Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Leu-Aib-Gly-Aib-Aib-Pro-Val-Aib-Aib-Gln-Gln-xiIle-ol

Details

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Internal ID c35f3323-8946-4e98-b054-23a773ec66ce
Taxonomy Organic Polymers > Polypeptides
IUPAC Name (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[(2S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidine-2-carbonyl]amino]-2-methylpropanoyl]amino]propanoyl]amino]-2-methylpropanoyl]amino]propanoyl]amino]-N-[1-[[(2S)-1-[[1-[[2-[[1-[[1-[(2S)-2-[[(2S)-1-[[1-[[1-[[(2S)-5-amino-1-[[(2S)-5-amino-1-[[(2S)-1-hydroxy-3-methylpentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-methyl-1-oxopropan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-methyl-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-methyl-1-oxopropan-2-yl]pentanediamide
SMILES (Canonical) CCC(C)C(CO)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C1CCCN1C(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)CNC(=O)C(C)(C)NC(=O)C(CC(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C2CCCN2C(=O)C(C)(C)NC(=O)C
SMILES (Isomeric) CCC(C)[C@@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)CNC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)C(C)(C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@@H]2CCCN2C(=O)C(C)(C)NC(=O)C
InChI InChI=1S/C88H151N23O24/c1-28-46(6)54(43-112)97-64(120)50(33-36-57(89)114)96-65(121)51(34-37-58(90)115)98-75(131)84(18,19)108-77(133)86(22,23)107-70(126)61(45(4)5)100-68(124)55-31-29-39-110(55)79(135)88(26,27)109-76(132)85(20,21)102-60(117)42-92-71(127)80(10,11)105-67(123)53(41-44(2)3)99-74(130)83(16,17)104-66(122)52(35-38-59(91)116)95-62(118)47(7)93-72(128)81(12,13)103-63(119)48(8)94-73(129)82(14,15)106-69(125)56-32-30-40-111(56)78(134)87(24,25)101-49(9)113/h44-48,50-56,61,112H,28-43H2,1-27H3,(H2,89,114)(H2,90,115)(H2,91,116)(H,92,127)(H,93,128)(H,94,129)(H,95,118)(H,96,121)(H,97,120)(H,98,131)(H,99,130)(H,100,124)(H,101,113)(H,102,117)(H,103,119)(H,104,122)(H,105,123)(H,106,125)(H,107,126)(H,108,133)(H,109,132)/t46?,47-,48-,50-,51-,52-,53-,54+,55-,56-,61-/m0/s1
InChI Key OHIBKPQBJOSRSQ-FENMDWRWSA-N
Popularity 0 references in papers

Physical and Chemical Properties

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Molecular Formula C88H151N23O24
Molecular Weight 1915.30 g/mol
Exact Mass 1914.13023278 g/mol
Topological Polar Surface Area (TPSA) 714.00 Ų
XlogP -3.50

Synonyms

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There are no found synonyms.

2D Structure

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2D Structure of Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Leu-Aib-Gly-Aib-Aib-Pro-Val-Aib-Aib-Gln-Gln-xiIle-ol

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 99.81% 98.95%
CHEMBL3837 P07711 Cathepsin L 99.64% 96.61%
CHEMBL220 P22303 Acetylcholinesterase 99.39% 94.45%
CHEMBL4018 P49146 Neuropeptide Y receptor type 2 99.01% 98.94%
CHEMBL1795139 Q8IU80 Transmembrane protease serine 6 98.57% 98.33%
CHEMBL3359 P21462 Formyl peptide receptor 1 98.11% 93.56%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 97.86% 96.09%
CHEMBL2730 P21980 Protein-glutamine gamma-glutamyltransferase 97.43% 92.38%
CHEMBL4979 P13866 Sodium/glucose cotransporter 1 97.33% 98.24%
CHEMBL4588 P22894 Matrix metalloproteinase 8 97.29% 94.66%
CHEMBL1914 P06276 Butyrylcholinesterase 96.91% 95.00%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 96.38% 96.47%
CHEMBL3137262 O60341 LSD1/CoREST complex 96.35% 97.09%
CHEMBL1907591 P30926 Neuronal acetylcholine receptor; alpha4/beta4 96.13% 100.00%
CHEMBL2514 O95665 Neurotensin receptor 2 96.06% 100.00%
CHEMBL333 P08253 Matrix metalloproteinase-2 95.94% 96.31%
CHEMBL206 P03372 Estrogen receptor alpha 95.92% 97.64%
CHEMBL4625 Q07817 Apoptosis regulator Bcl-X 95.88% 99.77%
CHEMBL259 P32245 Melanocortin receptor 4 95.80% 95.38%
CHEMBL2094135 Q96BI3 Gamma-secretase 95.68% 98.05%
CHEMBL321 P14780 Matrix metalloproteinase 9 95.25% 92.12%
CHEMBL4777 P25929 Neuropeptide Y receptor type 1 95.16% 96.67%
CHEMBL2815 P04629 Nerve growth factor receptor Trk-A 95.09% 87.16%
CHEMBL340 P08684 Cytochrome P450 3A4 94.70% 91.19%
CHEMBL236 P41143 Delta opioid receptor 94.66% 99.35%
CHEMBL4801 P29466 Caspase-1 94.49% 96.85%
CHEMBL4227 P25090 Lipoxin A4 receptor 94.45% 100.00%
CHEMBL230 P35354 Cyclooxygenase-2 94.43% 89.63%
CHEMBL237 P41145 Kappa opioid receptor 94.36% 98.10%
CHEMBL283 P08254 Matrix metalloproteinase 3 93.74% 97.29%
CHEMBL2073 P07947 Tyrosine-protein kinase YES 93.70% 83.14%
CHEMBL3267 P48736 PI3-kinase p110-gamma subunit 93.44% 95.71%
CHEMBL335 P18031 Protein-tyrosine phosphatase 1B 93.25% 95.17%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 93.11% 97.14%
CHEMBL4026 P40763 Signal transducer and activator of transcription 3 92.94% 82.69%
CHEMBL2955 O95136 Sphingosine 1-phosphate receptor Edg-5 92.24% 92.86%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 92.23% 97.64%
CHEMBL3176 O43603 Galanin receptor 2 91.90% 98.89%
CHEMBL253 P34972 Cannabinoid CB2 receptor 91.77% 97.25%
CHEMBL1873 P00750 Tissue-type plasminogen activator 91.61% 93.33%
CHEMBL4394 Q9NYA1 Sphingosine kinase 1 91.35% 96.03%
CHEMBL4123 P30989 Neurotensin receptor 1 91.29% 96.67%
CHEMBL2492 P36544 Neuronal acetylcholine receptor protein alpha-7 subunit 91.11% 88.42%
CHEMBL3892 Q99500 Sphingosine 1-phosphate receptor Edg-3 91.11% 97.29%
CHEMBL3830 Q2M2I8 Adaptor-associated kinase 90.82% 83.10%
CHEMBL1944495 P28065 Proteasome subunit beta type-9 90.74% 97.50%
CHEMBL3437 Q16853 Amine oxidase, copper containing 90.05% 94.00%
CHEMBL3024 P53350 Serine/threonine-protein kinase PLK1 89.93% 97.43%
CHEMBL4816 Q9Y243 Serine/threonine-protein kinase AKT3 89.18% 96.28%
CHEMBL1907594 P30926 Neuronal acetylcholine receptor; alpha3/beta4 89.13% 97.23%
CHEMBL3430907 Q96GD4 Aurora kinase B/Inner centromere protein 88.34% 97.50%
CHEMBL2274 Q9H228 Sphingosine 1-phosphate receptor Edg-8 87.97% 100.00%
CHEMBL2534 O15530 3-phosphoinositide dependent protein kinase-1 87.93% 95.36%
CHEMBL3060 Q9Y345 Glycine transporter 2 87.70% 99.17%
CHEMBL2140 P48775 Tryptophan 2,3-dioxygenase 87.52% 98.46%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 87.50% 94.45%
CHEMBL4005 P42336 PI3-kinase p110-alpha subunit 87.39% 97.47%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 87.33% 91.11%
CHEMBL3238 P23786 Carnitine palmitoyltransferase 2 87.08% 94.05%
CHEMBL2111367 P27986 PI3-kinase p110-alpha/p85-alpha 86.96% 94.33%
CHEMBL1075317 P61964 WD repeat-containing protein 5 86.89% 96.33%
CHEMBL3105 P09874 Poly [ADP-ribose] polymerase-1 86.81% 93.90%
CHEMBL3018 Q9Y5Y6 Matriptase 86.59% 98.33%
CHEMBL1075094 Q16236 Nuclear factor erythroid 2-related factor 2 86.46% 96.00%
CHEMBL4660 P28907 Lymphocyte differentiation antigen CD38 85.93% 95.27%
CHEMBL5261 Q7L7X3 Serine/threonine-protein kinase TAO1 85.93% 89.33%
CHEMBL1744525 P43490 Nicotinamide phosphoribosyltransferase 85.85% 96.25%
CHEMBL221 P23219 Cyclooxygenase-1 85.44% 90.17%
CHEMBL5701 Q9H2K8 Serine/threonine-protein kinase TAO3 85.26% 96.67%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 85.09% 93.00%
CHEMBL2781 P19634 Sodium/hydrogen exchanger 1 85.00% 90.24%
CHEMBL3145 P42338 PI3-kinase p110-beta subunit 84.50% 98.75%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 84.37% 90.71%
CHEMBL2007625 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic 84.35% 99.00%
CHEMBL4685 P14902 Indoleamine 2,3-dioxygenase 84.26% 96.38%
CHEMBL344 Q99705 Melanin-concentrating hormone receptor 1 83.86% 92.50%
CHEMBL5600 P27448 Serine/threonine-protein kinase c-TAK1 83.55% 88.81%
CHEMBL5163 Q9NY46 Sodium channel protein type III alpha subunit 83.55% 96.90%
CHEMBL274 P51681 C-C chemokine receptor type 5 83.47% 98.77%
CHEMBL4246 P42680 Tyrosine-protein kinase TEC 83.43% 82.05%
CHEMBL3776 Q14790 Caspase-8 83.28% 97.06%
CHEMBL4793 Q86TI2 Dipeptidyl peptidase IX 82.77% 96.95%
CHEMBL5028 O14672 ADAM10 82.58% 97.50%
CHEMBL4361 Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 82.53% 95.52%
CHEMBL3474 P14555 Phospholipase A2 group IIA 81.65% 94.05%
CHEMBL2474 P53582 Methionine aminopeptidase 1 81.62% 97.09%
CHEMBL3392948 Q9NP59 Solute carrier family 40 member 1 81.49% 95.00%
CHEMBL4657 Q6V1X1 Dipeptidyl peptidase VIII 81.44% 97.21%
CHEMBL2069156 Q14145 Kelch-like ECH-associated protein 1 81.15% 82.38%
CHEMBL2095164 P49354 Geranylgeranyl transferase type I 80.46% 92.80%
CHEMBL225 P28335 Serotonin 2c (5-HT2c) receptor 80.17% 89.62%
CHEMBL3691 Q13822 Autotaxin 80.15% 96.39%
CHEMBL5103 Q969S8 Histone deacetylase 10 80.06% 90.08%
CHEMBL3351 Q13085 Acetyl-CoA carboxylase 1 80.00% 93.04%

Plants that contains it

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Cross-Links

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PubChem 101639443
LOTUS LTS0185815
wikiData Q105192093