/threonine-protein kinase B-raf	4.5 nM	IC50	via Super-PRED
CHEMBL5600	P27448	Serine/threonine-protein kinase c-TAK1	0.438 nM	IC50	via Super-PRED
CHEMBL4630	O14757	Serine/threonine-protein kinase Chk1	0.16 nM	IC50	via Super-PRED
CHEMBL2527	O96017	Serine/threonine-protein kinase Chk2	4.86 nM	IC50	via Super-PRED
CHEMBL4900	Q9BZL6	Serine/threonine-protein kinase D2	1.33 nM	IC50	via Super-PRED
CHEMBL5683	O15075	Serine/threonine-protein kinase DCLK1	110 nM	Kd	via Super-PRED
CHEMBL5519	Q8N568	Serine/threonine-protein kinase DCLK2	73 nM	Kd	via Super-PRED
CHEMBL6123	Q9C098	Serine/threonine-protein kinase DCLK3	17 nM	Kd	via Super-PRED
CHEMBL4355	O14976	Serine/threonine-protein kinase GAK	17 nM	Kd	via Super-PRED
CHEMBL1075163	Q8TF76	Serine/threonine-protein kinase haspin	19 nM	IC50	via Super-PRED
CHEMBL1163126	Q9UPZ9	Serine/threonine-protein kinase ICK	41.06 nM	IC50	via Super-PRED
CHEMBL6167	O95835	Serine/threonine-protein kinase LATS1	12.8 nM	IC50	via Super-PRED
CHEMBL5907	Q9NRM7	Serine/threonine-protein kinase LATS2	3.76 nM	IC50	via Super-PRED
CHEMBL4523432	Q96Q04	Serine/threonine-protein kinase LMTK3	0.002399 nM	IC50	via Super-PRED
CHEMBL1163106	P20794	Serine/threonine-protein kinase MAK	28.7 nM	IC50	via Super-PRED
CHEMBL5940	Q9P0L2	Serine/threonine-protein kinase MARK1	0.417 nM	IC50	via Super-PRED
CHEMBL5052	Q9Y5S2	Serine/threonine-protein kinase MRCK beta	4.75 nM	IC50	via Super-PRED
CHEMBL5615	Q6DT37	Serine/threonine-protein kinase MRCK gamma	0.848 nM	IC50	via Super-PRED
CHEMBL4516	Q5VT25	Serine/threonine-protein kinase MRCK-A	5.35 nM	IC50	via Super-PRED
CHEMBL4598	Q13043	Serine/threonine-protein kinase MST1	0.19 nM	Kd	via Super-PRED
CHEMBL4708	Q13188	Serine/threonine-protein kinase MST2	0.18 nM	Kd	via Super-PRED
CHEMBL5941	Q9P289	Serine/threonine-protein kinase MST4	2.87 nM	IC50	via Super-PRED
CHEMBL3627581	Q6P5Z2	Serine/threonine-protein kinase N3	13.2 nM	IC50	via Super-PRED
CHEMBL5855	Q96PY6	Serine/threonine-protein kinase Nek1	18.4 nM	IC50	via Super-PRED
CHEMBL5638	Q8NG66	Serine/threonine-protein kinase Nek11	752 nM	IC50	via Super-PRED
CHEMBL3835	P51955	Serine/threonine-protein kinase NEK2	345 nM	IC50	via Super-PRED
CHEMBL5819	P51957	Serine/threonine-protein kinase Nek4	96 nM	IC50	via Super-PRED
CHEMBL5044	Q6P3R8	Serine/threonine-protein kinase Nek5	96.5 nM	IC50	via Super-PRED
CHEMBL2417353	Q86SG6	Serine/threonine-protein kinase Nek8	17.5 nM	IC50	via Super-PRED
CHEMBL5257	Q8TD19	Serine/threonine-protein kinase NEK9	131 nM	IC50	via Super-PRED
CHEMBL3542	Q8IY84	Serine/threonine-protein kinase NIM1	129 nM	IC50	via Super-PRED
CHEMBL4600	Q13153	Serine/threonine-protein kinase PAK 1	0.3 nM	IC50	via Super-PRED
CHEMBL4487	Q13177	Serine/threonine-protein kinase PAK 2	2.59 nM	IC50	via Super-PRED
CHEMBL2999	O75914	Serine/threonine-protein kinase PAK 3	0.343 nM	IC50	via Super-PRED
CHEMBL4482	O96013	Serine/threonine-protein kinase PAK 4	1 nM	IC50	via Super-PRED
CHEMBL4311	Q9NQU5	Serine/threonine-protein kinase PAK6	0.4 nM	Kd	via Super-PRED
CHEMBL4524	Q9P286	Serine/threonine-protein kinase PAK7	1.2 nM	Kd	via Super-PRED
CHEMBL4597	Q00536	Serine/threonine-protein kinase PCTAIRE-1	24 nM	Kd	via Super-PRED
CHEMBL5790	Q00537	Serine/threonine-protein kinase PCTAIRE-2	96 nM	Kd	via Super-PRED
CHEMBL5316	Q07002	Serine/threonine-protein kinase PCTAIRE-3	270 nM	Kd	via Super-PRED
CHEMBL6162	O94921	Serine/threonine-protein kinase PFTAIRE-1	160 nM	Kd	via Super-PRED
CHEMBL2147	P11309	Serine/threonine-protein kinase PIM1	1.4 nM	Kd	via Super-PRED
CHEMBL4523	Q9P1W9	Serine/threonine-protein kinase PIM2	1.9 nM	Kd	via Super-PRED
CHEMBL5407	Q86V86	Serine/threonine-protein kinase PIM3	0.0885 nM	IC50	via Super-PRED
CHEMBL5938	Q9NYY3	Serine/threonine-protein kinase PLK2	365.9 nM	IC50	via Super-PRED
CHEMBL4897	Q9H4B4	Serine/threonine-protein kinase PLK3	224 nM	IC50	via Super-PRED
CHEMBL3788	O00444	Serine/threonine-protein kinase PLK4	0.75 nM	Kd	via Super-PRED
CHEMBL5818	P51817	Serine/threonine-protein kinase PRKX	1.39 nM	IC50	via Super-PRED
CHEMBL1906	P04049	Serine/threonine-protein kinase RAF	130 nM	IC50	via Super-PRED
CHEMBL5311	P37023	Serine/threonine-protein kinase receptor R3	850 nM	IC50	via Super-PRED
CHEMBL5975	Q9BRS2	Serine/threonine-protein kinase RIO1	130 nM	Kd	via Super-PRED
CHEMBL5659	O14730	Serine/threonine-protein kinase RIO3	76 nM	Kd	via Super-PRED
CHEMBL5014	O43353	Serine/threonine-protein kinase RIPK2	317 nM	IC50	via Super-PRED
CHEMBL1163129	Q52WX2	Serine/threonine-protein kinase SBK1	99.8 nM	IC50	via Super-PRED
CHEMBL2343	O00141	Serine/threonine-protein kinase Sgk1	6.75 nM	IC50	via Super-PRED
CHEMBL5794	Q9HBY8	Serine/threonine-protein kinase Sgk2	16.5 nM	IC50	via Super-PRED
CHEMBL6186	Q96BR1	Serine/threonine-protein kinase Sgk3	76.5 nM	IC50	via Super-PRED
CHEMBL6082	P57059	Serine/threonine-protein kinase SIK1	1.34 nM	IC50	via Super-PRED
CHEMBL5699	Q9H0K1	Serine/threonine-protein kinase SIK2	0.37 nM	IC50	via Super-PRED
CHEMBL6149	Q9Y2K2	Serine/threonine-protein kinase SIK3	1.24 nM	IC50	via Super-PRED
CHEMBL4375	Q96SB4	Serine/threonine-protein kinase SRPK1	5.5 nM	Kd	via Super-PRED
CHEMBL5668	P78362	Serine/threonine-protein kinase SRPK2	67 nM	Kd	via Super-PRED
CHEMBL5261	Q7L7X3	Serine/threonine-protein kinase TAO1	1.21 nM	IC50	via Super-PRED
CHEMBL1075195	Q9UL54	Serine/threonine-protein kinase TAO2	11.7 nM	IC50	via Super-PRED
CHEMBL5701	Q9H2K8	Serine/threonine-protein kinase TAO3	2.11 nM	IC50	via Super-PRED
CHEMBL5408	Q9UHD2	Serine/threonine-protein kinase TBK1	2.18 nM	IC50	via Super-PRED
CHEMBL5388	Q9UKI8	Serine/threonine-protein kinase tousled-like 1	21.7 nM	IC50	via Super-PRED
CHEMBL5404	Q86UE8	Serine/threonine-protein kinase tousled-like 2	3.66 nM	IC50	via Super-PRED
CHEMBL6006	O75385	Serine/threonine-protein kinase ULK1	8.95 nM	IC50	via Super-PRED
CHEMBL5435	Q8IYT8	Serine/threonine-protein kinase ULK2	2.67 nM	IC50	via Super-PRED
CHEMBL5047	Q6PHR2	Serine/threonine-protein kinase ULK3	4.2 nM	IC50	via Super-PRED
CHEMBL1163101	O75460	Serine/threonine-protein kinase/endoribonuclease IRE1	204 nM	IC50	via Super-PRED
CHEMBL4105932	Q76MJ5	Serine/threonine-protein kinase/endoribonuclease IRE2	65.8 nM	IC50	via Super-PRED
CHEMBL1908384	Q9NRH2	SNF-related serine/threonine-protein kinase	8.01 nM	IC50	via Super-PRED
CHEMBL4333	P21453	Sphingosine 1-phosphate receptor Edg-1	662 nM	IC50	via Super-PRED
CHEMBL3230	O95977	Sphingosine 1-phosphate receptor Edg-6	183 nM	IC50	via Super-PRED
CHEMBL6191	Q56UN5	SPS1/STE20-related protein kinase YSK4	15.6 nM	IC50	via Super-PRED
CHEMBL1163108	Q9UEW8	STE20/SPS1-related proline-alanine-rich protein kinase	14.4 nM	IC50	via Super-PRED
CHEMBL1936	P10721	Stem cell growth factor receptor	0.64 nM	Kd	via Super-PRED
CHEMBL1293232	Q16637	Survival motor neuron protein	794.3 nM	Potency	via Super-PRED
CHEMBL6003	Q9BXA7	Testis-specific serine/threonine-protein kinase 1	0.052 nM	IC50	via Super-PRED
CHEMBL6014	Q96PF2	Testis-specific serine/threonine-protein kinase 2	4.32 nM	IC50	via Super-PRED
CHEMBL3414416	Q96PN8	Testis-specific serine/threonine-protein kinase 3	7.01 nM	IC50	via Super-PRED
CHEMBL3627582	Q9BXA6	Testis-specific serine/threonine-protein kinase 6	193 nM	IC50	via Super-PRED
CHEMBL4527	Q9UKE5	TRAF2- and NCK-interacting kinase	0.551 nM	IC50	via Super-PRED
CHEMBL4139	P68370	Tubulin alpha-1 chain	770 nM	Kd	via Super-PRED
CHEMBL4599	Q07912	Tyrosine kinase non-receptor protein 2	16 nM	Kd	via Super-PRED
CHEMBL1862	P00519	Tyrosine-protein kinase ABL	27 nM	Kd	via Super-PRED
CHEMBL4014	P42684	Tyrosine-protein kinase ABL2	15.8 nM	IC50	via Super-PRED
CHEMBL2250	P51451	Tyrosine-protein kinase BLK	1.07 nM	IC50	via Super-PRED
CHEMBL3834	P51813	Tyrosine-protein kinase BMX	6.16 nM	IC50	via Super-PRED
CHEMBL4601	Q13882	Tyrosine-protein kinase BRK	247 nM	IC50	via Super-PRED
CHEMBL5251	Q06187	Tyrosine-protein kinase BTK	13.38 nM	IC50	via Super-PRED
CHEMBL2634	P41240	Tyrosine-protein kinase CSK	14.3 nM	IC50	via Super-PRED
CHEMBL4175	P42679	Tyrosine-protein kinase CTK	492 nM	IC50	via Super-PRED
CHEMBL3982	P16591	Tyrosine-protein kinase FER	0.365 nM	IC50	via Super-PRED
CHEMBL5455	P07332	Tyrosine-protein kinase FES	1.52 nM	IC50	via Super-PRED
CHEMBL4454	P09769	Tyrosine-protein kinase FGR	1.15 nM	IC50	via Super-PRED
CHEMBL4223	P42685	Tyrosine-protein kinase FRK	17 nM	IC50	via Super-PRED
CHEMBL1841	P06241	Tyrosine-protein kinase FYN	2.06 nM	IC50	via Super-PRED
CHEMBL3234	P08631	Tyrosine-protein kinase HCK	1.9 nM	IC50	via Super-PRED
CHEMBL2959	Q08881	Tyrosine-protein kinase ITK/TSK	4.02 nM	IC50	via Super-PRED
CHEMBL2835	P23458	Tyrosine-protein kinase JAK1	0.627 nM	IC50	via Super-PRED
CHEMBL2971	O60674	Tyrosine-protein kinase JAK2	0.189 nM	IC50	via Super-PRED
CHEMBL2148	P52333	Tyrosine-protein kinase JAK3	0.1 nM	IC50	via Super-PRED
CHEMBL258	P06239	Tyrosine-protein kinase LCK	1.01 nM	IC50	via Super-PRED
CHEMBL3905	P07948	Tyrosine-protein kinase Lyn	0.473 nM	IC50	via Super-PRED
CHEMBL1974	P36888	Tyrosine-protein kinase receptor FLT3	0.2 nM	IC50	via Super-PRED
CHEMBL2041	P07949	Tyrosine-protein kinase receptor RET	1.69 nM; 2.195 nM	IC50; IC50	via Super-PRED; via Super-PRED
CHEMBL5274	P35590	Tyrosine-protein kinase receptor Tie-1	65 nM	Kd	via Super-PRED
CHEMBL5314	Q06418	Tyrosine-protein kinase receptor TYRO3	2.75 nM	IC50	via Super-PRED
CHEMBL4895	P30530	Tyrosine-protein kinase receptor UFO	3 nM	IC50	via Super-PRED
CHEMBL267	P12931	Tyrosine-protein kinase SRC	2.2 nM	IC50	via Super-PRED
CHEMBL5703	Q9H3Y6	Tyrosine-protein kinase Srms	740 nM	Kd	via Super-PRED
CHEMBL2599	P43405	Tyrosine-protein kinase SYK	0.217 nM	IC50	via Super-PRED
CHEMBL4128	Q02763	Tyrosine-protein kinase TIE-2	50.9 nM	IC50	via Super-PRED
CHEMBL4367	P42681	Tyrosine-protein kinase TXK	21.6 nM	IC50	via Super-PRED
CHEMBL3553	P29597	Tyrosine-protein kinase TYK2	0.205 nM	IC50	via Super-PRED
CHEMBL2073	P07947	Tyrosine-protein kinase YES	2.35 nM	IC50	via Super-PRED
CHEMBL2803	P43403	Tyrosine-protein kinase ZAP-70	1.3 nM	IC50	via Super-PRED
CHEMBL1868	P17948	Vascular endothelial growth factor receptor 1	5.4 nM	IC50	via Super-PRED
CHEMBL279	P35968	Vascular endothelial growth factor receptor 2	1.2 nM; 115 nM	IC50; IC50	via Super-PRED; via Super-PRED
CHEMBL1955	P35916	Vascular endothelial growth factor receptor 3	0.9 nM	IC50	via Super-PRED

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL5619	P27695	DNA-(apurinic or apyrimidinic site) lyase	98.95%	91.11%
CHEMBL4261	Q16665	Hypoxia-inducible factor 1 alpha	98.19%	85.14%
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	97.39%	96.09%
CHEMBL3108638	O15164	Transcription intermediary factor 1-alpha	96.24%	95.56%
CHEMBL1806	P11388	DNA topoisomerase II alpha	93.50%	89.00%
CHEMBL2581	P07339	Cathepsin D	93.41%	98.95%
CHEMBL2635	P51452	Dual specificity protein phosphatase 3	90.16%	94.00%
CHEMBL3192	Q9BY41	Histone deacetylase 8	90.08%	93.99%
CHEMBL4478	Q00975	Voltage-gated N-type calcium channel alpha-1B subunit	89.43%	97.14%
CHEMBL255	P29275	Adenosine A2b receptor	89.38%	98.59%
CHEMBL2095172	P14867	GABA-A receptor; alpha-1/beta-2/gamma-2	87.93%	92.67%
CHEMBL3137262	O60341	LSD1/CoREST complex	87.30%	97.09%
CHEMBL1293249	Q13887	Kruppel-like factor 5	87.06%	86.33%
CHEMBL3038477	P67870	Casein kinase II alpha/beta	86.90%	99.23%
CHEMBL2095226	P05556	Integrin alpha-5/beta-1	85.40%	96.39%
CHEMBL222	P23975	Norepinephrine transporter	81.08%	96.06%
CHEMBL5103	Q969S8	Histone deacetylase 10	80.39%	90.08%
CHEMBL4208	P20618	Proteasome component C5	80.11%	90.00%

Plants that contains it

There are no matching plants.

Cross-Links

• PubChem: 49831000
• LOTUS: LTS0078033
• wikiData: Q104389671