deamino-Val(2,3-dehydro)-DL-Val-DL-Tyr-DL-xiThr(1)-DL-Ala-Abu(2,3-dehydro)-DL-Glu-DL-Nle(Ph(4-OH))-(1)

Details

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Internal ID 41b937e1-19e9-4744-8c7e-a1f4f57e4c76
Taxonomy Organic acids and derivatives > Peptidomimetics > Depsipeptides > Cyclic depsipeptides
IUPAC Name 3-[9-ethylidene-3-[4-(4-hydroxyphenyl)butyl]-15-[[3-(4-hydroxyphenyl)-2-[[3-methyl-2-(3-methylbut-2-enoylamino)butanoyl]amino]propanoyl]amino]-12,16-dimethyl-2,5,8,11,14-pentaoxo-1-oxa-4,7,10,13-tetrazacyclohexadec-6-yl]propanoic acid
SMILES (Canonical) CC=C1C(=O)NC(C(=O)NC(C(=O)OC(C(C(=O)NC(C(=O)N1)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(C(C)C)NC(=O)C=C(C)C)C)CCCCC3=CC=C(C=C3)O)CCC(=O)O
SMILES (Isomeric) CC=C1C(=O)NC(C(=O)NC(C(=O)OC(C(C(=O)NC(C(=O)N1)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(C(C)C)NC(=O)C=C(C)C)C)CCCCC3=CC=C(C=C3)O)CCC(=O)O
InChI InChI=1S/C47H63N7O13/c1-8-33-42(61)50-34(21-22-38(58)59)43(62)51-35(12-10-9-11-29-13-17-31(55)18-14-29)47(66)67-28(7)40(46(65)48-27(6)41(60)49-33)54-44(63)36(24-30-15-19-32(56)20-16-30)52-45(64)39(26(4)5)53-37(57)23-25(2)3/h8,13-20,23,26-28,34-36,39-40,55-56H,9-12,21-22,24H2,1-7H3,(H,48,65)(H,49,60)(H,50,61)(H,51,62)(H,52,64)(H,53,57)(H,54,63)(H,58,59)
InChI Key ROTNPXNPAMNTOL-UHFFFAOYSA-N
Popularity 0 references in papers

Physical and Chemical Properties

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Molecular Formula C47H63N7O13
Molecular Weight 934.00 g/mol
Exact Mass 933.44838509 g/mol
Topological Polar Surface Area (TPSA) 308.00 Ų
XlogP 4.30

Synonyms

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There are no found synonyms.

2D Structure

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2D Structure of deamino-Val(2,3-dehydro)-DL-Val-DL-Tyr-DL-xiThr(1)-DL-Ala-Abu(2,3-dehydro)-DL-Glu-DL-Nle(Ph(4-OH))-(1)

3D Structure

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ADMET Properties (via admetSAR 2)

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Target Value Probability (raw) Probability (%)
No predicted properties yet!

Targets

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Proven Targets:

CHEMBL ID UniProt ID Name Min activity Assay type Source
No proven targets yet!

Predicted Targets (via Super-PRED):

CHEMBL ID UniProt ID Name Probability Model accuracy
CHEMBL2581 P07339 Cathepsin D 99.70% 98.95%
CHEMBL5619 P27695 DNA-(apurinic or apyrimidinic site) lyase 98.19% 91.11%
CHEMBL4203 Q9HAZ1 Dual specificity protein kinase CLK4 97.58% 94.45%
CHEMBL236 P41143 Delta opioid receptor 97.47% 99.35%
CHEMBL3837 P07711 Cathepsin L 96.93% 96.61%
CHEMBL3251 P19838 Nuclear factor NF-kappa-B p105 subunit 95.86% 96.09%
CHEMBL3060 Q9Y345 Glycine transporter 2 95.15% 99.17%
CHEMBL1255126 O15151 Protein Mdm4 94.80% 90.20%
CHEMBL2514 O95665 Neurotensin receptor 2 92.82% 100.00%
CHEMBL5163 Q9NY46 Sodium channel protein type III alpha subunit 90.20% 96.90%
CHEMBL5103 Q969S8 Histone deacetylase 10 90.19% 90.08%
CHEMBL2553 Q15418 Ribosomal protein S6 kinase alpha 1 89.33% 85.11%
CHEMBL2107 P61073 C-X-C chemokine receptor type 4 89.01% 93.10%
CHEMBL4040 P28482 MAP kinase ERK2 88.75% 83.82%
CHEMBL3359 P21462 Formyl peptide receptor 1 88.70% 93.56%
CHEMBL3108638 O15164 Transcription intermediary factor 1-alpha 88.37% 95.56%
CHEMBL5939 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 88.26% 100.00%
CHEMBL5845 P23415 Glycine receptor subunit alpha-1 88.26% 90.71%
CHEMBL2693 Q9UIQ6 Cystinyl aminopeptidase 88.23% 97.64%
CHEMBL1907603 Q05586 Glutamate NMDA receptor; GRIN1/GRIN2B 87.98% 95.89%
CHEMBL4261 Q16665 Hypoxia-inducible factor 1 alpha 87.83% 85.14%
CHEMBL340 P08684 Cytochrome P450 3A4 87.63% 91.19%
CHEMBL4478 Q00975 Voltage-gated N-type calcium channel alpha-1B subunit 87.53% 97.14%
CHEMBL1806 P11388 DNA topoisomerase II alpha 87.42% 89.00%
CHEMBL4072 P07858 Cathepsin B 84.50% 93.67%
CHEMBL259 P32245 Melanocortin receptor 4 83.62% 95.38%
CHEMBL3468 P55210 Caspase-7 83.37% 95.68%
CHEMBL2274 Q9H228 Sphingosine 1-phosphate receptor Edg-8 83.08% 100.00%
CHEMBL3891 P07384 Calpain 1 82.30% 93.04%
CHEMBL2072 P35499 Sodium channel protein type IV alpha subunit 82.23% 92.32%
CHEMBL1944 P08473 Neprilysin 82.17% 92.63%
CHEMBL1937 Q92769 Histone deacetylase 2 81.83% 94.75%
CHEMBL4227 P25090 Lipoxin A4 receptor 81.61% 100.00%
CHEMBL3091268 Q92753 Nuclear receptor ROR-beta 81.57% 95.50%
CHEMBL3392948 Q9NP59 Solute carrier family 40 member 1 80.99% 95.00%
CHEMBL3130 O00329 PI3-kinase p110-delta subunit 80.66% 96.47%
CHEMBL3976 Q9UHL4 Dipeptidyl peptidase II 80.57% 92.29%
CHEMBL3807 P17706 T-cell protein-tyrosine phosphatase 80.55% 93.00%

Plants that contains it

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Below are displayed all the plants proven (via scientific papers) to contain this compound!
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Cross-Links

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PubChem 73237112
LOTUS LTS0132139
wikiData Q104196819