8-Hydroxy-2'-Deoxyguanosine

Details

• Internal ID: 8ca31e34-8293-4234-acfd-167e5366a788
• Taxonomy: Nucleosides, nucleotides, and analogues > Purine nucleosides > Purine 2-deoxyribonucleosides
• IUPAC Name: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,7-dihydropurine-6,8-dione
• InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
• InChI Key: HCAJQHYUCKICQH-VPENINKCSA-N
• Popularity: 7,363 references in papers

Physical and Chemical Properties

• Molecular Formula: C₁₀H₁₃N₅O₅
• Molecular Weight: 283.24 g/mol
• Exact Mass: 283.09166853 g/mol
• Topological Polar Surface Area (TPSA): 150.00 Ų
• XlogP: -2.60

Synonyms

• 8-Hydroxy-2'-deoxyguanosine
• 8-Oxo-2'-deoxyguanosine
• 8-Oxo-dG
• 8-Hydroxydeoxyguanosine
• 8-Oxo-7,8-dihydro-2'-deoxyguanosine
• 8-OHdG
• 8-Oxo-7-hydrodeoxyguanosine
• 8-Oxo-2'-deoxyguanine
• 2'-deoxy-8-oxoguanosine
• Guanosine, 2'-deoxy-7,8-dihydro-8-oxo-
• 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione
• 7,8-Dihydro-2'-deoxy-8-oxoguanosine
• 8-hydroxy-deoxyguanosine
• 8-Oxodeoxyguanosine
• CHEBI:40304
• 8-oxo-2'-dG
• 8-hydroxy-2-deoxyguanosine
• 4RGB38T3IB
• 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
• CID 5287560
• 8HG
• 8-oxodG
• 8-oxo-7,8-dihydrodeoxyguanosine
• 7,8-dihydro-8-oxo-2'-deoxyguanosine
• 2'-deoxy-8-hydroxyguanosine
• CCRIS 8239
• 7,8-Dihydro-8-oxodeoxyguanosine
• oh8dG
• 8 Oxo dG
• 8-Hydroxydesoxyguanosin
• 2a5b
• 8-hydroxydeoxy-guanosine
• 8 OHdG
• Guanosine, 7,8-dihydro-2'-deoxy-8-oxo-
• Epitope ID:151526
• UNII-4RGB38T3IB
• 8-hydroxy-2'deoxyguanosine
• Discontinued See O850250
• SCHEMBL114652
• CHEMBL1230628
• DTXSID60904338
• HMS3649O10
• AKOS024262435
• CS-W012256
• DB02502
• HY-W011540
• AC-32342
• AS-74648
• A12921
• A848840
• Q270154
• SR-01000946628
• SR-01000946628-1
• 2-Amino-9-(2-deoxyribofuranosyl)-3,7-dihydropurine-6,8-dione
• 2-amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
• 2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
• 2-amino-8-hydroxy-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one
• 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,7-dihydropurine-6,8-dione
• 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7,8,9-tetrahydro-3H-purine-6,8-dione
• 8-Hydroxydeoxyguanosine?2-amino-8-hydroxy-9-((2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
• 8-Hydroxydeoxyguanosine2-amino-8-hydroxy-9-((2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one

2D Structure

ADMET Properties (via admetSAR 2)

Target	Value	Probability (raw)	Probability (%)
No predicted properties yet!

Targets

Proven Targets:

No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID	UniProt ID	Name	Probability	Model accuracy
CHEMBL4040	P28482	MAP kinase ERK2	98.81%	83.82%
CHEMBL3251	P19838	Nuclear factor NF-kappa-B p105 subunit	96.80%	96.09%
CHEMBL3137262	O60341	LSD1/CoREST complex	95.93%	97.09%
CHEMBL4016	P42262	Glutamate receptor ionotropic, AMPA 2	93.47%	86.92%
CHEMBL4261	Q16665	Hypoxia-inducible factor 1 alpha	92.03%	85.14%
CHEMBL4203	Q9HAZ1	Dual specificity protein kinase CLK4	90.76%	94.45%
CHEMBL3038477	P67870	Casein kinase II alpha/beta	89.81%	99.23%
CHEMBL2635	P51452	Dual specificity protein phosphatase 3	87.62%	94.00%
CHEMBL3384	Q16512	Protein kinase N1	84.73%	80.71%
CHEMBL1929	P47989	Xanthine dehydrogenase	83.19%	96.12%
CHEMBL3880	P07900	Heat shock protein HSP 90-alpha	82.40%	96.21%
CHEMBL2107	P61073	C-X-C chemokine receptor type 4	82.10%	93.10%
CHEMBL3108638	O15164	Transcription intermediary factor 1-alpha	81.75%	95.56%
CHEMBL2140	P48775	Tryptophan 2,3-dioxygenase	81.63%	98.46%
CHEMBL1978	P11511	Cytochrome P450 19A1	80.84%	91.76%
CHEMBL1937	Q92769	Histone deacetylase 2	80.70%	94.75%

Plants that contains it

There are no matching plants.

Cross-Links

• PubChem: 135440064
• LOTUS: LTS0075484
• wikiData: Q270154